Article: Linking membrane trafficking and intestinal homeostasis.
Tissue barriers
2014 Volume 1, Issue 1, Page(s) e23119
Abstract: ... communities that colonize their intestines. Although several molecules important for intestinal homeostasis ... a forward genetic approach, which revealed several molecules essential for intestinal homeostasis. One ... in intestinal homeostasis with a specific focus on the Yip family members. We speculate on how deficiency or ...
| Abstract | A major challenge for the human body is to maintain symbiotic relationships with bacterial communities that colonize their intestines. Although several molecules important for intestinal homeostasis have been discovered, the vast array still needs to be identified. We approached this task using a forward genetic approach, which revealed several molecules essential for intestinal homeostasis. One recently identified molecule is Ypt1p-interacting protein 1 domain family, member 6 (Yipf6). Mice with a null mutation in Yipf6 are hypersensitive to dextran sulfate sodium (DSS) induced colitis and develop spontaneous intestinal inflammation. Members of the Yip1 family are believed to be involved in ER to Golgi membrane transport. In this review we summarize recent advances in the understanding of genes involved in intestinal homeostasis with a specific focus on the Yip family members. We speculate on how deficiency or dysfunction of Yip molecules may dysregulate intestinal homeostasis leading to pathogenic states. |
|---|---|
| Language | English |
| Publishing date | 2014-02-09 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2168-8362 |
| ISSN | 2168-8362 |
| DOI | 10.4161/tisb.23119 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Inter-library loan at ZB MED
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.