Article ; Online: Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability.
2020 Volume 11, Issue 5
Abstract: Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl ... of different HDACs and discuss their role in the human interactome as members of chromatin-binding and ... focusing on the role of HDAC inhibitors as anti-cancer agents. We will investigate the chemical specificity ...
| Abstract | Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here a review on the recent knowledge accrued on the zinc-dependent HDAC protein family across different species, tissues, and human pathologies, specifically focusing on the role of HDAC inhibitors as anti-cancer agents. We will investigate the chemical specificity of different HDACs and discuss their role in the human interactome as members of chromatin-binding and regulatory complexes. |
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| MeSH term(s) | Antineoplastic Agents/therapeutic use ; Histone Deacetylase Inhibitors/therapeutic use ; Histone Deacetylases/genetics ; Histones/genetics ; Humans ; Neoplasms/genetics ; Neoplasms/therapy ; Substrate Specificity/genetics ; Transcription Factors/genetics |
| Chemical Substances | Antineoplastic Agents ; Histone Deacetylase Inhibitors ; Histones ; Transcription Factors ; Histone Deacetylases (EC 3.5.1.98) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-05-15 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 2527218-4 |
| ISSN | 2073-4425 ; 2073-4425 |
| ISSN (online) | 2073-4425 |
| ISSN | 2073-4425 |
| DOI | 10.3390/genes11050556 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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