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  1. Article ; Online: Acute leukemia and SARS-CoV-2 infection: clinical characteristics and risk factors for mortality.

    Mitrovic, Mirjana / Pantic, Nikola / Sabljic, Nikica / Vucic, Miodrag / Bukumiric, Zoran / Virijevic, Marijana / Pravdic, Zlatko / Rajic, Jovan / Todorovic-Balint, Milena / Vidovic, Ana / Suvajdzic-Vukovic, Nada

    Leukemia & lymphoma

    2021  Volume 62, Issue 14, Page(s) 3516–3520

    Abstract: Patients with acute leukemia (AL) have a high mortality rate from coronavirus disease 2019 (COVID ... prolonged PT, higher ISTH DIC score, CRP and LDH. Moreover, careful risk-benefit assessment regarding ... COVID-19 were included in our study. The mortality rate was 17/51 (29.4%). In all cases, death was ...

    Abstract Patients with acute leukemia (AL) have a high mortality rate from coronavirus disease 2019 (COVID-19). However, studies including patients with AL and COVID-19 are few. Fifty-one patients with AL and COVID-19 were included in our study. The mortality rate was 17/51 (29.4%). In all cases, death was associated with COVID-19 pneumonia. The major driver of outcome was the disease status (worse outcome was observed in newly diagnosed (OR, 6.00; 95% CI, 1.133 - 15.188) and patients with bone marrow aplasia (OR 4.148 [95% CI 1.133 - 15.188])). Higher mortality rate was associated with lower platelet count, prolonged PT, higher ISTH DIC score, CRP and LDH. Moreover, careful risk-benefit assessment regarding the continuation of anticancer therapy is required in patients receiving nonintensive and supportive therapy. Considering the high frequency of intrahospital viral transmission (50.98%), isolation of AL patients in single rooms, and permanent symptom monitoring and testing should be prioritized.
    MeSH term(s) COVID-19 ; Humans ; Leukemia/diagnosis ; Leukemia/epidemiology ; Leukemia/therapy ; Risk Factors ; SARS-CoV-2
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Letter
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2021.1964026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Characteristics, clinical outcomes, and risk factors of SARS-COV-2 infection in adult acute myeloid leukemia patients: experience of the PETHEMA group.

    Palanques-Pastor, Tomás / Megías-Vericat, Juan Eduardo / Martínez, Pilar / López Lorenzo, José Luis / Cornago Navascués, Javier / Rodriguez Macias, Gabriela / Cano, Isabel / Arnan Sangerman, Montserrat / Vidriales Vicente, María Belén / Algarra Algarra, Jesús Lorenzo / Foncillas, María Ángeles / Herrera, Pilar / Botella Prieto, Carmen / Vives, Susana / Figuera Álvarez, Ángela / Cuevas Palomares, Laida / Sobas, Marta / Contento Gonzalo, Alejandro / Cuello García, Rebeca /
    Amutio Diez, María Elena / De Miguel Llorente, Dunia / Navas Elorza, Begoña / Bergua Burgues, Juan Miguel / Bernal Del Castillo, Teresa / Mateos Rodríguez, María Carmen / de Cabo López, Erik / Franco Villegas, Ana Carolina / García Boyero, Raimundo / Escolano Escobar, Cristian / Seri Merino, Cristina / Cervero, Carlos / Roldán Pérez, Alicia / Hermosín Ramos, Lourdes / Cervera Calvo, Marta / Olave, María Telesa / Villafuerte Gutiérrez, Paola / de Laiglesiai, Almudena / Serrano, Josefina / Najera Irazu, María Josefa / Piñana, José Luis / Sanz, Miguel Ángel / Martínez-López, Joaquín / Montesinos, Pau

    Leukemia & lymphoma

    2021  Volume 62, Issue 12, Page(s) 2928–2938

    Abstract: ... treatment for SARS-CoV-2. The mortality rate was 43.5% and was correlated with age, gender, active leukemia ... and mortality in hematological malignancies, but evidence in acute myeloid leukemia (AML) is scarce ... CoV-2 first wave, our findings suggested an increased mortality in AML in a short period. SARS-CoV-2 ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces higher morbidity and mortality in hematological malignancies, but evidence in acute myeloid leukemia (AML) is scarce. A multicenter observational study was conducted to determine the clinical outcomes and assess the impact of therapeutic approaches in adult AML patients with SARS-CoV-2 infection in the first wave (March-May 2020). Overall, 108 patients were included: 51.9% with active leukemia and 70.4% under therapeutic schedules for AML. Signs and symptoms of SARS-CoV-2 were present in 96.3% of patients and 82.4% received specific treatment for SARS-CoV-2. The mortality rate was 43.5% and was correlated with age, gender, active leukemia, dyspnea, severe SARS-CoV-2, intensive care measures, neutrophil count, and D-dimer levels. A protective effect was found with azithromycin, lopinavir/ritonavir, and normal liver enzyme levels. During the SARS-CoV-2 first wave, our findings suggested an increased mortality in AML in a short period. SARS-CoV-2 management could be guided by risk factors in AML patients.
    MeSH term(s) Adult ; COVID-19 ; Humans ; Leukemia, Myeloid, Acute/epidemiology ; Leukemia, Myeloid, Acute/therapy ; Lopinavir ; Risk Factors ; SARS-CoV-2
    Chemical Substances Lopinavir (2494G1JF75)
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2021.1948031
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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