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  1. Article ; Online: SARS-CoV-2 and Tacrolimus Blood Concentration in Kidney Transplant Recipients.

    McMinn, Jason / Black, Heather / Harrison, Luis Loureiro / Geddes, Colin

    Kidney international reports

    2021  Volume 6, Issue 10, Page(s) 2694–2697

    Language English
    Publishing date 2021-07-15
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2021.07.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Blood unconjugated bilirubin and tacrolimus are negative predictors of specific cellular immunity in kidney transplant recipients after SAR-CoV-2 inactivated vaccination.

    Zhang, Lei / Yang, Jiaqing / Deng, Min / Xu, Chuanhui / Lai, Changchun / Deng, Xuanying / Wang, Yan / Zhou, Qiang / Liu, Yichu / Wan, Li / Li, Pingchao / Fang, Jiali / Hou, Jingcai / Lai, Xingqiang / Ma, Feifei / Li, Ning / Li, Guanghui / Kong, Weiya / Zhang, Weiting /
    Li, Jiali / Cao, Mibu / Feng, Liqiang / Chen, Zheng / Chen, Ling / Ji, Tianxing

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 7263

    Abstract: The immunogenicity of SARS-CoV-2 vaccines is poor in kidney transplant recipients (KTRs ... logistic regression analysis found that blood unconjugated bilirubin and tacrolimus concentration were significantly ... of total bilirubin, unconjugated bilirubin, and blood tacrolimus concentrations. Multivariate ...

    Abstract The immunogenicity of SARS-CoV-2 vaccines is poor in kidney transplant recipients (KTRs). The factors related to poor immunogenicity to vaccination in KTRs are not well defined. Here, observational study demonstrated no severe adverse effects were observed in KTRs and healthy participants (HPs) after first or second dose of SARS-CoV-2 inactivated vaccine. Different from HPs with excellent immunity against SARS-CoV-2, IgG antibodies against S1 subunit of spike protein, receptor-binding domain, and nucleocapsid protein were not effectively induced in a majority of KTRs after the second dose of inactivated vaccine. Specific T cell immunity response was detectable in 40% KTRs after the second dose of inactivated vaccine. KTRs who developed specific T cell immunity were more likely to be female, and have lower levels of total bilirubin, unconjugated bilirubin, and blood tacrolimus concentrations. Multivariate logistic regression analysis found that blood unconjugated bilirubin and tacrolimus concentration were significantly negatively associated with SARS-CoV-2 specific T cell immunity response in KTRs. Altogether, these data suggest compared to humoral immunity, SARS-CoV-2 specific T cell immunity response are more likely to be induced in KTRs after administration of inactivated vaccine. Reduction of unconjugated bilirubin and tacrolimus concentration might benefit specific cellular immunity response in KTRs following vaccination.
    MeSH term(s) Female ; Humans ; Male ; Tacrolimus ; COVID-19 Vaccines ; Kidney Transplantation ; COVID-19/prevention & control ; SARS-CoV-2 ; Immunity, Cellular ; Bilirubin ; Immunity, Humoral ; Transplant Recipients ; Vaccination ; Antibodies, Viral
    Chemical Substances Tacrolimus (WM0HAQ4WNM) ; COVID-19 Vaccines ; Bilirubin (RFM9X3LJ49) ; Antibodies, Viral
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-29669-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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