Article ; Online: Clinical course of severe COVID19 treated with tocilizumab and antivirals post-allogeneic stem cell transplant with extensive chronic GVHD.
Transplant infectious disease : an official journal of the Transplantation Society
2021 Volume 23, Issue 4, Page(s) e13576
Abstract: ... The patient was treated with tocilizumab, and a combination of lopinavir/ritonavir, ribavirin, interferon-β1b ... Recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are ... report, to our knowledge, of its use and benefit in a post HSCT recipient. ...
| Abstract | Recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are an immunocompromised group who are likely to develop severe complications and mortality because of coronavirus disease 2019 (COVID-19). We report here a 61-year-old male patient of primary myelofibrosis who underwent an allo-HSCT 6 years earlier, had chronic graft-versus-host disease (cGVHD) involving the liver, lung, eyes, and skin, (with recurrent episodes of pulmonary infections) who developed severe COVID-19. The patient was treated with tocilizumab, and a combination of lopinavir/ritonavir, ribavirin, interferon-β1b. He was discharged after 31 days with full recovery. Tocilizumab, a humanized monoclonal antibody against IL6, has been shown to benefit respiratory manifestations in severe COVID19. However, this is first report, to our knowledge, of its use and benefit in a post HSCT recipient. |
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| MeSH term(s) | Antibodies, Monoclonal, Humanized ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; Graft vs Host Disease/drug therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Male ; Middle Aged ; SARS-CoV-2 ; Stem Cell Transplantation/adverse effects | |||||
| Chemical Substances | Antibodies, Monoclonal, Humanized ; Antiviral Agents ; tocilizumab (I031V2H011) | |||||
| Language | English | |||||
| Publishing date | 2021-02-18 | |||||
| Publishing country | Denmark | |||||
| Document type | Case Reports | |||||
| ZDB-ID | 1476094-0 | |||||
| ISSN | 1399-3062 ; 1398-2273 | |||||
| ISSN (online) | 1399-3062 | |||||
| ISSN | 1398-2273 | |||||
| DOI | 10.1111/tid.13576 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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