Article ; Online: Interaction between thrombin potential and age on early clinical outcome in patients hospitalized for COVID-19.
Journal of thrombosis and thrombolysis
2021 Volume 52, Issue 3, Page(s) 746–753
Abstract: Patients with Coronavirus Disease-2019 (COVID-19) have haemostatic dysfunction and are at higher ... Consortium (BARC) definition] during in-hospital stay. COVID-19 patients had similar ETP levels compared ... to controls (AUC 93 ± 24% vs 99 ± 21%, p = 0.339). In the COVID-19 cohort, patients with in-hospital MACE ...
| Abstract | Patients with Coronavirus Disease-2019 (COVID-19) have haemostatic dysfunction and are at higher risk of thrombotic complications. Although age is a major risk factor for outcome impairment in COVID-19, its impact on coagulative patterns here is still unclear. We investigated the association of Endogenous Thrombin Potential (ETP) with thrombotic and haemorrhagic events according to different ages in patients admitted for COVID-19. A total of 27 patients with COVID-19-related pneumonia, without need for intensive care unit admission or mechanical ventilation at hospital presentation, and 24 controls with non-COVID-19 pneumonia were prospectively included. ETP levels were measured on admission. Patients were evaluated for major adverse cardiovascular events (MACE: cardiovascular death, myocardial infarction, stroke, transient ischemic attack, venous thromboembolism) and bleeding complications [according to Bleeding Academic Research Consortium (BARC) definition] during in-hospital stay. COVID-19 patients had similar ETP levels compared to controls (AUC 93 ± 24% vs 99 ± 21%, p = 0.339). In the COVID-19 cohort, patients with in-hospital MACE showed lower ETP levels on admission vs those without (AUC 86 ± 14% vs 95 ± 27%, p = 0.041), whereas ETP values were comparable in patients with or without bleeding (AUC 82 ± 16% vs 95 ± 26%, p = 0.337). An interaction between age and ETP levels for both MACE and bleeding complications was observed, where a younger age was associated with an inverse relationship between ETP values and adverse event risk (p |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Age Factors ; Aged ; Aged, 80 and over ; Biomarkers/blood ; COVID-19/blood ; COVID-19/complications ; COVID-19/mortality ; COVID-19/therapy ; Case-Control Studies ; Female ; Hemostasis ; Hospitalization ; Humans ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Risk Assessment ; Risk Factors ; Thrombin/metabolism ; Thrombosis/blood ; Thrombosis/etiology ; Thrombosis/mortality ; Thrombosis/therapy ; Time Factors | |||||
| Chemical Substances | Biomarkers ; Thrombin (EC 3.4.21.5) | |||||
| Language | English | |||||
| Publishing date | 2021-06-10 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article ; Observational Study | |||||
| ZDB-ID | 1230645-9 | |||||
| ISSN | 1573-742X ; 0929-5305 | |||||
| ISSN (online) | 1573-742X | |||||
| ISSN | 0929-5305 | |||||
| DOI | 10.1007/s11239-021-02497-1 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 4352: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.