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  1. Article ; Online: Natural and pharmacological regulation of telomerase.

    Mergny, Jean-Louis / Riou, Jean-François / Mailliet, Patrick / Teulade-Fichou, Marie-Paule / Gilson, Eric

    Nucleic acids research

    2002  Volume 30, Issue 4, Page(s) 839–865

    Abstract: ... expressed in tumour cells but not in most somatic cells and thus telomeres and telomerase may be proposed ... telomerase, a specialised reverse transcriptase necessary to fully duplicate the telomeric DNA. Telomerase is ...

    Abstract The extremities of eukaryotic chromosomes are called telomeres. They have a structure unlike the bulk of the chromosome, which allows the cell DNA repair machinery to distinguish them from 'broken' DNA ends. But these specialised structures present a problem when it comes to replicating the DNA. Indeed, telomeric DNA progressively erodes with each round of cell division in cells that do not express telomerase, a specialised reverse transcriptase necessary to fully duplicate the telomeric DNA. Telomerase is expressed in tumour cells but not in most somatic cells and thus telomeres and telomerase may be proposed as attractive targets for the discovery of new anticancer agents.
    MeSH term(s) Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Humans ; Mice ; Models, Genetic ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Telomerase/antagonists & inhibitors ; Telomerase/metabolism
    Chemical Substances Antineoplastic Agents ; Enzyme Inhibitors ; Telomerase (EC 2.7.7.49)
    Language English
    Publishing date 2002-01-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/30.4.839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Book ; Online: Theme Issue Honoring Professor Robert Verpoorte’s 75th Birthday: Past, Current and Future of Natural Products Research

    Choi, Young Hae / Jang, Young Pyo / Dai, Yuntao / Salomé-Abarca, Luis Francisco

    2021  

    Keywords Research & information: general ; natural extract ; glycerin ; chemical profiling ; centrifugal partition chromatography ; 13C nuclear magnetic resonance ; cosmetic industry ; Psychotria malayana Jack ; type 2 diabetes ; α-glucosidase inhibitors ; LC-MS ; metabolomics ; molecular docking ; colorectal cancer ; HCT 116 ; telomerase ; telomerase inhibitor ; berberine ; downregulation ; cell cycle arrest ; telomere erosion ; molecular imaging ; direct analysis in real-time mass spectrometry ; ephedra alkaloids ; ephedrine ; methylephedrine ; Ephedra sinica ; natural products ; dereplication ; databases ; spectroscopy ; taxonomy ; molecular structures ; lignans ; secoisolariciresinol ; RNA interference ; flax ; osmotic stress ; 1H-NMR ; ionic liquids ; oxypeucedanin hydrate ; byakangelicin ; A. dahurica ; back-extraction ; enrichment ; plum brandy ; GC-FID-MS ; enzyme inhibition assay ; antibacterial assay ; effect-directed analysis ; bioassay ; botanicals ; health food ; protein tyrosine phosphatases (PTPs) ; PTP-MEG2 ; phloridzin ; glucose-uptake ; Eleutherococcus senticosus ; fruits ; eleutherosides ; nutri-pharmacological ; herbs ; inflammation ; docking ; NuBBE database ; chalcones ; Nacobbus aberrans ; nematicidal activity ; α-terthienyl ; stigmasterol ; quercetagetin derivatives ; 9-O-angeloyl-retronecine N-oxide ; alkaloid ; Solanaceae ; tropane ; indole ; pyrrolidine ; Datura ; terpenoid ; signaling ; chemical cue ; kairomone ; potentiation ; cytotoxic activity ; NMR ; Ononis diffusa ; Ononis variegata ; oxylipins ; toronjil ; Mexican agastache ; aromatic plants ; weld ; Reseda luteola L. ; natural yellow dye ; μ-analysis ; micro-extraction of wool ; UHPLC ; fingerprinting ; flavones ; structure elucidation ; n/a
    Size 1 electronic resource (328 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021291373
    ISBN 9783036527437 ; 3036527435
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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