Article ; Online: Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States.
2020 Volume 26, Issue 9, Page(s) 2005–2015
Abstract: ... with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Characterization of the histopathology and cellular localization ... as the predominant pulmonary pathology. SARS-CoV-2 was detectable by immunohistochemistry and electron microscopy ... immunohistochemical, and electron microscopic findings in tissues from 8 fatal laboratory-confirmed cases of SARS-CoV ...
| Abstract | An ongoing pandemic of coronavirus disease (COVID-19) is caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Characterization of the histopathology and cellular localization of SARS-CoV-2 in the tissues of patients with fatal COVID-19 is critical to further understand its pathogenesis and transmission and for public health prevention measures. We report clinicopathologic, immunohistochemical, and electron microscopic findings in tissues from 8 fatal laboratory-confirmed cases of SARS-CoV-2 infection in the United States. All cases except 1 were in residents of long-term care facilities. In these patients, SARS-CoV-2 infected epithelium of the upper and lower airways with diffuse alveolar damage as the predominant pulmonary pathology. SARS-CoV-2 was detectable by immunohistochemistry and electron microscopy in conducting airways, pneumocytes, alveolar macrophages, and a hilar lymph node but was not identified in other extrapulmonary tissues. Respiratory viral co-infections were identified in 3 cases; 3 cases had evidence of bacterial co-infection. |
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| MeSH term(s) | Aged ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Female ; Humans ; Immunohistochemistry ; Lung/pathology ; Lung/virology ; Male ; Microscopy, Electron ; Middle Aged ; Pandemics ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; SARS-CoV-2 ; United States/epidemiology |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-05-21 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 1380686-5 |
| ISSN | 1080-6059 ; 1080-6040 |
| ISSN (online) | 1080-6059 |
| ISSN | 1080-6040 |
| DOI | 10.3201/eid2609.202095 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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