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Article: Capillary leak syndrome induced by neoadjuvant cisplatin and gemcitabine in a patient with bladder cancer.

Massafra, Marco / Passalacqua, Maria Ilenia / Lupo, Giuseppe / Altavilla, Giuseppe / Santarpia, Mariacarmela

Urology case reports

2020  Volume 34, Page(s) 101461

Abstract: ... treatment with Cisplatin and Gemcitabine. Treatment with infusion of albumin and increasing corticosteroid doses and ... Capillary leak syndrome (CLS) is a rare disorder associated with an increased capillar ... in a 54-year-old man affected by muscle-invasive bladder cancer who received neoadjuvant ...

Abstract Capillary leak syndrome (CLS) is a rare disorder associated with an increased capillar permeability due to an endothelial damage, causing leakage of plasma and proteins into the interstitial compartment. CLS is characterized by rapidly developing edema, hypotension and hypoproteinemia. We observed CLS in a 54-year-old man affected by muscle-invasive bladder cancer who received neoadjuvant treatment with Cisplatin and Gemcitabine. Treatment with infusion of albumin and increasing corticosteroid doses and diuretics led to a complete regression of all signs and symptoms related to the disorder. Of note, the patient showed an objective complete response to chemotherapy and underwent radical surgery on schedule.
Keywords covid19
Language English
Publishing date 2020-10-21
Publishing country United States
Document type Case Reports
ZDB-ID 2745459-9
ISSN 2214-4420
ISSN 2214-4420
DOI 10.1016/j.eucr.2020.101461
Database MEDical Literature Analysis and Retrieval System OnLINE

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