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  1. Article ; Online: Gene expression regulation: lessons from noncoding RNAs.

    Mihailescu, Rita

    RNA (New York, N.Y.)

    2015  Volume 21, Issue 4, Page(s) 695–696

    MeSH term(s) 3' Untranslated Regions ; Gene Expression Regulation ; RNA, Untranslated/genetics
    Chemical Substances 3' Untranslated Regions ; RNA, Untranslated
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1241540-6
    ISSN 1469-9001 ; 1355-8382
    ISSN (online) 1469-9001
    ISSN 1355-8382
    DOI 10.1261/rna.050815.115
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Former orphan riboswitches reveal unexplored areas of bacterial metabolism, signaling, and gene control processes.

    Sherlock, Madeline E / Breaker, Ronald R

    RNA (New York, N.Y.)

    2020  Volume 26, Issue 6, Page(s) 675–693

    Abstract: ... RNAs, some of which are riboswitches that specifically recognize small-molecule or elemental ion ... ligands with orphan riboswitch classes, and overview the lessons learned to inform and motivate ongoing ... Comparative sequence analyses have been used to discover numerous classes of structured noncoding ...

    Abstract Comparative sequence analyses have been used to discover numerous classes of structured noncoding RNAs, some of which are riboswitches that specifically recognize small-molecule or elemental ion ligands and influence expression of adjacent downstream genes. Determining the correct identity of the ligand for a riboswitch candidate typically is aided by an understanding of the genes under its regulatory control. Riboswitches whose ligands were straightforward to identify have largely been associated with well-characterized metabolic pathways, such as coenzyme or amino acid biosynthesis. Riboswitch candidates whose ligands resist identification, collectively known as orphan riboswitches, are often associated with genes coding for proteins of unknown function, or genes for various proteins with no established link to one another. The cognate ligands for 16 former orphan riboswitch motifs have been identified to date. The successful pursuit of the ligands for these classes has provided insight into areas of biology that are not yet fully explored, such as ion homeostasis, signaling networks, and other previously underappreciated biochemical or physiological processes. Herein we discuss the strategies and methods used to match ligands with orphan riboswitch classes, and overview the lessons learned to inform and motivate ongoing efforts to identify ligands for the many remaining candidates.
    MeSH term(s) Bacteria/genetics ; Bacteria/metabolism ; Gene Expression Regulation, Bacterial ; Ligands ; Metabolic Networks and Pathways/genetics ; Nucleotide Motifs ; Riboswitch ; Signal Transduction
    Chemical Substances Ligands ; Riboswitch
    Language English
    Publishing date 2020-03-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1241540-6
    ISSN 1469-9001 ; 1355-8382
    ISSN (online) 1469-9001
    ISSN 1355-8382
    DOI 10.1261/rna.074997.120
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4777: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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