Article ; Online: Low HDL and high triglycerides predict COVID-19 severity.
2021 Volume 11, Issue 1, Page(s) 7217
Abstract: ... the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL ... to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had ... and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated ...
| Abstract | Lipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19. |
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| MeSH term(s) | Aged ; COVID-19/blood ; COVID-19/etiology ; Cholesterol, HDL/blood ; Female ; Ferritins/blood ; Fibrin Fibrinogen Degradation Products/analysis ; Hospitalization ; Humans ; Lipids/blood ; Male ; Middle Aged ; Severity of Illness Index ; Triglycerides/blood |
| Chemical Substances | Cholesterol, HDL ; Fibrin Fibrinogen Degradation Products ; Lipids ; Triglycerides ; fibrin fragment D ; Ferritins (9007-73-2) |
| Language | English |
| Publishing date | 2021-03-30 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-021-86747-5 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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