Article ; Online: Metformin and SARS-CoV-2: mechanistic lessons on air pollution to weather the cytokine/thrombotic storm in COVID-19.
Aging
2020 Volume 12, Issue 10, Page(s) 8760–8765
Abstract: ... coronavirus SARS-CoV-2. Metformin is capable of suppressing one of the molecular triggers ... of the proinflammatory and prothrombotic processes of urban PM air pollution, namely the mitochondrial ROS/Ca ... Pathological signaling in the lung induced by particulate matter (PM) air pollution partially ...
| Abstract | Pathological signaling in the lung induced by particulate matter (PM) air pollution partially overlaps with that provoked by COVID-19, the pandemic disease caused by infection with the novel coronavirus SARS-CoV-2. Metformin is capable of suppressing one of the molecular triggers of the proinflammatory and prothrombotic processes of urban PM air pollution, namely the mitochondrial ROS/Ca |
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| MeSH term(s) | Aged ; Betacoronavirus/physiology ; COVID-19 ; Calcium Release Activated Calcium Channels/metabolism ; Coronavirus Infections/blood ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Drug Repositioning/methods ; Humans ; Hypoglycemic Agents/pharmacokinetics ; Hypoglycemic Agents/therapeutic use ; Inflammation/drug therapy ; Inflammation/metabolism ; Interleukin-6/immunology ; Metformin/pharmacokinetics ; Metformin/therapeutic use ; Pandemics ; Particulate Matter/immunology ; Pneumonia, Viral/blood ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; Reactive Oxygen Species/immunology ; SARS-CoV-2 ; Signal Transduction/drug effects ; Thrombosis/drug therapy ; Thrombosis/metabolism |
| Chemical Substances | Calcium Release Activated Calcium Channels ; Hypoglycemic Agents ; Interleukin-6 ; Particulate Matter ; Reactive Oxygen Species ; Metformin (9100L32L2N) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-05-27 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 1945-4589 |
| ISSN (online) | 1945-4589 |
| DOI | 10.18632/aging.103347 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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