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  1. Article ; Online: Erratum to: Nebulized Magnesium Sulfate in Acute Bronchiolitis: A Randomized Controlled Trial.

    Modaresi, Mohammad Reza / Faghihinia, Jamal / Kelishadi, Roya / Reisi, Mohsen / Mirlohi, Shahrokh / Pajhang, Farhad / Sadeghian, Majid

    Indian journal of pediatrics

    2016  Volume 83, Issue 5, Page(s) 487

    Abstract: ... the efficacy of magnesium sulfate in the treatment of acute bronchiolitis. The authors apologize ... The efficacy of nebulized salbutamol, magnesium sulfate and salbutamol/magnesium sulfate combination ... in moderate bronchiolitis. Eur J Pediatr 2014;173: 1157-1160" as the first in literature to assess ...

    Abstract In the original article, the authors failed to cite the study by Kose M et al. entitled "The efficacy of nebulized salbutamol, magnesium sulfate and salbutamol/magnesium sulfate combination in moderate bronchiolitis. Eur J Pediatr 2014;173: 1157-1160" as the first in literature to assess the efficacy of magnesium sulfate in the treatment of acute bronchiolitis. The authors apologize for this unintentional omission.
    Language English
    Publishing date 2016-05
    Publishing country India
    Document type Published Erratum
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-016-2069-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nebulized Magnesium Sulfate in Acute Bronchiolitis: A Randomized Controlled Trial.

    Modaresi, Mohammad Reza / Faghihinia, Jamal / Kelishadi, Roya / Reisi, Mohsen / Mirlohi, Shahrokh / Pajhang, Farhad / Sadeghian, Majid

    Indian journal of pediatrics

    2015  Volume 82, Issue 9, Page(s) 794–798

    Abstract: ... hospitalized with acute bronchiolitis.: Methods: This three-center double masked randomized clinical trial ... Objective: To assess the efficacy of nebulized magnesium sulfate as a bronchodilator in infants ... the first group was treated with nebulized magnesium sulfate (40 mg/kg) and nebulized epinephrine (0.1 ml/kg ...

    Abstract Objective: To assess the efficacy of nebulized magnesium sulfate as a bronchodilator in infants hospitalized with acute bronchiolitis.
    Methods: This three-center double masked randomized clinical trial comprised 120 children with moderate to severe bronchiolitis. They were randomly assigned into two groups: the first group was treated with nebulized magnesium sulfate (40 mg/kg) and nebulized epinephrine (0.1 ml/kg) and the second group (control) was treated with nebulized epinephrine (0.1 ml/kg). The primary outcome was the length of hospital stay. The use of oxygen, temperature, oxygen saturation (SPO2), pulse rate (PR), respiratory rate (RR) and respiratory distress assessment instrument (RDAI) score were measured in the beginning of the study and during hospitalization.
    Results: The mean (SD) age of 120 infants was 5.1(± 2.6) mo and 60% were boys. The length of hospital stay was not different between the two groups (P > 0.01). Use of oxygen supplementation, SPO2 and vital signs were similar in the two groups. Improvement in RDAI score was significantly better in infants treated with nebulized magnesium sulfate than in the other group (P 0.01).
    Conclusions: Thus, in infants with acute bronchiolitis, the effect of nebulized magnesium sulfate is comparable to nebulized epinephrine. However nebulized magnesium sulfate can improve the clinical score so it may have additive effect to reduce symptoms during hospitalization.
    MeSH term(s) Acute Disease ; Bronchitis/drug therapy ; Bronchodilator Agents/administration & dosage ; Double-Blind Method ; Epinephrine/administration & dosage ; Female ; Humans ; Infant ; Magnesium Sulfate/administration & dosage ; Male ; Nebulizers and Vaporizers
    Chemical Substances Bronchodilator Agents ; Magnesium Sulfate (7487-88-9) ; Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2015-09
    Publishing country India
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-015-1729-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nebulized Magnesium Sulphate in Bronchiolitis: A Randomized Controlled Trial.

    Debbarma, Roma / Khera, Daisy / Singh, Surjit / Toteja, Nisha / Choudhary, Bharat / Singh, Kuldeep

    Indian journal of pediatrics

    2021  Volume 88, Issue 11, Page(s) 1080–1085

    Abstract: ... This was an open labeled randomized controlled trial comprising 60 children with moderate to severe ... Objective: To evaluate the efficacy and safety of nebulized magnesium sulphate as a bronchodilator ... Nebulized magnesium sulphate is not superior to standard therapy in children with moderate to severe ...

    Abstract Objective: To evaluate the efficacy and safety of nebulized magnesium sulphate as a bronchodilator in young children aged 1-24 mo with moderate to severe bronchiolitis in comparison to standard therapy.
    Methods: This was an open labeled randomized controlled trial comprising 60 children with moderate to severe bronchiolitis which was randomly assigned to 2 groups. Intervention group received nebulization with 3 mL of 3.2% magnesium sulphate (MgSO
    Results: The mean age of children allocated in the control group was 7.4 ± 5.1 mo and 7.7 ± 4.5 mo in the intervention group. There was no significant difference with respect to improvement of BSS or reduced length of hospitalization in both the groups (p > 0.05). BSS monitored sequentially after enrollment at 1, 2, 4, 8, 12, 16, and 24 h did not show statistically significant differences between the groups. Mean length of hospital stay was 2.89 ± 2.25 d in treatment group and 2.96 ± 1.86 d in control group (p = 0.902). No adverse events were observed in both the groups.
    Conclusion: Nebulized magnesium sulphate is not superior to standard therapy in children with moderate to severe bronchiolitis.
    Clinical trial registration number: CTRI/2018/06/014400.
    MeSH term(s) Acute Disease ; Bronchiolitis/drug therapy ; Bronchodilator Agents/therapeutic use ; Child ; Child, Preschool ; Humans ; Infant ; Magnesium Sulfate ; Nebulizers and Vaporizers ; Treatment Outcome
    Chemical Substances Bronchodilator Agents ; Magnesium Sulfate (7487-88-9)
    Language English
    Publishing date 2021-03-27
    Publishing country India
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-021-03695-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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