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  1. Article: Lions, tigers and kittens too: ACE2 and susceptibility to COVID-19.

    Mathavarajah, Sabateeshan / Dellaire, Graham

    Evolution, medicine, and public health

    2020  Volume 2020, Issue 1, Page(s) 109–113

    Abstract: ... receptor angiotensin converting enzyme 2 (ACE2), we characterized the structure and evolution of ACE2 ... in several of these species and identify a single interacting amino acid residue conserved between human and ... SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) has been reported to infect ...

    Abstract SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) has been reported to infect domesticated animals in a species-specific manner, where cats were susceptible but not dogs. Using the recently published crystal structure of the SARS-CoV-2 spike protein complexed with the human host cell receptor angiotensin converting enzyme 2 (ACE2), we characterized the structure and evolution of ACE2 in several of these species and identify a single interacting amino acid residue conserved between human and
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2684837-5
    ISSN 2050-6201
    ISSN 2050-6201
    DOI 10.1093/emph/eoaa021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Lions, Tigers and Kittens too: ACE2 and susceptibility to CoVID-19

    Mathavarajah, Sabateeshan / Dellaire, Graham

    Evolution, Medicine, and Public Health

    Abstract: ... we characterized the structure and evolution of ACE2 in several of these species and identify a single interacting ... amino acid residue conserved between human and Felidae ACE2 but not in Canidae that correlates with virus ... susceptibility Using computational analyses we describe how this site likely affects ACE2 targeting by the virus ...

    Abstract SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) has been reported to infect domesticated animals in a species-specific manner, where cats were susceptible but not dogs Using the recently published crystal structure of the SARS-CoV-2 spike protein complexed with the human host cell receptor ACE2, we characterized the structure and evolution of ACE2 in several of these species and identify a single interacting amino acid residue conserved between human and Felidae ACE2 but not in Canidae that correlates with virus susceptibility Using computational analyses we describe how this site likely affects ACE2 targeting by the virus Thus, we highlight how evolution-based approaches can be used to form hypotheses and study animal transmission of such viruses in the future
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #631178
    Database COVID19

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  3. Article ; Online: Lions, tigers and kittens too

    Mathavarajah, Sabateeshan / Dellaire, Graham

    Evolution, Medicine, and Public Health

    ACE2 and susceptibility to COVID-19

    2020  Volume 2020, Issue 1, Page(s) 109–113

    Abstract: ... receptor angiotensin converting enzyme 2 (ACE2), we characterized the structure and evolution of ACE2 ... in several of these species and identify a single interacting amino acid residue conserved between human and Felidae ACE2 ... but not in Canidae that correlates with virus susceptibility. Using computational analyses we describe how ...

    Abstract Abstract SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) has been reported to infect domesticated animals in a species-specific manner, where cats were susceptible but not dogs. Using the recently published crystal structure of the SARS-CoV-2 spike protein complexed with the human host cell receptor angiotensin converting enzyme 2 (ACE2), we characterized the structure and evolution of ACE2 in several of these species and identify a single interacting amino acid residue conserved between human and Felidae ACE2 but not in Canidae that correlates with virus susceptibility. Using computational analyses we describe how this site likely affects ACE2 targeting by the virus. Thus, we highlight how evolution-based approaches can be used to form hypotheses and study animal transmission of such viruses in the future.
    Keywords covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2684837-5
    ISSN 2050-6201
    ISSN 2050-6201
    DOI 10.1093/emph/eoaa021
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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