Article ; Online: Differences in Cardiac Magnetic Resonance Imaging Markers Between Patients With COVID-19-associated Myocardial Injury and Patients With Clinically Suspected Myocarditis.
2021 Volume 36, Issue 5, Page(s) 279–285
Abstract: ... magnetic resonance imaging (CMRI) between COVID-19 and all-cause myocarditis.: Materials and methods: We examined CMRI ... of patients with COVID-19 and elevated high-sensitivity serum troponin levels performed between March 31st and ... May 5th and compared them to CMRI of patients without SARS-CoV-2 infection with suspected myocarditis ...
| Abstract | Purpose: Coronavirus 2019 disease (COVID-19) has been shown to affect the myocardium, resulting in a worse clinical outcome. In this registry study, we aimed to identify differences in cardiac magnetic resonance imaging (CMRI) between COVID-19 and all-cause myocarditis. Materials and methods: We examined CMRI of patients with COVID-19 and elevated high-sensitivity serum troponin levels performed between March 31st and May 5th and compared them to CMRI of patients without SARS-CoV-2 infection with suspected myocarditis in the same time period. For this purpose, we evaluated Lake-Louise Criteria for myocarditis by determining nonischemic myocardial injury via T1-mapping, extracellular volume, late gadolinium enhancement, and myocardial edema (ME) by T2-mapping and fat-saturated T2w imaging (T2Q). Results: A total of 15 of 18 (89%) patients with COVID-19 had abnormal findings. The control group consisted of 18 individuals. There were significantly fewer individuals with COVID-19 who had increased T2 (5 vs. 10; P=0.038) and all-cause ME (7 vs. 15; P=0.015); thus, significantly fewer patients with COVID-19 fulfilled Lake-Louise Criteria (6 vs. 17; P<0.001). In contrast, nonischemic myocardial injury was not significantly different. In the COVID-19 group, indexed end-diastolic volume of the left ventricle showed a significant correlation to the extent of abnormal T1 (R2=0.571; P=0.017) and extracellular volume (R2=0.605; P=0.013) and absolute T1, T2, and T2Q (R2=0.644; P=0.005, R2=0.513; P=0.035 and R2=0.629; P=0.038, respectively); in the control group, only extracellular volume showed a weak correlation (R2=0.490; P=0.046). Conclusions: Cardiac involvement in COVID-19 seems to show less ME than all-cause myocarditis. Abnormal CMRI markers correlated to left ventricle dilation only in the COVID-19 group. Larger comparative studies are needed to verify our findings. |
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| MeSH term(s) | COVID-19/diagnostic imaging ; Contrast Media ; Diagnosis, Differential ; Gadolinium ; Humans ; Magnetic Resonance Imaging, Cine ; Myocarditis/diagnostic imaging ; Myocardium ; Predictive Value of Tests | |||||
| Chemical Substances | Contrast Media ; Gadolinium (AU0V1LM3JT) | |||||
| Language | English | |||||
| Publishing date | 2021-04-21 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 632900-7 | |||||
| ISSN | 1536-0237 ; 0883-5993 | |||||
| ISSN (online) | 1536-0237 | |||||
| ISSN | 0883-5993 | |||||
| DOI | 10.1097/RTI.0000000000000599 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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