Article ; Online: Non-invasive intranasal administration route directly to the brain using dendrimer nanoplatforms: An opportunity to develop new CNS drugs.
European journal of medicinal chemistry
2020 Volume 209, Page(s) 112905
Abstract: ... drugs to the brain. Importantly, intranasal (IN) administration can allow direct delivery of drugs ... to deliver CNS drugs directly via IN. This review highlighed the few examples of the association of dendrimer ... In this regard, dendrimers may possess great potential to deliver drugs to the brain by IN administration ...
| Abstract | There are several routes of administration to the brain, including intraparenchymal, intraventricular, and subarachnoid injections. The blood-brain barrier (BBB) impedes the permeation and access of most drugs to the central nervous system (CNS), and consequently, many neurological diseases remain undertreated. For past decades, to circumvent this effect, several nanocarriers have been developed to deliver drugs to the brain. Importantly, intranasal (IN) administration can allow direct delivery of drugs into the brain through the anatomical connection between the nasal cavity and brain without crossing the BBB. In this regard, dendrimers may possess great potential to deliver drugs to the brain by IN administration, bypassing the BBB and reducing systemic exposure and side effects, to treat diseases of the CNS. In this original concise review, we highlighted the few examples advocated regarding the use of dendrimers to deliver CNS drugs directly via IN. This review highlighed the few examples of the association of dendrimer encapsulating drugs (e.g., small compounds: haloperidol and paeonol; macromolecular compounds: dextran, insulin and calcitonin; and siRNA) using IN administration. Good efficiencies were observed. In addition, we will present the in vivo effects of PAMAM dendrimers after IN administration, globally, showing no general toxicity. |
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| MeSH term(s) | Acetophenones/administration & dosage ; Acetophenones/chemistry ; Administration, Intranasal ; Animals ; Biological Transport ; Blood-Brain Barrier/metabolism ; Calcitonin/administration & dosage ; Calcitonin/chemistry ; Central Nervous System Agents/pharmacology ; Dendrimers/chemistry ; Dextrans/administration & dosage ; Dextrans/chemistry ; Drug Liberation ; Haloperidol/administration & dosage ; Haloperidol/chemistry ; Humans ; Insulin/administration & dosage ; Insulin/chemistry ; Nanocapsules/chemistry ; RNA, Small Interfering/administration & dosage ; RNA, Small Interfering/chemistry ; Technology, Pharmaceutical | |||||
| Chemical Substances | Acetophenones ; Central Nervous System Agents ; Dendrimers ; Dextrans ; Insulin ; Nanocapsules ; PAMAM Starburst ; RNA, Small Interfering ; paeonol (3R834EPI82) ; Calcitonin (9007-12-9) ; Haloperidol (J6292F8L3D) | |||||
| Keywords | covid19 | |||||
| Language | English | |||||
| Publishing date | 2020-10-11 | |||||
| Publishing country | France | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 188597-2 | |||||
| ISSN | 1768-3254 ; 0009-4374 ; 0223-5234 | |||||
| ISSN (online) | 1768-3254 | |||||
| ISSN | 0009-4374 ; 0223-5234 | |||||
| DOI | 10.1016/j.ejmech.2020.112905 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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