Article ; Online: Fibrinolysis Shutdown in COVID-19: Clinical Manifestations, Molecular Mechanisms, and Therapeutic Implications.
Journal of the American College of Surgeons
2021 Volume 232, Issue 6, Page(s) 995–1003
Abstract: ... of fibrinolysis shutdown in COVID-19 and its associated outcomes, review the molecular mechanisms of dysregulated ... fibrinolysis associated with COVID-19, and discuss potential implications and therapeutic targets for patients ... resulting in a profoundly prothrombotic state, is a distinct feature of COVID-19 and is accentuated ...
| Abstract | The COVID-19 pandemic has introduced a global public health threat unparalleled in our history. The most severe cases are marked by ARDS attributed to microvascular thrombosis. Hypercoagulability, resulting in a profoundly prothrombotic state, is a distinct feature of COVID-19 and is accentuated by a high incidence of fibrinolysis shutdown. The aims of this review were to describe the manifestations of fibrinolysis shutdown in COVID-19 and its associated outcomes, review the molecular mechanisms of dysregulated fibrinolysis associated with COVID-19, and discuss potential implications and therapeutic targets for patients with severe COVID-19. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Blood Coagulation Disorders/etiology ; Blood Coagulation Disorders/therapy ; Blood Coagulation Disorders/virology ; COVID-19/blood ; COVID-19/complications ; Fibrinolysis ; Humans ; Thrombophilia/etiology ; Thrombophilia/therapy ; Thrombophilia/virology | |||||
| Language | English | |||||
| Publishing date | 2021-03-22 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 1181115-8 | |||||
| ISSN | 1879-1190 ; 1072-7515 | |||||
| ISSN (online) | 1879-1190 | |||||
| ISSN | 1072-7515 | |||||
| DOI | 10.1016/j.jamcollsurg.2021.02.019 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Uk I Zs.61: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.