Article: Effect of Hochu-ekki-to (TJ-41), a Japanese herbal medicine, on the survival of mice infected with influenza virus.
1999 Volume 44, Issue 2, Page(s) 103–111
Abstract: ... mice infected with influenza virus. TJ-41 was found to increase the survival rate, prolong the mean ... The antiviral effect of Hochu-ekki-to (TJ-41), a Japanese herbal medicine, was investigated using ... on day 2 after infection. Yet, TJ-41 did not show any inhibitory effect on the growth of influenza virus ...
| Abstract | The antiviral effect of Hochu-ekki-to (TJ-41), a Japanese herbal medicine, was investigated using mice infected with influenza virus. TJ-41 was found to increase the survival rate, prolong the mean survival days, suppress viral growth in bronchoalveolar labage fluid (BALF) and inhibit the lung index (lung consolidation) on day 4 after infection in mice infected with influenza, after the agent had been administered orally once daily from day 7 to 2 before infection and from day 0 to 4 after infection. Administration of TJ-41 decreased the BALF concentrations of IL-1alpha, IL-6 and GM-CSF, but not TNF-alpha or interferon-gamma (IFN-gamma), on day 4 after infection. In addition, TJ-41 elevated the level of IFN-alpha in BALF on day 2 after infection. Yet, TJ-41 did not show any inhibitory effect on the growth of influenza virus in vitro. These results suggest that TJ-41 exerts its inhibitory effect on influenza virus infection via enhancement of the host immune responses in this experimental murine system. |
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| MeSH term(s) | Administration, Oral ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Bronchoalveolar Lavage Fluid/chemistry ; Chromatography, High Pressure Liquid ; Cytokines/analysis ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Enzyme-Linked Immunosorbent Assay ; Granulocyte-Macrophage Colony-Stimulating Factor/analysis ; Influenza A virus/drug effects ; Influenza A virus/immunology ; Interferon-gamma/analysis ; Interleukin-1/analysis ; Interleukin-6/analysis ; Male ; Mice ; Mice, Inbred BALB C ; Orthomyxoviridae Infections/drug therapy ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/virology ; Tumor Necrosis Factor-alpha/analysis | |||||
| Chemical Substances | Antiviral Agents ; Cytokines ; Drugs, Chinese Herbal ; Interleukin-1 ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; bu-zhong-yi-qi-tang ; Interferon-gamma (82115-62-6) ; Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1) | |||||
| Language | English | |||||
| Publishing date | 1999-12-15 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 306628-9 | |||||
| ISSN | 1872-9096 ; 0166-3542 | |||||
| ISSN (online) | 1872-9096 | |||||
| ISSN | 0166-3542 | |||||
| DOI | 10.1016/s0166-3542(99)00048-0 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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