Article: Polyglandular autoimmune syndrome: current concepts.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
1988 Volume 138, Issue 7, Page(s) 605–612
Abstract: The polyglandular autoimmune syndrome (PGAS) is characterized by the association of two or more ... autoantibodies are frequently detected in patients with the syndrome and may be a marker of future organ failure ... PGAS should be considered in patients with one or more of the disorders constituting the syndrome ...
| Abstract | The polyglandular autoimmune syndrome (PGAS) is characterized by the association of two or more endocrine disorders that are mediated by autoimmune mechanisms and usually lead to a hypofunctional state. In this review we classify the various types of PGAS and discuss their clinical features and the pathophysiologic autoimmune mechanisms that are thought to play an important role. Circulating organ- and cell-specific autoantibodies are frequently detected in patients with the syndrome and may be a marker of future organ failure. PGAS should be considered in patients with one or more of the disorders constituting the syndrome; this should facilitate early diagnosis and perhaps even prevention of other components of the disease. Early recognition and replacement therapy can be life-saving, particularly when there is adrenal or thyroid insufficiency. |
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| MeSH term(s) | Autoantibodies/analysis ; Autoimmune Diseases/classification ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Endocrine System Diseases/classification ; Endocrine System Diseases/genetics ; Endocrine System Diseases/immunology ; Female ; Humans ; Immunity, Cellular ; Male ; Syndrome | |||||
| Chemical Substances | Autoantibodies | |||||
| Language | English | |||||
| Publishing date | 1988-04-01 | |||||
| Publishing country | Canada | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review | |||||
| ZDB-ID | 215506-0 | |||||
| ISSN | 1488-2329 ; 0820-3946 ; 0008-4409 | |||||
| ISSN (online) | 1488-2329 | |||||
| ISSN | 0820-3946 ; 0008-4409 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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