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  1. Article: Prevalence of Venous Thromboembolism in Critically Ill COVID-19 Patients: Systematic Review and Meta-Analysis.

    Mohamed, Mouhand F H / Al-Shokri, Shaikha D / Shunnar, Khaled M / Mohamed, Sara F / Najim, Mostafa S / Ibrahim, Shahd I / Elewa, Hazem / Abdalla, Lina O / El-Bardissy, Ahmed / Elshafei, Mohamed Nabil / Abubeker, Ibrahim Y / Danjuma, Mohammed / Dousa, Khalid M / Yassin, Mohamed A

    Frontiers in cardiovascular medicine

    2021  Volume 7, Page(s) 598846

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-01-08
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2020.598846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prevalence of Venous Thromboembolism in Critically-ill COVID-19 Patients: Systematic Review and Meta-analysis

    Mohamed, Mouhand F.H. / Al-Shokri, Shaikha D. / Shunnar, Khaled M. / Mohamed, Sara F. / Najim, Mostafa S. / Ibrahim, Shahd I. / Elewa, Hazem / Dousa, Khalid M. / Abdalla, Lina O. / El-Bardissy, Ahmed / Elshafei, Mohamed Nabil / Abubeker, Ibrahim Y. / Danjuma, Mohammed / Yassin, Mohamed A

    Abstract: ... for studies exploring the prevalence of VTE in critically ill COVID-19 patients till 22/07/2020. We pooled ... in coronavirus disease 2019 (COVID-19) patients, especially in those who are critically ill. Available studies ... COVID-19 patients. Almost 50% of patients had VTE detected by systematic screening. Higher ...

    Abstract Background: Recent studies revealed a high prevalence of venous thromboembolism (VTE) events in coronavirus disease 2019 (COVID-19) patients, especially in those who are critically ill. Available studies report varying prevalence rates. Hence, the exact prevalence remains uncertain. Moreover, there is an ongoing debate regarding the appropriate dosage of thromboprophylaxis. Methods: We performed a systematic review and proportion meta-analysis following PRISMA guidelines. We searched PubMed and EMBASE for studies exploring the prevalence of VTE in critically ill COVID-19 patients till 22/07/2020. We pooled the proportion of VTE. Additionally, in a subgroup analysis, we pooled VTE events detected by systematic screening. Finally, we compared the odds of VTE in patients on prophylactic compared to therapeutic anticoagulation. Results: The review comprised of 24 studies and over 2500 patients. The pooled proportion of VTE prevalence was 0.31 (95% CI 0.24, 0.39 I2 94%), of VTE utilizing systematic screening was 0.48 (95% CI 0.33, 0.63 I2 91%), of deep-venous-thrombosis was 0.23 (95% CI 0.14, 0.32 I2 96%), of pulmonary embolism was 0.14 (95% CI 0.09, 0.20 I2 90%). In a subgroup of studies, utilizing systematic screening, VTE risk increased significantly with prophylactic, compared to therapeutic anticoagulation (OR 5.45; 95% CI 1.90, 15.57 I2 0%). Discussion: Our review revealed a high prevalence of VTE in critically ill COVID-19 patients. Almost 50% of patients had VTE detected by systematic screening. Higher thromboprophylaxis dosages seem to reduce VTE burden in this patient's cohort compared to standard prophylactic anticoagulation; ongoing randomized controlled trials will further confirm this.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    Note WHO #Covidence: #20175745
    DOI 10.1101/2020.08.24.20175745
    Database COVID19

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  3. Article ; Online: Prevalence of Venous Thromboembolism in Critically-ill COVID-19 Patients: Systematic Review and Meta-analysis

    Mohamed, Mouhand F.H. / Al-Shokri, Shaikha D. / Shunnar, Khaled M. / Mohamed, Sara F. / Najim, Mostafa S. / Ibrahim, Shahd I. / Elewa, Hazem / Dousa, Khalid M. / Abdalla, Lina O. / El-Bardissy, Ahmed / Elshafei, Mohamed Nabil / Abubeker, Ibrahim Y. / Danjuma, Mohammed / Yassin, Mohamed A

    medRxiv

    Abstract: ... for studies exploring the prevalence of VTE in critically ill COVID-19 patients till 22/07/2020. We pooled ... in coronavirus disease 2019 (COVID-19) patients, especially in those who are critically ill. Available studies ... COVID-19 patients. Almost 50% of patients had VTE detected by systematic screening. Higher ...

    Abstract Background: Recent studies revealed a high prevalence of venous thromboembolism (VTE) events in coronavirus disease 2019 (COVID-19) patients, especially in those who are critically ill. Available studies report varying prevalence rates. Hence, the exact prevalence remains uncertain. Moreover, there is an ongoing debate regarding the appropriate dosage of thromboprophylaxis. Methods: We performed a systematic review and proportion meta-analysis following PRISMA guidelines. We searched PubMed and EMBASE for studies exploring the prevalence of VTE in critically ill COVID-19 patients till 22/07/2020. We pooled the proportion of VTE. Additionally, in a subgroup analysis, we pooled VTE events detected by systematic screening. Finally, we compared the odds of VTE in patients on prophylactic compared to therapeutic anticoagulation. Results: The review comprised of 24 studies and over 2500 patients. The pooled proportion of VTE prevalence was 0.31 (95% CI 0.24, 0.39 I2 94%), of VTE utilizing systematic screening was 0.48 (95% CI 0.33, 0.63 I2 91%), of deep-venous-thrombosis was 0.23 (95% CI 0.14, 0.32 I2 96%), of pulmonary embolism was 0.14 (95% CI 0.09, 0.20 I2 90%). In a subgroup of studies, utilizing systematic screening, VTE risk increased significantly with prophylactic, compared to therapeutic anticoagulation (OR 5.45; 95% CI 1.90, 15.57 I2 0%). Discussion: Our review revealed a high prevalence of VTE in critically ill COVID-19 patients. Almost 50% of patients had VTE detected by systematic screening. Higher thromboprophylaxis dosages seem to reduce VTE burden in this patient9s cohort compared to standard prophylactic anticoagulation; ongoing randomized controlled trials will further confirm this.
    Keywords covid19
    Language English
    Publishing date 2020-08-29
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.08.24.20175745
    Database COVID19

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  4. Article: Prevalence of Thromboembolic Events, Including Venous Thromboembolism and Arterial Thrombosis, in Patients with COVID-19: A Systematic Review with Meta-Analysis.

    Bagheri, Babak / Alipour, Abbas / Yousefi, Mojtaba / Jalalian, Rozita / Moghimi, Minoo / Mohammadi, Mahsa / Hassanpour, Negar / Iranian, Mohammadreza

    The journal of Tehran Heart Center

    2023  Volume 18, Issue 3, Page(s) 154–169

    Abstract: ... the prevalence of thromboembolic events in patients with COVID-19.: Methods: This study is a systematic review ... with meta-analysis that investigated thromboembolic events in patients with COVID-19 from the start of the pandemic ... especially in elderly and critically ill patients admitted to the ICU. Therefore, more strategies are needed ...

    Abstract Background: Many studies have evaluated thromboembolic events in COVID-19 patients, and most of them have reported a high estimation of the prevalence of such events. The present study sought to evaluate the prevalence of thromboembolic events in patients with COVID-19.
    Methods: This study is a systematic review with meta-analysis that investigated thromboembolic events in patients with COVID-19 from the start of the pandemic to August 31, 2021. The 4 main databases for collecting articles were Medline, Scopus, Google Scholar, and Web of Science. Deep vein thrombosis, pulmonary embolism, arterial thrombosis, and the overall rate of thromboembolic events were considered primary outcomes.
    Results: In a total of 63 studies (104 920 patients with COVID-19), the overall thrombosis rate was 21% (95% CI, 18% to 25%), the rate of deep vein thrombosis was 20% (95% Cl, 16% to 25%), the rate of pulmonary embolism was 8% (95% Cl, 6% to 10%), and the rate of arterial thrombosis was 5% (95% Cl, 3% to 7%). The prevalence of all primary outcomes in critically ill patients admitted to the intensive care unit (ICU) was significantly higher (P<0.05). In older patients, the prevalence of overall thrombosis, pulmonary embolism, or deep vein thrombosis was significantly higher (P<0.05).
    Conclusion: This study showed that COVID-19 increases the risk of thromboembolic events, especially in elderly and critically ill patients admitted to the ICU. Therefore, more strategies are needed to prevent thromboembolic events in patients with COVID-19, especially in ICU-admitted and elderly patients.
    Language English
    Publishing date 2023-12-21
    Publishing country Iran
    Document type Journal Article ; Review
    ZDB-ID 2476998-8
    ISSN 2008-2371 ; 1735-5370 ; 1735-8620
    ISSN (online) 2008-2371
    ISSN 1735-5370 ; 1735-8620
    DOI 10.18502/jthc.v18i3.14110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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