Article ; Online: Starting too soon: upstream reading frames repress downstream translation.
2016 Volume 35, Issue 7, Page(s) 699–700
Abstract: Upstream open reading frames (uORFs) are known to regulate a few specific transcripts, and recent ... on downstream translation. Furthermore, they show that regulatory uORFs are conserved across species and ... subject to selective constraint. Recognizing the potential of uORFs in regulating translation expands our understanding ...
| Abstract | Upstream open reading frames (uORFs) are known to regulate a few specific transcripts, and recent computational and experimental studies have suggested candidate uORF regulation across the genome. In this issue, Johnstone et al (2016) use ribosome profiling to identify translated uORFs and measure their effects on downstream translation. Furthermore, they show that regulatory uORFs are conserved across species and subject to selective constraint. Recognizing the potential of uORFs in regulating translation expands our understanding of the dynamic regulation of gene expression. |
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| MeSH term(s) | Animals ; Open Reading Frames ; Protein Biosynthesis ; Repressor Proteins/metabolism ; Vertebrates/genetics | ||||||||||
| Chemical Substances | Repressor Proteins | ||||||||||
| Language | English | ||||||||||
| Publishing date | 2016-04-01 | ||||||||||
| Publishing country | England | ||||||||||
| Document type | Comment ; Journal Article | ||||||||||
| ZDB-ID | 586044-1 | ||||||||||
| ISSN | 1460-2075 ; 0261-4189 | ||||||||||
| ISSN (online) | 1460-2075 | ||||||||||
| ISSN | 0261-4189 | ||||||||||
| DOI | 10.15252/embj.201693946 | ||||||||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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