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  1. Article ; Online: Myocarditis in COVID-19 patients: current problems.

    Mele, Donato / Flamigni, Filippo / Rapezzi, Claudio / Ferrari, Roberto

    Internal and emergency medicine

    2021  Volume 16, Issue 5, Page(s) 1123–1129

    Abstract: ... knowledge on myocarditis in COVID-19 patients and underline problems especially related to diagnosis and ... of myocarditis in the context of COVID-19. This brief review has the goal to revise and summarize current ... Myocarditis has been reported as a possible clinical presentation or complication in patients ...

    Abstract Myocarditis has been reported as a possible clinical presentation or complication in patients with coronavirus disease (COVID)-19 due to SARS-CoV-2. Despite the alarm that this possibility generated among physicians, there is paucity of information about mechanisms, prevalence, prognosis, diagnosis and therapy of myocarditis in the context of COVID-19. This brief review has the goal to revise and summarize current knowledge on myocarditis in COVID-19 patients and underline problems especially related to diagnosis and treatment.
    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; COVID-19/physiopathology ; Humans ; Myocarditis/epidemiology ; Myocarditis/etiology ; Prevalence
    Language English
    Publishing date 2021-01-23
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02635-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: COVID-19 Myocarditis: An Emerging Clinical Conundrum.

    Okor, Ivana / Bob-Manuel, Tamunoinemi / Price, Justin / Sleem, Amber / Amoran, Olayiwola / Kelly, Jayna / Ekerete, Markson Favour / Bamgbose, Micheal Olaseni / Bolaji, Olayiwola A / Krim, Selim R

    Current problems in cardiology

    2022  Volume 47, Issue 9, Page(s) 101268

    Abstract: ... in COVID-19 patients. ... Coronavirus Disease 2019 (COVID-19) has been a significant cause of global mortality and morbidity ... syndrome (ARDS). However, there is increasing evidence linking COVID-19 to cardiovascular complications ...

    Abstract Coronavirus Disease 2019 (COVID-19) has been a significant cause of global mortality and morbidity since it was first reported in December 2019 in Wuhan, China. COVID19 like previous coronaviruses primarily affects the lungs causing pneumonia, interstitial pneumonitis, and severe acute respiratory distress syndrome (ARDS). However, there is increasing evidence linking COVID-19 to cardiovascular complications such as arrhythmias, heart failure, cardiogenic shock, fulminant myocarditis, and cardiac death. Given the novelty of this virus, there is paucity of data on some cardiovascular complications of COVID-19, specifically myocarditis. Myocarditis is an inflammatory disease of the heart muscle with a heterogenous clinical presentation and progression. It is mostly caused by viral infections and is the result of interaction of the virus and the host's immune system. There have been several case reports linking COVID-19 with myocarditis, however the true mechanism of cardiac injury remains under investigation. In this paper we review the clinical presentation, proposed pathophysiology, differential diagnoses and management of myocarditis in COVID-19 patients.
    MeSH term(s) Arrhythmias, Cardiac ; COVID-19/complications ; Humans ; Myocarditis/diagnosis ; Myocarditis/etiology ; Myocarditis/therapy ; SARS-CoV-2 ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy
    Language English
    Publishing date 2022-05-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 441230-8
    ISSN 1535-6280 ; 0146-2806
    ISSN (online) 1535-6280
    ISSN 0146-2806
    DOI 10.1016/j.cpcardiol.2022.101268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Comparison of COVID-19 and Influenza-Associated Myocarditis: A Nationwide Study in the United States.

    Isath, Ameesh / Malik, Aaqib / Bandyopadhyay, Dhrubajyoti / Goel, Akshay / Hajra, Adrija / Contreras, Johanna / Lanier, Gregg M / Fonarow, Gregg C

    Current problems in cardiology

    2023  Volume 48, Issue 7, Page(s) 101680

    Abstract: ... from myocarditis was significantly higher in COVID-19 compared to influenza. Patients with myocarditis and COVID-19 ... with myocarditis and either concomitant corona virus disease 2019 (COVID-19) or influenza, and elucidate clinical ... from 2019 to 2020 to identify 27,725 adult myocarditis hospitalizations, of which 5840 had concomitant COVID ...

    Abstract We aimed to compare the characteristics and outcomes of adult patients hospitalized with myocarditis and either concomitant corona virus disease 2019 (COVID-19) or influenza, and elucidate clinical predictors associated with adverse outcomes in both groups. The study used the national inpatient sample (NIS) from 2019 to 2020 to identify 27,725 adult myocarditis hospitalizations, of which 5840 had concomitant COVID-19 and 1045 had concomitant influenza. After propensity score matching, the in-hospital mortality from myocarditis was significantly higher in COVID-19 compared to influenza. Patients with myocarditis and COVID-19 were more likely to have cardiovascular comorbidities and be older than those with influenza-associated myocarditis. Predictors of mortality were also different in both groups.
    MeSH term(s) Adult ; Humans ; United States/epidemiology ; Myocarditis/epidemiology ; Myocarditis/etiology ; Influenza, Human/complications ; Influenza, Human/epidemiology ; COVID-19/complications ; COVID-19/epidemiology ; Hospital Mortality ; Hospitalization
    Language English
    Publishing date 2023-03-12
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 441230-8
    ISSN 1535-6280 ; 0146-2806
    ISSN (online) 1535-6280
    ISSN 0146-2806
    DOI 10.1016/j.cpcardiol.2023.101680
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  4. Article ; Online: Nationwide Analysis of the Clinical Outcomes of Patients Admitted With COVID-19 Infection With Myocarditis and Racial Disparities in Mortality.

    Cannon, Harmon R / Bobba, Aniesh / Shekhar, Rahul / Gangu, Karthik / Sagheer, Shazib / Chourasia, Prabal / Garg, Ishan / Shuja, Hina / Wasty, Najam / Sheikh, Abu Baker

    Current problems in cardiology

    2022  Volume 48, Issue 2, Page(s) 101481

    Abstract: ... Patients with COVID-19 and Myocarditis had higher in-hospital mortality compared to those with Myocarditis ... including the cardiovascular system. The relationship between COVID-19 and Myocarditis has been well ... established, but there are limited large-scale studies evaluating outcome of COVID-19 related Myocarditis ...

    Abstract Coronavirus-19 (COVID-19), while primarily a respiratory virus, affects multiple organ systems, including the cardiovascular system. The relationship between COVID-19 and Myocarditis has been well established, but there are limited large-scale studies evaluating outcome of COVID-19 related Myocarditis. Using National Inpatient Sample (NIS) database, we compared patients with Myocarditis with and without COVID-19 infection. The primary outcome was in-hospital mortality. Secondary outcomes were acute kidney injury requiring hemodialysis, vasopressor use, mechanical ventilation, cardiogenic shock, mechanical circulatory support, sudden cardiac arrest, and length of hospitalization. A total of 17,970 patients were included in study; Myocarditis without COVID (n = 11,515, 64%) and Myocarditis with COVID-19 (n = 6,455, 36%). Patients with COVID-19 and Myocarditis had higher in-hospital mortality compared to those with Myocarditis alone (30.7% vs 6.4%, odds ratio 4.8, 95% CI 3.7-6.3, P< 0.001). That cohort also had significantly higher rates of vasopressor use, mechanical ventilation, sudden cardiac arrest, and acute kidney injury requiring hemodialysis. Given the poor outcome seen in COVID-19 related Myocarditis cohort, further work is needed for development of directed therapies for COVID-19-related Myocarditis.
    MeSH term(s) Humans ; Myocarditis/therapy ; COVID-19/complications ; COVID-19/therapy ; Hospitalization ; Death, Sudden, Cardiac ; Acute Kidney Injury/epidemiology ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy
    Language English
    Publishing date 2022-11-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 441230-8
    ISSN 1535-6280 ; 0146-2806
    ISSN (online) 1535-6280
    ISSN 0146-2806
    DOI 10.1016/j.cpcardiol.2022.101481
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Fulminant myocarditis in a patient with a lung adenocarcinoma after the third dose of modern COVID-19 vaccine. A case report and literature review.

    Terán Brage, Eduardo / Roldán Ruíz, Jonnathan / González Martín, Javier / Oviedo Rodríguez, Juan Diego / Vidal Tocino, Rosario / Rodríguez Diego, Sara / Sánchez Hernández, Pedro Luis / Bellido Hernández, Lorena / Fonseca Sánchez, Emilio

    Current problems in cancer. Case reports

    2022  Volume 6, Page(s) 100153

    Abstract: ... administration of the third dose of Moderna® COVID-19 vaccine in the context of acute myocarditis with evidence ... COVID-19 vaccine in a patient diagnosed with metastatic lung adenocarcinoma on treatment ... Introduction COVID-19 disease has caused a global health and economic crisis. The introduction ...

    Abstract Introduction COVID-19 disease has caused a global health and economic crisis. The introduction of the different COVID-19 vaccines has resulted in a significant decrease in the morbidity and mortality associated with this disease. Adverse effects have been reported, including cardiological ones such as myocarditis or pericarditis after administration. Likewise, tyrosine kinase inhibitor drugs such as osimertinib used in lung cancer patients with epidermal growth factor receptor (EGFR) mutation are associated with heart failure or prolongation of the QT interval. Case report 62-year-old woman diagnosed in September 2019 of lung adenocarcinoma stage IV with bilateral lung and lymph node involvement, carrier of an EGFR mutation (Ex19Del) on treatment with osimertinib. She attended emergency department for fever and hypotension 24 h after administration of the third dose of Moderna® COVID-19 vaccine in the context of acute myocarditis with evidence of severe left ventricular (LV) dysfunction in cardiogenic shock. She required vasoactive support, non-invasive mechanical ventilation, corticotherapy, immunoglobulins and subsequent ventricular support with Impella, with improvement of the clinical picture after 3 days. Cardiac magnetic resonance imaging (MRI) showed evidence of global myocardial oedema compatible with acute myocarditis. Coronary CT showed a lesion in the anterior descending coronary artery requiring revascularization. A few days later, she presented febrile symptoms with isolation of Staphylococcus aureus in the central line catheter and antibiotherapy with cloxacillin was started, with subsequent resolution of the infectious symptoms. Conclusion This is an exceptional and controversial case of fulminant myocarditis probably related to the Modern COVID-19 vaccine in a patient diagnosed with metastatic lung adenocarcinoma on treatment with osimertinib. An increasing number of cases of myocarditis and pericarditis have been reported following vaccination with COVID-19 mRNA vaccines. In addition, retrospective data have shown an increased risk of QT prolongation and heart failure in patients treated with tyrosine kinase inhibitors. Hence, the need for close monitoring of cardiac function during treatment of these patients. Future studies will be necessary to evaluate unknown adverse reactions of these vaccines and their possible interaction with other antineoplastic drugs.
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Case Reports
    ISSN 2666-6219
    ISSN (online) 2666-6219
    DOI 10.1016/j.cpccr.2022.100153
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