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Article: Primary Ewing sarcoma of rib.

Moser, R P / Davis, M J / Gilkey, F W / Kransdorf, M J / Rosado de Christenson, M L / Kumar, R / Bloem, J L / Stull, M A

Radiographics : a review publication of the Radiological Society of North America, Inc

1990 Volume 10, Issue 5, Page(s) 899–914

Abstract: ... of radiologic findings of primary Ewing sarcoma of rib, augmented where appropriate by accompanying pathologic ... Ewing sarcoma is a relatively common, highly malignant bone tumor that typically occurs ... radiologically correlated Ewing sarcoma collected in consultation over 40 years. From this series, we identified ...

Abstract	Ewing sarcoma is a relatively common, highly malignant bone tumor that typically occurs in adolescents and young adults aged 10-25 years. Our archives contain 328 cases of histologically proved and radiologically correlated Ewing sarcoma collected in consultation over 40 years. From this series, we identified 34 lesions (10%) arising in ribs. Radiographically, the affected rib was predominantly lytic in most (82%) cases, but mixed lytic-sclerotic (9%) and even predominantly sclerotic (9%) patterns were also encountered. The affected rib was "expanded" in 35% of cases, although the contour change was usually mild. Abnormalities of the affected ipsilateral hemithorax varied from subtle, isolated rib involvement to solitary rib involvement accompanied by complete opacification of the hemithorax. We describe the spectrum of radiologic findings of primary Ewing sarcoma of rib, augmented where appropriate by accompanying pathologic material.
MeSH term(s)	Adolescent ; Adult ; Bone Neoplasms/pathology ; Child ; Child, Preschool ; Female ; Humans ; Male ; Ribs/pathology ; Sarcoma, Ewing/pathology
Language	English
Publishing date	1990-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/radiographics.10.5.2217978
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Article ; Online: Prognostic factors in primary nonmetastatic Ewing sarcoma of the rib in children and young adults.

Qureshi, Sajid S / Kembhavi, Seema / Vora, Tushar / Ramadwar, Mukta / Laskar, Siddharth / Talole, Sanjay / Kurkure, Purna

Journal of pediatric surgery

2013 Volume 48, Issue 4, Page(s) 764–770

Abstract: Background: The rarity of Ewing sarcoma of rib has resulted in paucity of data, particularly ... nonmetastatic Ewing sarcoma of the rib and examined prognostic factors of poor outcome.: Methods ... from costal cartilage to vertebra) or partial excision of involved rib with or without adjacent ribs was ...

Abstract	Background: The rarity of Ewing sarcoma of rib has resulted in paucity of data, particularly on the prognostic factors and pattern of relapses. We analyzed the recurrences in patients with primary nonmetastatic Ewing sarcoma of the rib and examined prognostic factors of poor outcome. Methods: From January 2004 to January 2011, 37 patients were treated. After induction chemotherapy, complete (from costal cartilage to vertebra) or partial excision of involved rib with or without adjacent ribs was performed. Postoperative radiotherapy was administered for positive margins, poor response to chemotherapy, and large primary tumors with significant soft tissue component at presentation. Results: Disease relapsed in 16 patients: at the local site (n = 5), both local and distant (n = 2), and distant site only (n = 9). The projected 5-year cause-specific, relapse-free survival and local control were 50%, 44%, and 72%. Poor response to chemotherapy (>5% residual tumor) and resection of adjacent lung parenchyma (a surrogate for tumor extension) were adverse prognostic factors for relapse-free survival in multivariate analysis. Conclusion: Relapses occurred more often at distant sites and had a poor outcome. In this study, poor histologic response to chemotherapy (P = .04) and the infiltration of adjacent lung parenchyma (P = .01) are adverse prognostic factors.
MeSH term(s)	Adolescent ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Chi-Square Distribution ; Child ; Child, Preschool ; Combined Modality Therapy ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; Positron-Emission Tomography ; Prognosis ; Proportional Hazards Models ; Radiotherapy Dosage ; Ribs/pathology ; Risk Factors ; Sarcoma, Ewing/diagnosis ; Sarcoma, Ewing/pathology ; Sarcoma, Ewing/therapy ; Survival Rate ; Thoracotomy ; Tomography, X-Ray Computed ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2013-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2012.07.049
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Article ; Online: Scoliosis After Resection of Primary Pediatric Chest Wall Tumors.

Ahmed, Gehad / Emran, Ihab M / Rashad, Ismail / Zaghloul, Mohamed S / Mahrous, Mary Rabea / Tabl, Yomna Abo / Elshafiey, Maged

Journal of pediatric surgery

2024

Abstract: ... of 10 years. The most common histology was Ewing sarcoma (n = 57). A median of 3 (range, 1-5) contiguous ... for scoliosis were resecting 3 or more ribs (OR 6.44) and resection of the posterior rib segment (OR 5.49 ... with resection involving three or more ribs and resection of the posterior rib sector.: Type ...

Abstract	Background: Scoliosis is one of the long-term consequences of surgical resection of pediatric chest wall tumors. This study aimed to identify the risk factors associated with scoliosis development following the resection of chest wall tumors. Methods: Retrospective cohort study of 64 children who underwent resection of malignant chest wall tumors from 2009 to 2022. Univariate and multivariate analyses were used to investigate factors associated with scoliosis development. Results: The median age at the time of surgery was 7 years (range, 3-21), with 33 (51.6%) patients undergoing surgery before the age of 10 years. The most common histology was Ewing sarcoma (n = 57). A median of 3 (range, 1-5) contiguous ribs were resected. A total of 34 (53.1%) patients had anterior CWTs and 30 (46.9%) had posterior CWTs. Concomitant partial lung and diaphragmatic resection were performed in 12 patients (lung, n = 7; diaphragm, n = 5). Scoliosis convex towards the resection side developed in 21 (32.8%). The primary risk factors for scoliosis were resecting 3 or more ribs (OR 6.44) and resection of the posterior rib segment (OR 5.49). Patients with a tumor resection below 10 years old were not associated with a higher risk of scoliosis. Conclusions: Scoliosis following resection of a primary malignant pediatric chest wall tumor is associated with resection involving three or more ribs and resection of the posterior rib sector. Type of study: Retrospective observational. Level of evidence: IV.
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	80165-3
ISSN	1531-5037 ; 0022-3468
ISSN (online)	1531-5037
ISSN	0022-3468
DOI	10.1016/j.jpedsurg.2024.04.015
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Article: Oncological results in primary and secondary malignant chest wall tumors.

Kocaman, Gökhan / Kahya, Yusuf / Konuk Balcı, Buse Mine / Yenigün, Bülent Mustafa / Özkan, Murat / Özakıncı, Hilal / Karasoy, Duru / Yüksel, Cabir / Enön, Serkan / Kayı Cangır, Ayten

Turk gogus kalp damar cerrahisi dergisi

2024 Volume 32, Issue 1, Page(s) 55–61

Abstract: ... tumor type (primary/secondary), histological tumor type, grade, stage, complete resection, rib resection ... due to lung cancer invasion (46.8%), followed by Ewing sarcoma (13%). Recurrence was observed in 34 ... tumor grade and rib resection were found to be independent prognostic factors for both recurrence-free ...

Abstract	Background: This study aims to evaluate the oncological results of primary and secondary chest wall tumors treated with curative resections and to investigate possible prognostic factors. Methods: Between January 2010 and December 2021, a total of 77 patients (53 males, 24 females; median age: 59 years; range, 3 to 87 years) who underwent curative resection for malignant chest wall tumors were retrospectively analyzed. Each tumor was staged according to its histological type. Age, sex, tumor diameter, tumor type (primary/secondary), histological tumor type, grade, stage, complete resection, rib resection, reconstruction, neoadjuvant and adjuvant therapy, recurrence, and survival data were recorded. Results: Of the chest wall tumors, 33 (42.9%) were primary and 44 (57.1%) were secondary (local invasion, metastasis). Nine (11.7%) patients had positive surgical margins. Chest wall resection was most commonly performed due to lung cancer invasion (46.8%), followed by Ewing sarcoma (13%). Recurrence was observed in 34 (44.2%) patients. The five-year recurrence-free survival rate was 42.7% and the five-year overall survival rate was 58.6%. There was no significant difference between the primary and secondary tumors in terms of recurrence-free and overall survival (p=0.663 and p=0.313, respectively). In the multivariate analysis, tumor grade and rib resection were found to be independent prognostic factors for both recurrence-free survival (p=0.005 and p<0.001, respectively) and overall survival (p=0.048 and p=0.007, respectively). Conclusion: Successful oncological results can be achieved in wellselected patients with primary and secondary chest wall tumors. The grade of the tumor should be taken into account while determining the neoadjuvant or adjuvant treatment approach and surgical margin width. Rib resection should not be avoided when necessary.
Language	English
Publishing date	2024-01-29
Publishing country	Turkey
Document type	Journal Article
ISSN	1301-5680
ISSN	1301-5680
DOI	10.5606/tgkdc.dergisi.2024.25393
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Article: Primary Ewing Sarcoma of the Cervical Spine: A Case Report and Literature Review.

Shihadeh, Omar M / Khan, Muhammad Mohsin / Salih, Hayel / Thabet, Abdelnaser / Belkhair, Sirajeddin

Cureus

2023 Volume 15, Issue 7, Page(s) e42687

Abstract: ... cases of Ewing sarcoma occur in intra-skeletal locations (long bones, pelvis, or ribs) and rarely ... extramedullary Ewing sarcoma (IEES) is extremely rare. Fifty cases of primary IEES including our case were ... Ewing sarcoma is a rare neoplasm that mostly grows in bones or soft tissues around bones. Most ...

Abstract	Ewing sarcoma is a rare neoplasm that mostly grows in bones or soft tissues around bones. Most cases of Ewing sarcoma occur in intra-skeletal locations (long bones, pelvis, or ribs) and rarely in extra-skeletal regions such as paravertebral or epidural space, whereas a primary intradural extramedullary Ewing sarcoma (IEES) is extremely rare. Fifty cases of primary IEES including our case were identified in the literature, so far, of which two-thirds are in the lumbosacral region, while only 12 reports described a cervical location of the tumor. Herein, we are presenting a case of C7-T1 primary IEES for a 24-year-old male, followed by a review of updated literature about the primary IEES in the cervical spine.
Language	English
Publishing date	2023-07-30
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.42687
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Article: Case report: Primary pleural giant extraskeletal Ewing sarcoma in a child.

Wu, Yang / Xie, Chao-Bang / Huang, Qiong / Zhao, Kai-Fei

Frontiers in oncology

2023 Volume 13, Page(s) 1137586

Abstract: Primary extraskeletal Ewing sarcoma (EES) is a rare small round cell malignancy that accounts ... Ewing sarcoma. To inhibit tumor growth, alternating systemic chemotherapy cycles of vincristine, doxorubicin ... destruction of the adjacent left first rib. The patient's bone scan showed a dense focus of increased ...

Abstract	Primary extraskeletal Ewing sarcoma (EES) is a rare small round cell malignancy that accounts for less than 1% of all sarcomas. It is found most commonly in the trunk and lower limbs and very rarely in the pleura and can be easily misdiagnosed in clinical practice. This study presents the case of an 11-year-old boy who presented to our hospital with no apparent cause of left shoulder pain for 6 months. On physical examination, tenderness was noted in the left chest wall and shoulder joint, which had a limited range of motion. Computed tomography (CT) and magnetic resonance imaging (MRI) of the chest revealed an irregular soft tissue mass in the upper left thorax, with a wide base attached to the adjacent pleura and bone destruction of the adjacent left first rib. The patient's bone scan showed a dense focus of increased radiotracer accumulation in the left first rib. A subsequent CT-guided aspiration biopsy of the left pleural mass with histomorphology and immunohistochemical phenotyping led to a diagnosis of extraskeletal Ewing sarcoma. To inhibit tumor growth, alternating systemic chemotherapy cycles of vincristine, doxorubicin, and cyclophosphamide (VDC) and isocyclophosphamide and etoposide (IE) were administered at 3-week intervals. After completing three VDC and two IE cycles, the child's condition was well and the pain in the left shoulder joint was relieved. However, a repeat MRI of the chest showed that the mass did not shrink.
Language	English
Publishing date	2023-03-31
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1137586
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Article ; Online: Ewing Sarcoma-Chest Wall Reconstruction Following Resection of Rare Primary Chest Wall Tumor.

Sakharuk, Ilya / McKinley, Thomas / Moore, Gabrielle / Miller, Daniel

The American surgeon

2024 , Page(s) 31348241241635

Abstract: Ewing sarcoma (ES) represents the second most common primary osseous malignancy in children and ... tumor of the ribs and/or chest wall. These tumors are known as Askin's tumors and most commonly present ...

Abstract	Ewing sarcoma (ES) represents the second most common primary osseous malignancy in children and young adults, most often occurring in the diaphysis of the long bones. While rare, ES can present as an osseous tumor of the ribs and/or chest wall. These tumors are known as Askin's tumors and most commonly present with symptoms resembling pneumonia. We report the case of a 26-year-old man who was found to have a right lung mass extending into his anterolateral chest wall after presenting to the hospital for evaluation of unremitting chest pain. Biopsy was performed and the patient diagnosed with ES. After completion of neoadjuvant chemotherapy, the patient underwent resection of the right chest wall mass. The chest wall was reconstructed in a novel fashion with titanium plates and a reinforced tissue matrix patch. Due to a paucity of cases, no treatment or reconstruction algorithm currently exists for management of these malignancies.
Language	English
Publishing date	2024-03-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/00031348241241635
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Article: Primary Ewing sarcoma/primitive neuroectodermal tumor of the lung.

Gupta, Devika / Chatterjee, Tathagata / Tewari, Rohit / Trehan, Arti / Ahuja, Anuradha

Autopsy & case reports

2020 Volume 10, Issue 3, Page(s) e2020199

Abstract: ... as all other visceral organs were unremarkable grossly. Histopathology confirmed primary Ewing sarcoma of the lung ... We hereby, report a rare case of primary lung Ewing sarcoma diagnosed at autopsy. ... by a necrotic growth which was deeply adherent to the rib cage. The contralateral lung as well ...

Abstract	We present the autopsy findings and differential diagnosis in a 42year old male who presented with fever and rapidly progressive respiratory symptoms like breathlessness, nonproductive cough and right sided chest pain. Initial imaging workup done at our hospital revealed a large unilateral tumor with tracheal shift. While being evaluated patient developed facial puffiness, tachypnea suggestive of superior vena cava obstruction. Antemortem biopsy of lung mass was attempted twice and that suggested malignant lesion. Unfortunately, the individual had a rapid downhill course following admission. Post mortem examination was conducted that on opening the thoracic cavity revealed total replacement of right lung tissue by a necrotic growth which was deeply adherent to the rib cage. The contralateral lung as well as all other visceral organs were unremarkable grossly. Histopathology confirmed primary Ewing sarcoma of the lung. We hereby, report a rare case of primary lung Ewing sarcoma diagnosed at autopsy.
Language	English
Publishing date	2020-09-02
Publishing country	Brazil
Document type	Case Reports
ZDB-ID	2815488-5
ISSN	2236-1960
ISSN	2236-1960
DOI	10.4322/acr.2020.199
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Article: [Effective radiation therapy of two cases of primary Ewing's sarcoma of the rib].

Nakanishi, K / Ajimu, A / Ishida, Y / Fujimoto, T / Hayashi, K / Hombo, Z / Amamoto, Y

Gan no rinsho. Japan journal of cancer clinics

1987 Volume 33, Issue 7, Page(s) 834–840

Abstract: Two cases of primary Ewing's sarcoma of the rib are reported, in which radiation therapy was quite ... tumor dose 74 Gy) was given for primary Ewing's sarcoma of the left 6th rib. The tumor became small and ... for Ewing's sarcoma of the left 7th rib. She was referred to our hospital after a recurrent tumor was found ...

Abstract	Two cases of primary Ewing's sarcoma of the rib are reported, in which radiation therapy was quite effective. Case 1 was an 18-year-old female who had had an operation and radiation therapy for Ewing's sarcoma of the left 7th rib. She was referred to our hospital after a recurrent tumor was found. Radiation therapy (tumor dose 46.2 Gy) and chemotherapy were given. The tumor disappeared and there has been no relapse for 1 year and 3 months after the treatment. Case 2 was a 2-year-old-infant. Radiation therapy (tumor dose 74 Gy) was given for primary Ewing's sarcoma of the left 6th rib. The tumor became small and was successfully removed at operation. There has been no relapse or distant metastasis for 8 months following the operation. We emphasize the importance of multidisciplinary treatment in case 1 and the usefulness of preoperative radiotherapy in case 2.
MeSH term(s)	Adolescent ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bone Neoplasms/drug therapy ; Bone Neoplasms/radiotherapy ; Bone Neoplasms/surgery ; Child, Preschool ; Combined Modality Therapy ; Female ; Humans ; Male ; Prognosis ; Radiotherapy Dosage ; Radiotherapy, High-Energy ; Ribs ; Sarcoma, Ewing/drug therapy ; Sarcoma, Ewing/radiotherapy ; Sarcoma, Ewing/surgery
Language	Japanese
Publishing date	1987-06
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	603145-6
ISSN	0021-4949
ISSN	0021-4949
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Article ; Online: Primary Ewing sarcoma/primitive neuroectodermal tumor of the lung

Devika Gupta / Tathagata Chatterjee / Rohit Tewari / Arti Trehan / Anuradha Ahuja

Autopsy and Case Reports, Vol 10, Iss

2021 Volume 3

Abstract	We present the autopsy findings and differential diagnosis in a 42year old male who presented with fever and rapidly progressive respiratory symptoms like breathlessness, nonproductive cough and right sided chest pain. Initial imaging workup done at our hospital revealed a large unilateral tumor with tracheal shift. While being evaluated patient developed facial puffiness, tachypnea suggestive of superior vena cava obstruction. Antemortem biopsy of lung mass was attempted twice and that suggested malignant lesion. Unfortunately, the individual had a rapid downhill course following admission. Post mortem examination was conducted that on opening the thoracic cavity revealed total replacement of right lung tissue by a necrotic growth which was deeply adherent to the rib cage. The contralateral lung as well as all other visceral organs were unremarkable grossly. Histopathology confirmed primary Ewing sarcoma of the lung. We hereby, report a rare case of primary lung Ewing sarcoma diagnosed at autopsy.
Keywords	Ewing sarcoma ; extraosseous ; Lung ; Medicine ; R ; Internal medicine ; RC31-1245
Subject code	610
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	University of São Paulo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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