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  1. Article ; Online: Geriatric antibody response to COVID-19.

    Moore, Joshua / Groves, Tyler / Pilkerton, Courtney S / Ashcraft, Amie M / Shrader, Carl D

    Journal of the American Geriatrics Society

    2021  Volume 69, Issue 8, Page(s) 2096–2098

    MeSH term(s) Aged, 80 and over ; Antibody Formation/immunology ; COVID-19/epidemiology ; Comorbidity ; Disease Progression ; Geriatrics/statistics & numerical data ; Humans ; Immunoglobulin G ; Long-Term Care ; Time Factors ; West Virginia/epidemiology
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.17210
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.168: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Immunogenicity and reactogenicity of repeated intradermal mRNA COVID-19 vaccines administered as a second booster dose in a Thai geriatric population.

    Assantachai, Prasert / Niyomnaitham, Suvimol / Toh, Zheng Quan / Thammasalee, Monthira / Pengsorn, Napaporn / Monklang, Wiyachatr / Licciardi, Paul V / Chokephaibulkit, Kulkanya

    Frontiers in immunology

    2024  Volume 14, Page(s) 1302041

    Abstract: ... hospitalization, and loss of life from COVID-19. Few studies have explored vaccination regimens in adults >65 ... years old. Repeated booster vaccination is required for high-risk populations as COVID-19 vaccine ... 19 booster vaccination with second intramuscular (IM) vaccination in older adults.: Methods ...

    Abstract Background: Geriatric populations are at an increased risk of severe presentations, hospitalization, and loss of life from COVID-19. Few studies have explored vaccination regimens in adults >65 years old. Repeated booster vaccination is required for high-risk populations as COVID-19 vaccine efficacy is short-lived. We compared the immunogenicity and reactogenicity of second intradermal (ID) COVID-19 booster vaccination with second intramuscular (IM) vaccination in older adults.
    Methods: This single-center, open-labeled, prospective, cohort study conducted at Siriraj Hospital enrolled older adults ≥65 years old who previously received a first booster (third dose) mRNA vaccine (mRNA-1273 or BNT162b2) via ID or IM administration. Participants were allocated to receive a second booster of the same vaccine type and route as their first booster 16-17 weeks thereafter. Anti-SARS-CoV-2 receptor binding domain IgG and neutralizing antibody titers against Wuhan and Omicron subvariants (BA.1, BA.2, and BA.4/5) were measured 2 weeks after vaccination.
    Results: Of 91 enrolled participants, 72.5% were women, with a median age of 75 years. Forty-nine participants (53.8%) received a second ID booster, and 42 (46.2%) received a second IM booster. Two weeks after the second booster, all groups generated anamnestic IgG antibody responses that were 5.41- to 10.00-fold higher than at baseline. Overall, higher antibody GMTs against Wuhan and Omicron subvariants were observed in IM compared with ID regimens. ID mRNA-1273 induced similar GMTs to IM BNT162b2 2 weeks after the second booster against Wuhan (486.77 [321.48, 737.05] vs. 472.63 [291.24, 767.01], respectively;
    Conclusion: Repeated fractional ID vaccination may be an alternative booster vaccination strategy for geriatric populations.
    MeSH term(s) Humans ; Aged ; Female ; Male ; COVID-19 Vaccines/adverse effects ; BNT162 Vaccine ; 2019-nCoV Vaccine mRNA-1273 ; Cohort Studies ; Prospective Studies ; Thailand ; COVID-19/prevention & control ; Antibodies, Viral ; Immunoglobulin G ; RNA, Messenger
    Chemical Substances COVID-19 Vaccines ; BNT162 Vaccine ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; Antibodies, Viral ; Immunoglobulin G ; RNA, Messenger
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1302041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Antibody response with SARS-CoV-2 inactivated vaccine (CoronaVac) in Turkish geriatric population.

    Okyar Baş, Arzu / Hafizoğlu, Merve / Akbiyik, Filiz / Güner Oytun, Merve / Şahiner, Zeynep / Ceylan, Serdar / Ünsal, Pelin / Doğu, Burcu Balam / Cankurtaran, Mustafa / Çakir, Banu / Ünal, Serhat / Halil, Meltem Gülhan

    Age and ageing

    2022  Volume 51, Issue 5

    Abstract: ... limited data on the COVID-19 vaccine response in the geriatric population. This study aimed to assess ... studies are needed to confirm the antibody response duration and the association between frailty and COVID ... the second dose of the COVID-19 vaccine were included. Comprehensive geriatric assessment tools and ...

    Abstract Background: Sars-CoV-2 infection influences older individuals at the forefront, and there is still limited data on the COVID-19 vaccine response in the geriatric population. This study aimed to assess antibody response after vaccination with SARS-CoV-2 inactivated vaccine and examine possible factors affecting this response in a geriatric population.
    Methods: individuals who have been on at least the 28th day after the second dose of the COVID-19 vaccine were included. Comprehensive geriatric assessment tools and the Clinical Frailty Scale were performed. SARS-CoV-2 spike-specific IgG antibodies were detected and, levels ≥1 U/ml were defined as seropositive, <1 U/ml were defined as seronegative.
    Results: a total of 497 patients were included and divided into three groups according to the days past after the second dose of the vaccine (Group 1: 28-59 days, Group 2: 60-89 days and Group 3: 90 days and more). Groups included 188, 148 and 171 patients, respectively. Seropositivity rate in each group was 80.9,73.2 and 57.3%, respectively. In Groups 1 and 2, Charlson Comorbidity Index score was higher in the seronegative group (P = 0.023 and P = 0.011, respectively). In Group 3, the prevalence of frailty was significantly higher in the seronegative group (P = 0.002).
    Conclusion: to the best of our knowledge, this is the first study assessing the antibody response after vaccination with Sars-CoV 2 inactivated vaccine in the Turkish geriatric population. Moreover, this is the first study revealing the relationship between antibody response and frailty. Larger studies are needed to confirm the antibody response duration and the association between frailty and COVID-19 vaccine response.
    MeSH term(s) Aged ; Antibodies, Viral ; Antibody Formation ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Frailty ; Humans ; SARS-CoV-2 ; Vaccines, Inactivated
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; SARS-CoV-2 inactivated vaccines ; Vaccines, Inactivated
    Language English
    Publishing date 2022-05-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 186788-x
    ISSN 1468-2834 ; 0002-0729
    ISSN (online) 1468-2834
    ISSN 0002-0729
    DOI 10.1093/ageing/afac088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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