Article ; Online: TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway.
2013 Volume 333, Issue 1, Page(s) 96–102
Abstract: ... decrease in migration and invasion capability of MDA-MB-435 breast cancer cells, and phosphorylation levels ... of Src and MAPK but not AKT. Our results suggest that TRPM7 regulates migration and invasion ... of metastatic breast cancer cells via MAPK pathway. ...
| Abstract | Metastasis is an inherent feature of breast cancer and transient receptor potential (TRP) channels were found to be potentially implicated in this process. Particularly, TRPM7 may regulate cell motility. We therefore examined the expression of TRPM7 mRNA in the Oncomine database and found that TRPM7 is correlated to metastasis and invasive breast cancer. Silencing TRPM7 with RNA interference resulted in a significant decrease in migration and invasion capability of MDA-MB-435 breast cancer cells, and phosphorylation levels of Src and MAPK but not AKT. Our results suggest that TRPM7 regulates migration and invasion of metastatic breast cancer cells via MAPK pathway. |
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| MeSH term(s) | Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement ; Female ; Humans ; MAP Kinase Signaling System/physiology ; Neoplasm Invasiveness ; Phosphatidylinositol 3-Kinases/physiology ; Protein-Serine-Threonine Kinases ; Proto-Oncogene Proteins c-akt/physiology ; RNA, Small Interfering/genetics ; TRPM Cation Channels/physiology |
| Chemical Substances | RNA, Small Interfering ; TRPM Cation Channels ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TRPM7 protein, human (EC 2.7.11.1) |
| Language | English |
| Publishing date | 2013-06-01 |
| Publishing country | Ireland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 195674-7 |
| ISSN | 1872-7980 ; 0304-3835 |
| ISSN (online) | 1872-7980 |
| ISSN | 0304-3835 |
| DOI | 10.1016/j.canlet.2013.01.031 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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