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  1. Article ; Online: Sarcoidosis of the pancreas mimicking adenocarcinoma.

    Mayne, Alistair Ivan William / Ahmad, Jawad / Loughrey, Maurice / Taylor, Mark A

    BMJ case reports

    2013  Volume 2013

    Abstract: ... Owing to the devastating nature of pancreatic adenocarcinoma, any mass in the pancreas must be ... to that of pancreatic adenocarcinoma. Preoperative diagnosis of primary pancreatic sarcoidosis is always challenging ... Primary sarcoidosis of the pancreas is extremely rare. Clinical presentation is often identical ...

    Abstract Primary sarcoidosis of the pancreas is extremely rare. Clinical presentation is often identical to that of pancreatic adenocarcinoma. Preoperative diagnosis of primary pancreatic sarcoidosis is always challenging. We present a 52-year-old man who developed weight loss and obstructive jaundice. Abdomino-pelvic CT scan showed a mass in the pancreatic head. After hepatopancreaticobiliary MDT discussion, a Whipple's procedure was attempted but the mass was deemed unresectable due to invasion of the superior mesenteric vein. Upon completion of palliative chemotherapy, repeat imaging showed significant mass shrinkage. A reattempt Whipple's procedure was successfully undertaken. Histology showed changes of chronic pancreatitis and peripancreatic granulomatous inflammation with no evidence of malignancy and a diagnosis of sarcoidosis was made. Owing to the devastating nature of pancreatic adenocarcinoma, any mass in the pancreas must be thoroughly investigated before a definitive diagnosis is made.
    MeSH term(s) Adenocarcinoma/diagnosis ; Adenocarcinoma/diagnostic imaging ; Adenocarcinoma/physiopathology ; Adult ; Aged ; Combined Modality Therapy ; Diagnosis, Differential ; Female ; Humans ; Male ; Middle Aged ; Pancreatic Diseases/diagnosis ; Pancreatic Diseases/diagnostic imaging ; Pancreatic Diseases/physiopathology ; Pancreatic Diseases/therapy ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/diagnostic imaging ; Pancreatic Neoplasms/physiopathology ; Sarcoidosis/diagnosis ; Sarcoidosis/diagnostic imaging ; Sarcoidosis/physiopathology ; Sarcoidosis/therapy ; Tomography, X-Ray Computed
    Language English
    Publishing date 2013-06-19
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2013-009118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Pancreatic sarcoidosis mimicking neoplasia: Case report.

    Chedid, Georges / Harb, Jad Gerges / Noureldine, Hussein A / Tayar, Claude / Nasser, Selim M / Sabbah, Nada Abbas

    International journal of surgery case reports

    2020  Volume 74, Page(s) 63–65

    Abstract: ... pancreatic cancer. We herein report a case of pancreatic sarcoidosis giving rise to a cancer-mimicking retention ... Introduction: Although sarcoidosis rarely involves the pancreas, such involvement may mimic ... granulomas consistent with sarcoidosis. In addition, a neuroendocrine adenoma, and an adjacent focus ...

    Abstract Introduction: Although sarcoidosis rarely involves the pancreas, such involvement may mimic pancreatic cancer. We herein report a case of pancreatic sarcoidosis giving rise to a cancer-mimicking retention cyst, concomitant with a neuroendocrine adenoma.
    Presentation of case: A 47-year-old Caucasian male presented to follow-up for a benign-appearing cyst of the tail of the pancreas, detected incidentally on CT scan done for a urinary stone in 2017. He had been asymptomatic since his last presentation. The lesion was found to have increased in size from 1 cm to 3 cm in greater diameter. Yet, a CT angiography showed no evidence of invasion of surrounding organs, vessels, or lymph nodes. The patient had previous medical history of treated sarcoidosis, hypertension, recurrent nephrolithiasis, and gout. Due to the size increment a neoplastic cystic lesion was considered and distal pancreatectomy was performed. Pathologic examination revealed a retention cyst associated with chronic pancreatitis and the presence of non-caseating granulomas consistent with sarcoidosis. In addition, a neuroendocrine adenoma, and an adjacent focus of pancreatic intraepithelial neoplasia-1 and 2 were noted.
    Discussion: Such presentations may be asymptomatic, as in this case, and a multidisciplinary workup is often required. Care must be taken to rule out pancreatic cancer. A possible relationship between pancreatic sarcoidosis and pancreatic cancer merits further study.
    Conclusion: The diagnosis of pancreatic sarcoidosis is difficult, and conclusive diagnosis requires histopathologic assessment.
    Language English
    Publishing date 2020-07-28
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2020.07.070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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