Article ; Online: Risk factors for seasonal influenza virus detection in stools of patients consulting in general practice for acute respiratory infections in France, 2014-2016.
Influenza and other respiratory viruses
2019 Volume 13, Issue 4, Page(s) 398–406
Abstract: ... respiratory infection (ARI) patients were enrolled by general practitioners (GP) during two winter seasons (2014-2016 ... viral RNA in the stools of patients with laboratory-confirmed influenza infection.: Methods: Acute ... Background: Previous studies reported detection of influenza RNA in stools of patients ...
| Abstract | Background: Previous studies reported detection of influenza RNA in stools of patients with seasonal influenza infection. While this detection may have a clinical significance, other factors may influence the stool positivity for influenza viruses. Objectives: The objective of this study was to investigate demographical, clinical, and microbiological factors which could favor the presence of influenza viral RNA in the stools of patients with laboratory-confirmed influenza infection. Methods: Acute respiratory infection (ARI) patients were enrolled by general practitioners (GP) during two winter seasons (2014-2016). Nasopharyngeal swabs, stool specimens, and clinical data were collected. Samples were tested for 12 respiratory pathogen groups (nasopharyngeal and stool specimens) and for 12 enteric pathogens (stool specimens). Results: Among the 331 patients with ARI enrolled by GP, 114 (34.4%) presented influenza infection. Influenza RNA was detected in stool samples of 21% (24/114) of the 114 stool specimens analyzed. Hospitalization (adjusted odds ratio (aOR) = 7.8 (95% confidence interval (CI)) [1.7-33.7], P = .02), age between 45 and 64 years (aOR = 4.8 [1.7-14.5], P = .01), consumption of raw shellfish and/or mollusks (aOR = 16.7 [3.6-90.9], P = .00), and use of antibiotics (aOR = 6.4 [2.1-19.8], P = .006) or antiviral treatment (aOR = 7.4 [1.9-29], P = .01) were significantly associated with an increased odds of the detection of influenza RNA in stools. Among the 24 stool samples subjected to viral isolation, no one showed virus growth. Conclusions: These findings will be useful to studies investigating the dissemination route of influenza viruses to gastrointestinal tract. |
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| MeSH term(s) | Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Cross-Sectional Studies ; Feces/virology ; Female ; France/epidemiology ; General Practice ; Humans ; Infant ; Infant, Newborn ; Influenza, Human/epidemiology ; Male ; Middle Aged ; Nasopharynx/virology ; Orthomyxoviridae/genetics ; Orthomyxoviridae/isolation & purification ; Prospective Studies ; RNA, Viral/analysis ; Respiratory Tract Infections/epidemiology ; Respiratory Tract Infections/virology ; Risk Factors ; Young Adult | |||||
| Chemical Substances | RNA, Viral | |||||
| Keywords | covid19 | |||||
| Language | English | |||||
| Publishing date | 2019-05-10 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Observational Study | |||||
| ZDB-ID | 2274538-5 | |||||
| ISSN | 1750-2659 ; 1750-2640 | |||||
| ISSN (online) | 1750-2659 | |||||
| ISSN | 1750-2640 | |||||
| DOI | 10.1111/irv.12523 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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