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  1. Article ; Online: Stem Cells and Therapy: Emerging Approaches.

    Monti, Manuela

    European journal of histochemistry : EJH

    2020  Volume 64, Issue 3

    Abstract: The ten chapters of this volume exploit the potentials of stem cells biology ... in translational medicine in a very clear way also thanks to nice color illustrations together with tricks and suggestions ...

    Abstract The ten chapters of this volume exploit the potentials of stem cells biology in translational medicine in a very clear way also thanks to nice color illustrations together with tricks and suggestions useful to get reproducible results...
    Keywords covid19
    Language English
    Publishing date 2020-09-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1109511-8
    ISSN 2038-8306 ; 0391-7258 ; 1121-4201 ; 1121-760X
    ISSN (online) 2038-8306
    ISSN 0391-7258 ; 1121-4201 ; 1121-760X
    DOI 10.4081/ejh.2020.3178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Stem cell therapy: a novel approach against emerging and re-emerging viral infections with special reference to SARS-CoV-2.

    Khandelwal, Vishal / Sharma, Tarubala / Gupta, Saurabh / Singh, Shoorvir / Sharma, Manish Kumar / Parashar, Deepak / Kashyap, Vivek K

    Molecular biology reports

    2022  Volume 50, Issue 3, Page(s) 2663–2683

    Abstract: ... therapy is considered a novel approach to regenerate damaged lungs and reduce inflammation. Stem cell ... considerations for the implications of stem cell therapy and presents a necessary approach for treating virally ... proliferation rate, which makes them an attractive tool for cellular therapies and to treat various inflammatory ...

    Abstract The past several decades have witnessed the emergence and re-emergence of many infectious viral agents, flaviviruses, influenza, filoviruses, alphaviruses, and coronaviruses since the advent of human deficiency virus (HIV). Some of them even become serious threats to public health and have raised major global health concerns. Several different medicinal compounds such as anti-viral, anti-malarial, and anti-inflammatory agents, are under investigation for the treatment of these viral diseases. These therapies are effective improving recovery rates and overall survival of patients but are unable to heal lung damage caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, there is a critical need to identify effective treatments to combat this unmet clinical need. Due to its antioxidant and immunomodulatory properties, stem cell therapy is considered a novel approach to regenerate damaged lungs and reduce inflammation. Stem cell therapy uses a heterogeneous subset of regenerative cells that can be harvested from various adult tissue types and is gaining popularity due to its prodigious regenerative potential as well as immunomodulatory and anti-inflammatory properties. These cells retain expression of cluster of differentiation markers (CD markers), interferon-stimulated gene (ISG), reduce expression of pro-inflammatory cytokines and, show a rapid proliferation rate, which makes them an attractive tool for cellular therapies and to treat various inflammatory and viral-induced injuries. By examining various clinical studies, this review demonstrates positive considerations for the implications of stem cell therapy and presents a necessary approach for treating virally induced infections in patients.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19/therapy ; Interferons ; Lung ; Stem Cell Transplantation
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2022-12-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07957-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Stem cell therapy: a novel approach against emerging and re-emerging viral infections with special reference to SARS-CoV-2

    Khandelwal, Vishal / Sharma, Tarubala / Gupta, Saurabh / Singh, Shoorvir / Sharma, Manish Kumar / Parashar, Deepak / Kashyap, Vivek K.

    Mol Biol Rep. 2023 Mar., v. 50, no. 3 p.2663-2683

    2023  

    Abstract: ... therapy is considered a novel approach to regenerate damaged lungs and reduce inflammation. Stem cell ... considerations for the implications of stem cell therapy and presents a necessary approach for treating virally ... proliferation rate, which makes them an attractive tool for cellular therapies and to treat various inflammatory ...

    Abstract The past several decades have witnessed the emergence and re-emergence of many infectious viral agents, flaviviruses, influenza, filoviruses, alphaviruses, and coronaviruses since the advent of human deficiency virus (HIV). Some of them even become serious threats to public health and have raised major global health concerns. Several different medicinal compounds such as anti-viral, anti-malarial, and anti-inflammatory agents, are under investigation for the treatment of these viral diseases. These therapies are effective improving recovery rates and overall survival of patients but are unable to heal lung damage caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, there is a critical need to identify effective treatments to combat this unmet clinical need. Due to its antioxidant and immunomodulatory properties, stem cell therapy is considered a novel approach to regenerate damaged lungs and reduce inflammation. Stem cell therapy uses a heterogeneous subset of regenerative cells that can be harvested from various adult tissue types and is gaining popularity due to its prodigious regenerative potential as well as immunomodulatory and anti-inflammatory properties. These cells retain expression of cluster of differentiation markers (CD markers), interferon-stimulated gene (ISG), reduce expression of pro-inflammatory cytokines and, show a rapid proliferation rate, which makes them an attractive tool for cellular therapies and to treat various inflammatory and viral-induced injuries. By examining various clinical studies, this review demonstrates positive considerations for the implications of stem cell therapy and presents a necessary approach for treating virally induced infections in patients.
    Keywords Alphavirus ; Filoviridae ; Flaviviridae ; Severe acute respiratory syndrome coronavirus 2 ; adults ; antimalarials ; antioxidants ; cytokines ; genes ; humans ; inflammation ; influenza ; lungs ; public health ; stem cells ; therapeutics ; viruses
    Language English
    Dates of publication 2023-03
    Size p. 2663-2683.
    Publishing place Springer Netherlands
    Document type Article ; Online
    Note Review
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-022-07957-2
    Database NAL-Catalogue (AGRICOLA)

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  4. Article: Progress in Glioma Stem Cell Research.

    Ramar, Vanajothi / Guo, Shanchun / Hudson, BreAnna / Liu, Mingli

    Cancers

    2023  Volume 16, Issue 1

    Abstract: ... therapeutic approaches encompass immunotherapy, including checkpoint inhibitors, and targeted treatments ... glioma stem cells (GSCs), drug efflux pumps, and DNA damage repair mechanisms, persist beyond complete ... approaches to GSC targets and currently used inhibitors, as well as their mode of action on GSC targets. ...

    Abstract Glioblastoma multiforme (GBM) represents a diverse spectrum of primary tumors notorious for their resistance to established therapeutic modalities. Despite aggressive interventions like surgery, radiation, and chemotherapy, these tumors, due to factors such as the blood-brain barrier, tumor heterogeneity, glioma stem cells (GSCs), drug efflux pumps, and DNA damage repair mechanisms, persist beyond complete isolation, resulting in dismal outcomes for glioma patients. Presently, the standard initial approach comprises surgical excision followed by concurrent chemotherapy, where temozolomide (TMZ) serves as the foremost option in managing GBM patients. Subsequent adjuvant chemotherapy follows this regimen. Emerging therapeutic approaches encompass immunotherapy, including checkpoint inhibitors, and targeted treatments, such as bevacizumab, aiming to exploit vulnerabilities within GBM cells. Nevertheless, there exists a pressing imperative to devise innovative strategies for both diagnosing and treating GBM. This review emphasizes the current knowledge of GSC biology, molecular mechanisms, and associations with various signals and/or pathways, such as the epidermal growth factor receptor, PI3K/AKT/mTOR, HGFR/c-MET, NF-κB, Wnt, Notch, and STAT3 pathways. Metabolic reprogramming in GSCs has also been reported with the prominent activation of the glycolytic pathway, comprising aldehyde dehydrogenase family genes. We also discuss potential therapeutic approaches to GSC targets and currently used inhibitors, as well as their mode of action on GSC targets.
    Language English
    Publishing date 2023-12-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16010102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Stem cell therapy for acute myocardial infarction: Mesenchymal Stem Cells and induced Pluripotent Stem Cells.

    Clavellina, Diana / Balkan, Wayne / Hare, Joshua M

    Expert opinion on biological therapy

    2023  Volume 23, Issue 10, Page(s) 951–967

    Abstract: ... such as pluripotent stem cells and conducting well-designed trials will harness the full potential of cell-based therapy in AMI ... of the advances, limitations and prospects for cell-based therapy in AMI.: Expert opinion: MSCs continue ... tissue after AMI are not addressed by current pharmacologic interventions. Mesenchymal stem/stromal cells ...

    Abstract Introduction: Acute myocardial infarction (AMI) remains a leading cause of death in the United States. The limited capacity of cardiomyocytes to regenerate and the restricted contractility of scar tissue after AMI are not addressed by current pharmacologic interventions. Mesenchymal stem/stromal cells (MSCs) have emerged as a promising therapeutic approach due to their low antigenicity, ease of harvesting, and efficacy and safety in preclinical and clinical studies, despite their low survival and engraftment rates. Other stem cell types, such as induced pluripotent stem cells (iPSCs) also show promise, and optimizing cardiac repair requires integrating emerging technologies and strategies.
    Areas covered: This review offers insights into advancing cell-based therapies for AMI, emphasizing meticulously planned trials with a standardized definition of AMI, for a bench-to-bedside approach. We critically evaluate fundamental studies and clinical trials to provide a comprehensive overview of the advances, limitations and prospects for cell-based therapy in AMI.
    Expert opinion: MSCs continue to show potential promise for treating AMI and its sequelae, but addressing their low survival and engraftment rates is crucial for clinical success. Integrating emerging technologies such as pluripotent stem cells and conducting well-designed trials will harness the full potential of cell-based therapy in AMI management. Collaborative efforts are vital to developing effective stem cell therapies for AMI patients.
    MeSH term(s) Humans ; Induced Pluripotent Stem Cells/metabolism ; Myocardial Infarction/therapy ; Mesenchymal Stem Cells ; Stem Cell Transplantation ; Cell- and Tissue-Based Therapy ; Mesenchymal Stem Cell Transplantation
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2023.2245329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Mesenchymal stem cells' "garbage bags" at work: Treating radial nerve injury with mesenchymal stem cell-derived exosomes.

    Mushtaq, Mazhar / Zineldeen, Doaa Hussein / Mateen, Muhammad Abdul / Haider, Khawaja Husnain

    World journal of stem cells

    2024  Volume 16, Issue 5, Page(s) 467–478

    Abstract: ... based therapy and cell-free therapy approaches using stem cell-derived soluble and insoluble ... components of the cell secretome are fast-emerging therapeutic approaches to treating acute and chronic PNI. The recent ... the best of novel treatment approaches to address the complexity of the neural repair and regeneration. ...

    Abstract Unlike central nervous system injuries, peripheral nerve injuries (PNIs) are often characterized by more or less successful axonal regeneration. However, structural and functional recovery is a senile process involving multifaceted cellular and molecular processes. The contemporary treatment options are limited, with surgical intervention as the gold-standard method; however, each treatment option has its associated limitations, especially when the injury is severe with a large gap. Recent advancements in cell-based therapy and cell-free therapy approaches using stem cell-derived soluble and insoluble components of the cell secretome are fast-emerging therapeutic approaches to treating acute and chronic PNI. The recent pilot study is a leap forward in the field, which is expected to pave the way for more enormous, systematic, and well-designed clinical trials to assess the therapeutic efficacy of mesenchymal stem cell-derived exosomes as a bio-drug either alone or as part of a combinatorial approach, in an attempt synergize the best of novel treatment approaches to address the complexity of the neural repair and regeneration.
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 2583482-4
    ISSN 1948-0210
    ISSN 1948-0210
    DOI 10.4252/wjsc.v16.i5.467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Regenerative treatment of ophthalmic diseases with stem cells: Principles, progress, and challenges.

    Niu, Yifei / Ji, Junfeng / Yao, Ke / Fu, Qiuli

    Advances in ophthalmology practice and research

    2024  Volume 4, Issue 2, Page(s) 52–64

    Abstract: ... their functional cells. Currently, stem cell therapy for ophthalmopathy involves various cell types ... making stem cell therapy emerge as a promising approach for treating a wide range of eye disorders ... These therapies aim to address the loss of functional cells, restore damaged ocular tissue and or in a paracrine ...

    Abstract Background: Degenerate eye disorders, such as glaucoma, cataracts and age-related macular degeneration (AMD), are prevalent causes of blindness and visual impairment worldwide. Other eye disorders, including limbal stem cell deficiency (LSCD), dry eye diseases (DED), and retinitis pigmentosa (RP), result in symptoms such as ocular discomfort and impaired visual function, significantly impacting quality of life. Traditional therapies are limited, primarily focus on delaying disease progression, while emerging stem cell therapy directly targets ocular tissues, aiming to restore ocular function by reconstructing ocular tissue.
    Main text: The utilization of stem cells for the treatment of diverse degenerative ocular diseases is becoming increasingly significant, owing to the regenerative and malleable properties of stem cells and their functional cells. Currently, stem cell therapy for ophthalmopathy involves various cell types, such as embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs), and retinal progenitor cells (RPCs). In the current article, we will review the current progress regarding the utilization of stem cells for the regeneration of ocular tissue covering key eye tissues from the cornea to the retina. These therapies aim to address the loss of functional cells, restore damaged ocular tissue and or in a paracrine-mediated manner. We also provide an overview of the ocular disorders that stem cell therapy is targeting, as well as the difficulties and opportunities in this field.
    Conclusions: Stem cells can not only promote tissue regeneration but also release exosomes to mitigate inflammation and provide neuroprotection, making stem cell therapy emerge as a promising approach for treating a wide range of eye disorders through multiple mechanisms.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2667-3762
    ISSN (online) 2667-3762
    DOI 10.1016/j.aopr.2024.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Emerging Strategies in Mesenchymal Stem Cell-Based Cardiovascular Therapeutics.

    Kumar, Rishabh / Mishra, Nitin / Tran, Talan / Kumar, Munish / Vijayaraghavalu, Sivakumar / Gurusamy, Narasimman

    Cells

    2024  Volume 13, Issue 10

    Abstract: ... of stem cell research related to cardiovascular diseases, highlighting foundational therapeutic approaches and ... solutions. This review delves into the transformative role of mesenchymal stem cells (MSCs) in advancing ... repair; and institutionalizing good manufacturing practice protocols to ensure therapeutic safety and ...

    Abstract Cardiovascular diseases continue to challenge global health, demanding innovative therapeutic solutions. This review delves into the transformative role of mesenchymal stem cells (MSCs) in advancing cardiovascular therapeutics. Beginning with a historical perspective, we trace the development of stem cell research related to cardiovascular diseases, highlighting foundational therapeutic approaches and the evolution of cell-based treatments. Recognizing the inherent challenges of MSC-based cardiovascular therapeutics, which range from understanding the pro-reparative activity of MSCs to tailoring patient-specific treatments, we emphasize the need to refine the pro-regenerative capacity of these cells. Crucially, our focus then shifts to the strategies of the fourth generation of cell-based therapies: leveraging the secretomic prowess of MSCs, particularly the role of extracellular vesicles; integrating biocompatible scaffolds and artificial sheets to amplify MSCs' potential; adopting three-dimensional ex vivo propagation tailored to specific tissue niches; harnessing the promise of genetic modifications for targeted tissue repair; and institutionalizing good manufacturing practice protocols to ensure therapeutic safety and efficacy. We conclude with reflections on these advancements, envisaging a future landscape redefined by MSCs in cardiovascular regeneration. This review offers both a consolidation of our current understanding and a view toward imminent therapeutic horizons.
    MeSH term(s) Humans ; Mesenchymal Stem Cells/cytology ; Cardiovascular Diseases/therapy ; Mesenchymal Stem Cell Transplantation/methods ; Animals ; Extracellular Vesicles/metabolism ; Extracellular Vesicles/transplantation ; Cell- and Tissue-Based Therapy/methods
    Language English
    Publishing date 2024-05-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13100855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Mesenchymal stem cell-derived exosomes for management of prostate cancer: An updated view.

    Lavi Arab, Fahimeh / Hoseinzadeh, Akram / Hafezi, Fatemeh / Sadat Mohammadi, Fatemeh / Zeynali, Farid / Hadad Tehran, Melika / Rostami, Amirreza

    International immunopharmacology

    2024  Volume 134, Page(s) 112171

    Abstract: ... therapeutic agents and induce an anti-tumor phenotype in immune cells and their recruitment to the tumor site ... effective and targeted approach to prostate cancer treatment. Moreover, the new generation of exosomes ... into the application of extracellular vesicle (EV)-MSC therapy as a novel treatment option that could provide a more ...

    Abstract Prostate cancer represents the second most prevalent form of cancer found in males, and stands as the fifth primary contributor to cancer-induced mortality on a global scale. Research has shown that transplanted mesenchymal stem cells (MSCs) can migrate by homing to tumor sites in the body. In prostate cancer, researchers have explored the fact that MSC-based therapies (including genetically modified delivery vehicles or vectors) and MSC-derived exosomes are emerging as attractive options to improve the efficacy and safety of traditional cancer therapies. In addition, researchers have reported new insights into the application of extracellular vesicle (EV)-MSC therapy as a novel treatment option that could provide a more effective and targeted approach to prostate cancer treatment. Moreover, the new generation of exosomes, which contain biologically functional molecules as signal transducers between cells, can simultaneously deliver different therapeutic agents and induce an anti-tumor phenotype in immune cells and their recruitment to the tumor site. The results of the current research on the use of MSCs in the treatment of prostate cancer may be helpful to researchers and clinicians working in this field. Nevertheless, it is crucial to emphasize that although dual-role MSCs show promise as a therapeutic modality for managing prostate cancer, further investigation is imperative to comprehensively grasp their safety and effectiveness. Ongoing clinical trials are being conducted to assess the viability of MSCs in the management of prostate cancer. The results of these trials will help determine the viability of this approach. Based on the current literature, engineered MSCs-EV offer great potential for application in targeted tumor therapy.
    Language English
    Publishing date 2024-05-02
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2024.112171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mesenchymal Stem Cells-based Cell-free Therapy Targeting Neuroinflammation.

    Xu, Hongjie / Wang, Bin / Li, Ang / Wen, Jing / Su, Huanxing / Qin, Dajiang

    Aging and disease

    2024  Volume 15, Issue 3, Page(s) 965–976

    Abstract: ... of mesenchymal stem cell-based cell-free therapy. This therapeutic strategy includes the regulation of microglia and ... This innovative therapeutic approach intricately modulates the immune system across the peripheral and nervous systems ... Emerging from several decades of extensive research, key genetic elements and biochemical ...

    Abstract Emerging from several decades of extensive research, key genetic elements and biochemical mechanisms implicated in neuroinflammation have been delineated, contributing substantially to our understanding of neurodegenerative diseases (NDDs). In this minireview, we discuss data predominantly from the past three years, highlighting the pivotal roles and mechanisms of the two principal cell types implicated in neuroinflammation. The review also underscores the extended process of peripheral inflammation that predates symptomatic onset, the critical influence of neuroinflammation, and their dynamic interplay in the pathogenesis of NDDs. Confronting these complex challenges, we introduce compelling evidence supporting the use of mesenchymal stem cell-based cell-free therapy. This therapeutic strategy includes the regulation of microglia and astrocytes, modulation of peripheral nerve cell inflammation, and targeted anti-inflammatory interventions specifically designed for NDDs, while also discussing engineering and safety considerations. This innovative therapeutic approach intricately modulates the immune system across the peripheral and nervous systems, with an emphasis on achieving superior penetration and targeted delivery. The insights offered by this review have significant implications for the better understanding and management of neuroinflammation.
    MeSH term(s) Humans ; Neuroinflammatory Diseases/therapy ; Neuroinflammatory Diseases/immunology ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells/immunology ; Mesenchymal Stem Cells/metabolism ; Neurodegenerative Diseases/therapy ; Neurodegenerative Diseases/immunology ; Animals ; Microglia/metabolism ; Microglia/immunology ; Inflammation/therapy ; Astrocytes/metabolism
    Language English
    Publishing date 2024-05-07
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2625789-0
    ISSN 2152-5250 ; 2152-5250
    ISSN (online) 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2023.0904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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