LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 3 of total 3

Search options

  1. Article: Viewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular Flexibility.

    Matsuo, Tatsuhito

    Biology

    2021  Volume 10, Issue 6

    Abstract: The latest coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19) pneumonia ... leading to the pandemic, contains 29 proteins. Among them, nucleocapsid protein (N ...

    Abstract The latest coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19) pneumonia leading to the pandemic, contains 29 proteins. Among them, nucleocapsid protein (N
    Language English
    Publishing date 2021-05-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10060454
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Viewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular Flexibility

    Tatsuhito Matsuo

    Biology, Vol 10, Iss 454, p

    2021  Volume 454

    Abstract: The latest coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19) pneumonia ... leading to the pandemic, contains 29 proteins. Among them, nucleocapsid protein (N CoV2 ) is one ... of the research of N CoV2 is described in terms of molecular structure and dynamics. N CoV2 consists of two ...

    Abstract The latest coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19) pneumonia leading to the pandemic, contains 29 proteins. Among them, nucleocapsid protein (N CoV2 ) is one of the abundant proteins and shows multiple functions including packaging the RNA genome during the infection cycle. It has also emerged as a potential drug target. In this review, the current status of the research of N CoV2 is described in terms of molecular structure and dynamics. N CoV2 consists of two domains, i.e., the N-terminal domain (NTD) and the C-terminal domain (CTD) with a disordered region between them. Recent simulation studies have identified several potential drugs that can bind to NTD or CTD with high affinity. Moreover, it was shown that the degree of flexibility in the disordered region has a large effect on drug binding rate, suggesting the importance of molecular flexibility for the N CoV2 function. Molecular flexibility has also been shown to be integral to the formation of droplets, where N CoV2 , RNA and/or other viral proteins gather through liquid-liquid phase separation and considered important for viral replication. Finally, as one of the future research directions, a strategy for obtaining the structural and dynamical information on the proteins contained in droplets is presented.
    Keywords coronavirus nucleocapsid protein ; molecular flexibility ; protein structure ; protein dynamics ; liquid-liquid phase separation ; neutron scattering ; Biology (General) ; QH301-705.5
    Subject code 572
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article: Viewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular Flexibility

    Matsuo, Tatsuhito

    Biology. 2021 May 21, v. 10, no. 6

    2021  

    Abstract: The latest coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19) pneumonia ... leading to the pandemic, contains 29 proteins. Among them, nucleocapsid protein (NCᵒⱽ²) is one ... of the research of NCᵒⱽ² is described in terms of molecular structure and dynamics. NCᵒⱽ² consists of two domains ...

    Abstract The latest coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19) pneumonia leading to the pandemic, contains 29 proteins. Among them, nucleocapsid protein (NCᵒⱽ²) is one of the abundant proteins and shows multiple functions including packaging the RNA genome during the infection cycle. It has also emerged as a potential drug target. In this review, the current status of the research of NCᵒⱽ² is described in terms of molecular structure and dynamics. NCᵒⱽ² consists of two domains, i.e., the N-terminal domain (NTD) and the C-terminal domain (CTD) with a disordered region between them. Recent simulation studies have identified several potential drugs that can bind to NTD or CTD with high affinity. Moreover, it was shown that the degree of flexibility in the disordered region has a large effect on drug binding rate, suggesting the importance of molecular flexibility for the NCᵒⱽ² function. Molecular flexibility has also been shown to be integral to the formation of droplets, where NCᵒⱽ², RNA and/or other viral proteins gather through liquid-liquid phase separation and considered important for viral replication. Finally, as one of the future research directions, a strategy for obtaining the structural and dynamical information on the proteins contained in droplets is presented.
    Keywords COVID-19 infection ; RNA ; Severe acute respiratory syndrome coronavirus 2 ; amino acid sequences ; drugs ; genome ; nucleocapsid proteins ; pandemic ; pneumonia ; separation ; virus replication
    Language English
    Dates of publication 2021-0521
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology10060454
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top