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Article ; Online: Pediatric melanoma: a review.

Mills, Omie / Messina, Jane L

Cancer control : journal of the Moffitt Cancer Center

2009 Volume 16, Issue 3, Page(s) 225–233

Abstract: ... pathologic features of pediatric melanoma, highlighting the similarities and differences between adult and ... pediatric melanoma.: Results: Distinctive features of this disease, including frequency and type ... melanoma trials, are also discussed.: Conclusions: Despite the differences between pediatric and adult ...

Abstract	Background: Malignant melanoma is a rare neoplasm in the pediatric population, but its incidence has risen in recent years. Methods: The literature was reviewed to define the current clinical and pathologic features of pediatric melanoma, highlighting the similarities and differences between adult and pediatric melanoma. Results: Distinctive features of this disease, including frequency and type of genetic abnormalities, predisposing conditions, clinical presentation, stage at diagnosis, prognostic features, and frequency of sentinel lymph node positivity are emphasized. Treatment strategies, extrapolated from adult melanoma trials, are also discussed. Conclusions: Despite the differences between pediatric and adult melanoma, survival rates are similar and are improving in both populations. Further studies will help delineate the pathogenesis of both adult and pediatric melanoma, with the goal of contributing to early detection and improved survival.
MeSH term(s)	Adolescent ; Age Distribution ; Child ; Child, Preschool ; Diagnosis, Differential ; Female ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Melanoma/classification ; Melanoma/epidemiology ; Melanoma/pathology ; Melanoma/therapy ; Prognosis ; Risk Factors ; Sentinel Lymph Node Biopsy ; Skin Neoplasms/classification ; Skin Neoplasms/epidemiology ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy
Language	English
Publishing date	2009-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1328503-8
ISSN	1526-2359 ; 1073-2748
ISSN (online)	1526-2359
ISSN	1073-2748
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Article ; Online: Pediatric Primary Intracranial Malignant Melanoma: Case Report and Literature Review.

Lim, Mervyn J R / Tan, Enrica E K / Wong, Ru Xin / Chang, Kenneth T E / Fortier, Marielle V / Cheong, Tien Meng / Ng, Lee Ping / Low, Sharon Y Y

Pediatric neurosurgery

2023 Volume 58, Issue 4, Page(s) 223–230

Abstract: Introduction: Primary intracranial malignant melanoma (PIMM) is an extremely rare ... workup for cutaneous, uveal, and visceral malignant melanoma was negative. A trial of whole-brain ... primary brain tumor with most cases diagnosed in adults. To date, there are only a few cases reported in the pediatric ...

Abstract	Introduction: Primary intracranial malignant melanoma (PIMM) is an extremely rare primary brain tumor with most cases diagnosed in adults. To date, there are only a few cases reported in the pediatric population. Owing to its infrequency, there are no established guidelines to treat this aggressive neoplasm. Recent insights suggest that PIMM are molecularly different between adults and children, whereby NRAS mutations drive tumor growth in the latter group. We present a unique case of PIMM in a pediatric patient and discuss the case in corroboration with current literature. Case presentation: A previously well 15-year-old male presented with progressive symptoms of raised intracranial pressure. Neuroimaging reported a large solid-cystic lesion with significant mass effect. He underwent gross total resection of the lesion that was reported to be a PIMM with pathogenic single nucleotide variant NRAS p.Gln61Lys. Further workup for cutaneous, uveal, and visceral malignant melanoma was negative. A trial of whole-brain radiotherapy followed by dual immune checkpoint inhibitors was commenced. Despite concerted efforts, the patient had aggressive tumor progression and eventually demised from his disease. Conclusion: We therein report a case of pediatric PIMM, in the context of the patient's clinical, radiological, histopathological, and molecular findings. This case highlights the therapeutic difficulties faced in disease management and contributes to the very limited pool of medical literature for this devastating primary brain tumor.
MeSH term(s)	Male ; Adult ; Humans ; Child ; Adolescent ; Melanoma/diagnostic imaging ; Melanoma/surgery ; Melanoma/genetics ; Skin Neoplasms ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/surgery
Language	English
Publishing date	2023-06-14
Publishing country	Switzerland
Document type	Review ; Case Reports
ZDB-ID	1091757-3
ISSN	1423-0305 ; 1016-2291
ISSN (online)	1423-0305
ISSN	1016-2291
DOI	10.1159/000531544
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Article ; Online: A Review of Pediatric Ophthalmic Tumors.

Yeager, Lauren B / Kassotis, Alexis / Frank, Tahvi / Li, Chloe Y / Marr, Brian P

Pediatrics in review

2024 Volume 45, Issue 3, Page(s) 119–131

Abstract: ... into the following categories for review: anterior tumors of the eyelid and ocular surface, orbital tumors, and ... immediate referral to an ophthalmologist for initiation of further testing. We aimed to review ... Tumors of the eye, orbit, and ocular adnexa can arise in the pediatric population. These entities ...

Abstract	Tumors of the eye, orbit, and ocular adnexa can arise in the pediatric population. These entities can be both vision- and life-threatening and may be associated with systemic disease. Given their relative rarity, pediatricians must be aware of these conditions and understand what findings warrant immediate referral to an ophthalmologist for initiation of further testing. We aimed to review these conditions and highlight clinical features to promote awareness and expedite diagnosis. Tumors are subdivided into the following categories for review: anterior tumors of the eyelid and ocular surface, orbital tumors, and intraocular tumors.
MeSH term(s)	Humans ; Child ; Eye Neoplasms/diagnosis ; Eye Neoplasms/therapy ; Orbital Neoplasms/diagnosis ; Face
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	774515-1
ISSN	1526-3347 ; 0191-9601
ISSN (online)	1526-3347
ISSN	0191-9601
DOI	10.1542/pir.2023-006163
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Zs.B 2595: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Regional lymph node evaluation in pediatric conventional melanoma subtype: a single-center 10-year review.

Sutthatarn, Pattamon / Davidoff, Andrew M / Bahrami, Armita / Richard, Celine / Shalini, Bhatia / Santiago, Teresa C / Shulkin, Barry L / Pappo, Alberto S / Abdelhafeez, Abdelhafeez

Pediatric surgery international

2024 Volume 40, Issue 1, Page(s) 68

Abstract: ... and completion lymph node dissection (CLND) in pediatric conventional melanoma (CM), while evaluating ... melanoma.: Results: Among the 33 patients, SLNB detected metastasis in 57.6% of cases, with 52.6 ... melanoma. Further multicenter trials are needed to confirm our single-institution experience.: Level ...

Abstract	Purpose: To assess the prognostic and therapeutic significance of sentinel lymph node biopsy (SLNB) and completion lymph node dissection (CLND) in pediatric conventional melanoma (CM), while evaluating potential predictive factors for outcomes. Methods: We conducted a retrospective analysis of medical records spanning 2009-2020, focusing on patients aged 18 or younger with localized cutaneous conventional melanoma. Results: Among the 33 patients, SLNB detected metastasis in 57.6% of cases, with 52.6% undergoing CLND. Positive SLN patients had higher relapse risk (HR 5.92; 95% CI 1.27-27.7; P = 0.024) but similar overall survival (HR 3.19; 95% CI 0.31-33.1, P = 0.33). No significant differences in disease-free survival (DFS) and OS were found between patients who underwent CLND and those who did not (HR 1.91; 95% CI 0.49-7.43, P = 0.35, and HR 0.52; 95% CI 0.03-8.32, P = 0.64, respectively). Univariate analysis showed age at diagnosis (P = 0.02) correlated with higher recurrence risk, with a 21% hazard increase per additional year of age. Conclusions: Positive SLN status and age at diagnosis were associated with worse DFS in CM patients. Our study did not find any prognostic or therapeutic value in CLND for pediatric melanoma. Further multicenter trials are needed to confirm our single-institution experience. Level of evidence: Level IV.
MeSH term(s)	Humans ; Child ; Melanoma/surgery ; Retrospective Studies ; Lymph Nodes ; Skin Neoplasms/surgery ; Disease-Free Survival
Language	English
Publishing date	2024-03-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	632773-4
ISSN	1437-9813 ; 0179-0358
ISSN (online)	1437-9813
ISSN	0179-0358
DOI	10.1007/s00383-024-05646-8
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Zs.A 2138: Show issues

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Article ; Online: Melanoma-like features in pediatric longitudinal melanonychia: A systematic review and meta-analysis.

Tsai, Serena Yun-Chen / Hamilton, Claire E / Mologousis, Mia A / Hawryluk, Elena B

Pediatric dermatology

2024

Abstract: ... flag signs for subungual melanoma in adults and lead to diagnostic uncertainty. Nail biopsy may be ... spontaneous regression (narrowing or fading, 19.9%). Only eight cases of subungual melanoma in situ were ... articles, reviews, and abstracts were excluded. We performed a systematic review and meta-analysis ...

Abstract	Background: Pediatric longitudinal melanonychia (LM) can exhibit atypical features that mimic red-flag signs for subungual melanoma in adults and lead to diagnostic uncertainty. Nail biopsy may be unnecessary if clinical inspection and dermoscopy suggest a benign nature. Methods: We searched PubMed and Embase from inception to February 2023 for studies of any design reporting either the number or proportion of clinical and dermoscopic features in at least five children (≤18 years) with LM. Non-English articles, reviews, and abstracts were excluded. We performed a systematic review and meta-analysis to collate all existing data. Results: A total of 1218 articles were screened and 24 studies with 1391 pediatric patients were included. Nevus was the most common diagnosis (86.3%). The most prevalent sites were fingernails (76.2%) and first digits (45.4%). Pooled proportions of common features were: dark-color bands (69.8%), multi-colored bands (47.6%), broad bandwidth (41.1%), pseudo-Hutchinson sign (41.0%), irregular patterns (38.1%), Hutchinson sign (23.7%), dots and globules (22.5%), nail dystrophy (18.2%), and triangular sign (10.9%). Outcomes included progression (widening or darkening, 29.9%), stability (23.3%), and spontaneous regression (narrowing or fading, 19.9%). Only eight cases of subungual melanoma in situ were reported, and no invasive melanomas were identified. Conclusion: Although atypical characteristics are common in pediatric LM, the probability of malignant transformation is exceedingly low. Appropriate evaluation and management of pediatric LM includes careful clinical and dermoscopic inspection with attention to benign features followed by long-term interval follow-up.
Language	English
Publishing date	2024-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	605539-4
ISSN	1525-1470 ; 0736-8046
ISSN (online)	1525-1470
ISSN	0736-8046
DOI	10.1111/pde.15597
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Zs.A 1882: Show issues

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Book: Pediatric Neuropsychology

Hodges, Elise K / Kuentzel, Jeffrey G / Hook, Julie N

Perspectives from the Ambulatory Care Setting

(Studies on Neuropsychology, Development, and Cognition)

2018

Abstract: ... information on these pediatric neurodevelopmental and medical disorders, including a review ... Pediatric Neuropsychology: Perspectives in an Ambulatory Care Setting provides an overview ...

Author's details	Elise K. Hodges Ph.D. is a clinical neuropsychologist and associate professor at Michigan Medicine. Her research and clinical work focuses on neuropsychological sequelae of medical disorders primarily in children and adolescents. Jeffrey Kuentzel, Ph.D. is a licensed psychologist and Director of Wayne State University's Counseling and Psychological Services (CAPS). He is an expert in Dialectical Behavior Therapy and Motivational Interviewing. Julie N. Hook, Ph.D., MBA. ABPP-CN is Research Associate Professor and the NIH Toolbox® Product Manager in the Department of Medical Social Sciences at the Feinberg School of Medicine, Northwestern University. In her current role, she contributes to NIH grant-funded research, and oversees the NIH Toolbox® product portfolio
Series title	Studies on Neuropsychology, Development, and Cognition
Abstract	Pediatric Neuropsychology: Perspectives in an Ambulatory Care Setting provides an overview of the most commonly seen disorders in outpatient settings including ADHD, Autism, congenital heart disease, blood cancer and hematologic conditions, brain tumors, and epilepsy. Each chapter provides up-to-date information on these pediatric neurodevelopmental and medical disorders, including a review of the neuroanatomic contributions as well as an overview of the neuropsychological findings. Alongside...
Keywords	Pediatric Neuropsychology ; Neuropsychological Evaluation ; Autism Spectrum Disorder ; Pediatric Brain Tumors ; Dysembryoplastic Neuroepithelial Tumors ; Neurocognitive Late Effects ; American Psychiatric Association ; Psychological Assessment ; Pilocytic Astrocytomas ; ADHD ; Attention Deficit Hyperactivity Disorder ; Pediatric Neuropsychological Assessments ; Cultural Neuropsychology ; PVTs ; Pediatric Neuropsychological Evaluations ; Cpt Score ; Cpt Performance ; ADHD Child ; ADHD Symptom ; Asian Indian Americans ; Pediatric Epilepsy Patients ; Oral Health Issues ; Dementia Worry ; CHD Group ; Cerebellar Astrocytomas
Language	English
Size	234 p.
Edition	1
Publisher	Taylor & Francis Ltd
Document type	Book
Note	PDA Manuell_18
Format	152 x 229 x 16
ISBN	9781138193451 ; 1138193453
Database	PDA

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Article ; Online: Pediatric Neuroglial Tumors: A Review of Ependymoma and Dysembryoplastic Neuroepithelial Tumor.

Arfuso, Melissa / Kuril, Sandeepkumar / Shah, Harshal / Hanson, Derek

Pediatric neurology

2024 Volume 156, Page(s) 139–146

Language	English
Publishing date	2024-05-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639164-3
ISSN	1873-5150 ; 0887-8994
ISSN (online)	1873-5150
ISSN	0887-8994
DOI	10.1016/j.pediatrneurol.2024.04.022
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Article: Update on the Pathology of Pediatric Liver Tumors: A Pictorial Review.

Bhagat, Priyanka / Vij, Mukul / Raju, Lexmi Priya / Gowrishankar, Gowripriya / Menon, Jagadeesh / Shanmugam, Naresh / Kaliamoorthy, Ilankumaran / Rammohan, Ashwin / Rela, Mohamed

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 23

Abstract: ... hepatocellular carcinoma in teenagers. Here, we provide an up-to-date review of pediatric liver tumors. We discuss ... Liver tumors in children are uncommon and show remarkable morphologic heterogeneity. Pediatric ... in children. The most common pediatric liver tumors by age are benign hepatic infantile hemangiomas ...

Abstract	Liver tumors in children are uncommon and show remarkable morphologic heterogeneity. Pediatric tumors may arise from either the epithelial or mesenchymal component of the liver and rarely may also show both lines of differentiation. Both benign and malignant liver tumors have been reported in children. The most common pediatric liver tumors by age are benign hepatic infantile hemangiomas in neonates and infants, malignant hepatoblastoma in infants and toddlers, and malignant hepatocellular carcinoma in teenagers. Here, we provide an up-to-date review of pediatric liver tumors. We discuss the clinical presentation, imaging findings, pathology, and relevant molecular features that can help in the correct identification of these tumors, which is important in managing these children.
Language	English
Publishing date	2023-11-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13233524
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Article ; Online: An institutional review of genomic sequencing in pediatric solid tumors.

Turco, George M / Gupta, Ajay / Monteleone, Philip / Kelly, Kara M / Klein, Roger D / Wiltsie, Laura / Barth, Matthew

Pediatric blood & cancer

2023 Volume 70, Issue 6, Page(s) e30324

Abstract: ... review was performed on pediatric patients with solid tumors who were managed at Roswell Park ... to July 2021. Results were reviewed for mutations considered to be "actionable" by targeted therapy ... Background: Although tumor genomic profiling has aided the advancement of targeted genetic therapy ...

Abstract	Background: Although tumor genomic profiling has aided the advancement of targeted genetic therapy, its clinical integration remains a challenge in pediatric cancers due to lower mutation frequency and less available targeted drugs. There have been multiple novel studies examining molecular sequencing in pediatrics; however, many of these studies primarily utilized large-scale, genome-wide screening applications that limit applicable use due to the availability of testing. This study examined the institutional use of a targeted, clinically available approach to tumor genomic sequencing. Methods: A retrospective chart review was performed on pediatric patients with solid tumors who were managed at Roswell Park Comprehensive Cancer Center and underwent molecular testing of their tumor biopsy via OmniSeq from August 2016 to July 2021. Results were reviewed for mutations considered to be "actionable" by targeted therapy. Patients with actionable mutations were further examined to evaluate treatment course, receival of targeted therapy, and clinical outcomes. Results: We identified 64 pediatric patients consisting of 20 (31%) with CNS tumors and 44 (69%) with non-CNS tumors, ranging in age from 9 months to 21 years. Thirty-five total actionable mutations were identified amongst 27 patients (42%). Of these 27, 12 patients (44%) received at least 1 targeted drug against a respective actionable mutation, of which 6 patients (50%) achieved clinical benefit to therapy, including 1 complete response. Conclusions: The use of a clinically focused and readily available targeted molecular sequencing panel identified actionable mutations at a comparable rate to the large-scale, less readily available sequencing panels utilized in other studies. Half of our patients who received targeted therapy achieved a complete response or clinical benefit from therapy. Although targeted therapy has a role in pediatric cancer treatment, many newer drugs require further research on their safety and efficacy.
MeSH term(s)	Humans ; Child ; Retrospective Studies ; Precision Medicine/methods ; Neoplasms/drug therapy ; Mutation ; High-Throughput Nucleotide Sequencing/methods ; Genomics/methods ; Biomarkers, Tumor/genetics ; Molecular Targeted Therapy/methods
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2023-04-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2131448-2
ISSN	1545-5017 ; 1545-5009
ISSN (online)	1545-5017
ISSN	1545-5009
DOI	10.1002/pbc.30324
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Article ; Online: Oncolytic virotherapies for pediatric tumors.

Gross, Evan G / Hamo, Mohammad A / Estevez-Ordonez, Dagoberto / Laskay, Nicholas Mb / Atchley, Travis J / Johnston, James M / Markert, James M

Expert opinion on biological therapy

2023 Volume 23, Issue 10, Page(s) 987–1003

Abstract: ... We reviewed seven virus types that have been investigated in past or ongoing pediatric tumor clinical trials ... been made in the past 10 years regarding the clinical use of OVT. From our review, OVT has favorable ... Introduction: Many pediatric patients with malignant tumors continue to suffer poor outcomes ...

Abstract	Introduction: Many pediatric patients with malignant tumors continue to suffer poor outcomes. The current standard of care includes maximum safe surgical resection followed by chemotherapy and radiation which may be associated with considerable long-term morbidity. The emergence of oncolytic virotherapy (OVT) may provide an alternative or adjuvant treatment for pediatric oncology patients. Areas covered: We reviewed seven virus types that have been investigated in past or ongoing pediatric tumor clinical trials: adenovirus (AdV-tk, Celyvir, DNX-2401, VCN-01, Ad-TD-nsIL-12), herpes simplex virus (G207, HSV-1716), vaccinia (JX-594), reovirus (pelareorep), poliovirus (PVSRIPO), measles virus (MV-NIS), and Senecavirus A (SVV-001). For each virus, we discuss the mechanism of tumor-specific replication and cytotoxicity as well as key findings of preclinical and clinical studies. Expert opinion: Substantial progress has been made in the past 10 years regarding the clinical use of OVT. From our review, OVT has favorable safety profiles compared to chemotherapy and radiation treatment. However, the antitumor effects of OVT remain variable depending on tumor type and viral agent used. Although the widespread adoption of OVT faces many challenges, we are optimistic that OVT will play an important role alongside standard chemotherapy and radiotherapy for the treatment of malignant pediatric solid tumors in the future.
MeSH term(s)	Humans ; Child ; Oncolytic Virotherapy ; Oncolytic Viruses/genetics ; Neoplasms/therapy ; Simplexvirus/genetics ; Vaccinia virus ; Genetic Therapy
Language	English
Publishing date	2023-10-05
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2052501-1
ISSN	1744-7682 ; 1471-2598
ISSN (online)	1744-7682
ISSN	1471-2598
DOI	10.1080/14712598.2023.2245326
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