Article ; Online: Diagnosed and Undiagnosed COVID-19 in US Emergency Department Health Care Personnel: A Cross-sectional Analysis.
2020 Volume 78, Issue 1, Page(s) 27–34
Abstract: ... reverse transcriptase-polymerase chain reaction result among health care personnel without prior diagnosis.: Results: Diagnosed COVID-19 ... health care personnel without previously diagnosed COVID-19, 29 (1.8%) had evidence of current or past SARS ... personnel before July 2020.: Methods: This was a cross-sectional analysis of ED health care personnel ...
| Abstract | Study objective: We determine the percentage of diagnosed and undiagnosed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among a sample of US emergency department (ED) health care personnel before July 2020. Methods: This was a cross-sectional analysis of ED health care personnel in 20 geographically diverse university-affiliated EDs from May 13, to July 8, 2020, including case counts of prior laboratory-confirmed coronavirus disease 2019 (COVID-19) diagnoses among all ED health care personnel, and then point-in-time serology (with confirmatory testing) and reverse transcriptase-polymerase chain reaction testing in a sample of volunteers without a previous COVID-19 diagnosis. Health care staff were categorized as clinical (physicians, advanced practice providers, and nurses) and nonclinical (clerks, social workers, and case managers). Previously undiagnosed infection was based on positive SARS-CoV-2 serology or reverse transcriptase-polymerase chain reaction result among health care personnel without prior diagnosis. Results: Diagnosed COVID-19 occurred in 2.8% of health care personnel (193/6,788), and the prevalence was similar for nonclinical and clinical staff (3.8% versus 2.7%; odds ratio 1.5; 95% confidence interval 0.7 to 3.2). Among 1,606 health care personnel without previously diagnosed COVID-19, 29 (1.8%) had evidence of current or past SARS-CoV-2 infection. Most (62%; 18/29) who were seropositive did not think they had been infected, 76% (19/25) recalled COVID-19-compatible symptoms, and 89% (17/19) continued to work while symptomatic. Accounting for both diagnosed and undiagnosed infections, 4.6% (95% confidence interval 2.8% to 7.5%) of ED health care personnel were estimated to have been infected with SARS-CoV-2, with 38% of those infections undiagnosed. Conclusion: In late spring and early summer 2020, the estimated prevalence of severe acute respiratory syndrome coronavirus 2 infection was 4.6%, and greater than one third of infections were undiagnosed. Undiagnosed SARS-CoV-2 infection may pose substantial risk for transmission to other staff and patients. |
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| MeSH term(s) | Adult ; COVID-19/diagnosis ; COVID-19/epidemiology ; Cross-Sectional Studies ; Emergency Service, Hospital/statistics & numerical data ; Female ; Health Personnel/statistics & numerical data ; Hospitals, University/statistics & numerical data ; Humans ; Male ; Middle Aged ; Prevalence ; SARS-CoV-2 ; United States/epidemiology | |||||
| Language | English | |||||
| Publishing date | 2020-12-17 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Multicenter Study | |||||
| ZDB-ID | 603080-4 | |||||
| ISSN | 1097-6760 ; 0196-0644 | |||||
| ISSN (online) | 1097-6760 | |||||
| ISSN | 0196-0644 | |||||
| DOI | 10.1016/j.annemergmed.2020.12.007 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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