Article ; Online: Distinct clinical and immunological profiles of patients with evidence of SARS-CoV-2 infection in sub-Saharan Africa.
2021 Volume 12, Issue 1, Page(s) 3554
Abstract: ... to understand clinical and immunological responses in African populations. Here we characterise patients ... inflammatory profiles analogous to PCR-confirmed disease and potentially represent a target population ... predominated by chemokines and neutrophils and distinct from PCR-negative/IgG-negative participants. PCR ...
| Abstract | Although the COVID-19 pandemic has left no country untouched there has been limited research to understand clinical and immunological responses in African populations. Here we characterise patients hospitalised with suspected (PCR-negative/IgG-positive) or confirmed (PCR-positive) COVID-19, and healthy community controls (PCR-negative/IgG-negative). PCR-positive COVID-19 participants were more likely to receive dexamethasone and a beta-lactam antibiotic, and survive to hospital discharge than PCR-negative/IgG-positive and PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants exhibited a nasal and systemic cytokine signature analogous to PCR-positive COVID-19 participants, predominated by chemokines and neutrophils and distinct from PCR-negative/IgG-negative participants. PCR-negative/IgG-positive participants had increased propensity for Staphylococcus aureus and Streptococcus pneumoniae colonisation. PCR-negative/IgG-positive individuals with high COVID-19 clinical suspicion had inflammatory profiles analogous to PCR-confirmed disease and potentially represent a target population for COVID-19 treatment strategies. |
|---|---|
| MeSH term(s) | Adult ; Africa South of the Sahara/epidemiology ; Anti-Bacterial Agents/administration & dosage ; Antibodies/blood ; COVID-19/blood ; COVID-19/epidemiology ; COVID-19/immunology ; Coinfection/immunology ; Cytokines/blood ; Dexamethasone/administration & dosage ; Female ; Humans ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Male ; Middle Aged ; Pandemics ; SARS-CoV-2/isolation & purification ; COVID-19 Drug Treatment |
| Chemical Substances | Anti-Bacterial Agents ; Antibodies ; Cytokines ; Immunoglobulin G ; Immunoglobulin M ; Dexamethasone (7S5I7G3JQL) |
| Language | English |
| Publishing date | 2021-06-11 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2553671-0 |
| ISSN | 2041-1723 ; 2041-1723 |
| ISSN (online) | 2041-1723 |
| ISSN | 2041-1723 |
| DOI | 10.1038/s41467-021-23267-w |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.