Article ; Online: Ventilator-associated bacterial pneumonia in coronavirus 2019 disease, a retrospective monocentric cohort study.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
2021 Volume 27, Issue 6, Page(s) 826–833
Abstract: Introduction: Severe coronavirus 2019 disease (CoViD-19) may lead to respiratory failure and ... mechanical ventilation. Therefore, ventilator associated pneumonia (VAP) may complicate the course of the disease ... on a retrospective manner, in a cohort of mechanically ventilated CoViD-19 patients. Additionally, determinant ...
| Abstract | Introduction: Severe coronavirus 2019 disease (CoViD-19) may lead to respiratory failure and mechanical ventilation. Therefore, ventilator associated pneumonia (VAP) may complicate the course of the disease. The aim of the current article was to investigate possible predictive factors for bacterial VAP on a retrospective manner, in a cohort of mechanically ventilated CoViD-19 patients. Additionally, determinant factors of lethality were analyzed. Methods: Medical records of patients hospitalized in the intensive care units (ICU) at the university hospital UZ Brussel during the epidemic were reviewed. VAP was defined following the National Healthcare Safety Network 2017 criteria. Univariate and multivariate logistic regressions analyses were performed. Results: Among the 39 patients included in the study, 54% were diagnosed with bacterial VAP. Case fatality rate was 44%, but 59% of the deceased patients had a do-not-resuscitate status. Multivariate logistic regression for prediction of VAP showed significant differences in duration of ICU hospitalization and in minimal lung compliance. Additional analyses were performed on CoViD-19 patients who were affected by bacterial respiratory superinfection. The responsible pathogens correspond to the commonly found bacteria in VAP. However, 71% of the isolated germs were multi-drug resistant and bacteraemia was reported in 38%. Multivariate analyses for prediction of lethality found significant difference in SOFA score. Conclusions: Mechanically ventilated CoViD-19 patients might frequently develop VAP. Longer ICU hospitalization was associated with pulmonary superinfection in the current cohort. Moreover, decreased minimal lung compliance was correlated to VAP and higher SOFA score at VAP diagnosis was associated with lethality. |
|||||
|---|---|---|---|---|---|---|
| MeSH term(s) | Aged ; COVID-19/epidemiology ; Female ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Pneumonia, Bacterial/epidemiology ; Pneumonia, Bacterial/mortality ; Pneumonia, Ventilator-Associated/epidemiology ; Pneumonia, Ventilator-Associated/microbiology ; Pneumonia, Ventilator-Associated/mortality ; Respiration, Artificial ; Retrospective Studies ; Ventilators, Mechanical | |||||
| Language | English | |||||
| Publishing date | 2021-01-23 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1355399-9 | |||||
| ISSN | 1437-7780 ; 1341-321X | |||||
| ISSN (online) | 1437-7780 | |||||
| ISSN | 1341-321X | |||||
| DOI | 10.1016/j.jiac.2021.01.011 | |||||
| Shelf mark |
|
|||||
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 5236: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.