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  1. Article: Organ-on-chip models: new opportunities for biomedical research.

    Mosig, Alexander S

    Future science OA

    2016  Volume 3, Issue 2, Page(s) FSO130

    Language English
    Publishing date 2016-07-06
    Publishing country England
    Document type Editorial
    ISSN 2056-5623
    ISSN 2056-5623
    DOI 10.4155/fsoa-2016-0038
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  2. Article ; Online: Organ-on-a-chip technology for the study of the female reproductive system.

    Young, Rachel E / Huh, Dan Dongeun

    Advanced drug delivery reviews

    2021  Volume 173, Page(s) 461–478

    Abstract: ... reproductive diseases. We also present two case studies that use organ-on-a-chip design principles to model ... Finally, we discuss challenges and opportunities for the advancement of reproductive organ-on-a-chip ... these systems offer great promise to advance the frontiers of basic and translational research in biomedical ...

    Abstract Over the past decade, organs-on-a-chip and microphysiological systems have emerged as a disruptive in vitro technology for biopharmaceutical applications. By enabling new capabilities to engineer physiological living tissues and organ units in the precisely controlled environment of microfabricated devices, these systems offer great promise to advance the frontiers of basic and translational research in biomedical sciences. Here, we review an emerging body of interdisciplinary work directed towards harnessing the power of organ-on-a-chip technology for reproductive biology and medicine. The focus of this topical review is to provide an overview of recent progress in the development of microengineered female reproductive organ models with relevance to drug delivery and discovery. We introduce the engineering design of these advanced in vitro systems and examine their applications in the study of pregnancy, infertility, and reproductive diseases. We also present two case studies that use organ-on-a-chip design principles to model placental drug transport and hormonally regulated crosstalk between multiple female reproductive organs. Finally, we discuss challenges and opportunities for the advancement of reproductive organ-on-a-chip technology.
    MeSH term(s) Drug Delivery Systems ; Drug Discovery ; Female ; Genitalia, Female/drug effects ; Humans ; Lab-On-A-Chip Devices ; Tissue Engineering
    Language English
    Publishing date 2021-04-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2021.03.010
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  3. Article: Bioinspired Engineering of Organ-on-Chip Devices.

    Wang, Li / Li, Zhongyu / Xu, Cong / Qin, Jianhua

    Advances in experimental medicine and biology

    2019  Volume 1174, Page(s) 401–440

    Abstract: ... of the emerging organs-on-chips and their proof-of-concept applications in biomedical research. We also discuss ... While traditional cell culture models have led to new insights into the cellular microenvironment and ... interactions within the cellular microenvironment in a more relevant organ context. Engineering organ-on-chip systems offers ...

    Abstract The human body can be viewed as an organism consisting of a variety of cellular and non-cellular materials interacting in a highly ordered manner. Its complex and hierarchical nature inspires the multi-level recapitulation of the human body in order to gain insights into the inner workings of life. While traditional cell culture models have led to new insights into the cellular microenvironment and biological control in vivo, deeper understanding of biological systems and human pathophysiology requires the development of novel model systems that allow for analysis of complex internal and external interactions within the cellular microenvironment in a more relevant organ context. Engineering organ-on-chip systems offers an unprecedented opportunity to unravel the complex and hierarchical nature of human organs. In this chapter, we first highlight the advances in microfluidic platforms that enable engineering of the cellular microenvironment and the transition from cells-on-chips to organs-on-chips. Then, we introduce the key features of the emerging organs-on-chips and their proof-of-concept applications in biomedical research. We also discuss the challenges and future outlooks of this state-of-the-art technology.
    MeSH term(s) Cellular Microenvironment ; Humans ; Microfluidics/trends ; Models, Biological ; Organ Culture Techniques/trends ; Physiology/trends ; Tissue Engineering/trends
    Language English
    Publishing date 2019-11-11
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-13-9791-2_13
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  4. Article ; Online: 3D organ models-Revolution in pharmacological research?

    Weinhart, Marie / Hocke, Andreas / Hippenstiel, Stefan / Kurreck, Jens / Hedtrich, Sarah

    Pharmacological research

    2018  Volume 139, Page(s) 446–451

    Abstract: 3D organ models have gained increasing attention as novel preclinical test systems and ... several organ models on a single device and interlink these within a human-like environment. In contrast ... microfluidic organ-on-a-chip tissue cultures have gained increasing interest for their ability to house ...

    Abstract 3D organ models have gained increasing attention as novel preclinical test systems and alternatives to animal testing. Over the years, many excellent in vitro tissue models have been developed. In parallel, microfluidic organ-on-a-chip tissue cultures have gained increasing interest for their ability to house several organ models on a single device and interlink these within a human-like environment. In contrast to these advancements, the development of human disease models is still in its infancy. Although major advances have recently been made, efforts still need to be intensified. Human disease models have proven valuable for their ability to closely mimic disease patterns in vitro, permitting the study of pathophysiological features and new treatment options. Although animal studies remain the gold standard for preclinical testing, they have major drawbacks such as high cost and ongoing controversy over their predictive value for several human conditions. Moreover, there is growing political and social pressure to develop alternatives to animal models, clearly promoting the search for valid, cost-efficient and easy-to-handle systems lacking interspecies-related differences. In this review, we discuss the current state of the art regarding 3D organ as well as the opportunities, limitations and future implications of their use.
    MeSH term(s) Animals ; Biomedical Research ; Epithelium ; Humans ; Liver ; Models, Biological ; Pharmacology/methods ; Printing, Three-Dimensional ; Tissue Engineering
    Keywords covid19
    Language English
    Publishing date 2018-11-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1003347-6
    ISSN 1096-1186 ; 0031-6989 ; 1043-6618
    ISSN (online) 1096-1186
    ISSN 0031-6989 ; 1043-6618
    DOI 10.1016/j.phrs.2018.11.002
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  5. Article ; Online: Organ-on-a-Chip Systems for Women's Health Applications.

    Nawroth, Janna / Rogal, Julia / Weiss, Martin / Brucker, Sara Y / Loskill, Peter

    Advanced healthcare materials

    2017  Volume 7, Issue 2

    Abstract: ... where organ-on-a-chip systems are already utilized or have the potential to deliver new insights and enable ... Biomedical research, for a long time, has paid little attention to the influence of sex ... of microphysiological organ-on-a-chip systems, which attempt to recreate the 3D structure and function of human organs ...

    Abstract Biomedical research, for a long time, has paid little attention to the influence of sex in many areas of study, ranging from molecular and cellular biology to animal models and clinical studies on human subjects. Many studies solely rely on male cells/tissues/animals/humans, although there are profound differences in male and female physiology, which can significantly impact disease mechanisms, toxicity of compounds, and efficacy of pharmaceuticals. In vitro systems have been traditionally very limited in their capacity to recapitulate female-specific physiology and anatomy such as dynamic sex-hormone levels and the complex interdependencies of female reproductive tract organs. However, the advent of microphysiological organ-on-a-chip systems, which attempt to recreate the 3D structure and function of human organs, now gives researchers the opportunity to integrate cells and tissues from a variety of individuals. Moreover, adding a dynamic flow environment allows mimicking endocrine signaling during the menstrual cycle and pregnancy, as well as providing a controlled microfluidic environment for pharmacokinetic modeling. This review gives an introduction into preclinical and clinical research on women's health and discusses where organ-on-a-chip systems are already utilized or have the potential to deliver new insights and enable entirely new types of studies.
    MeSH term(s) Female ; Humans ; Lab-On-A-Chip Devices ; Pharmacokinetics ; Women's Health
    Language English
    Publishing date 2017-10-06
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.201700550
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  6. Article ; Online: Organ-on-a-Chip systems for women's health applications

    Nawroth, Janna / Rogal, Julia / Weiss, Martin / Brucker, Sara Y. / Loskill, Peter

    2018  

    Abstract: ... where organ-on-a-chip systems are already utilized or have the potential to deliver new insights and enable ... Art. 1700550 ... Biomedical research, for a long time, has paid little attention to the influence ...

    Abstract Art. 1700550

    Biomedical research, for a long time, has paid little attention to the influence of sex in many areas of study, ranging from molecular and cellular biology to animal models and clinical studies on human subjects. Many studies solely rely on male cells/tissues/animals/humans, although there are profound differences in male and female physiology, which can significantly impact disease mechanisms, toxicity of compounds, and efficacy of pharmaceuticals. In vitro systems have been traditionally very limited in their capacity to recapitulate female-specific physiology and anatomy such as dynamic sex-hormone levels and the complex interdependencies of female reproductive tract organs. However, the advent of microphysiological organ-on-a-chip systems, which attempt to recreate the 3D structure and function of human organs, now gives researchers the opportunity to integrate cells and tissues from a variety of individuals. Moreover, adding a dynamic flow environment allows mimicking endocrine signaling during the menstrual cycle and pregnancy, as well as providing a controlled microfluidic environment for pharmacokinetic modeling. This review gives an introduction into preclinical and clinical research on women's health and discusses where organ-on-a-chip systems are already utilized or have the potential to deliver new insights and enable entirely new types of studies.

    7

    Nr.2, Special Issue: Microphysiological Analytic Platforms (MAPs): Precision Organs on Chip
    Keywords hormones ; microphysiological systems ; organ-on-a-chip ; sex differences ; women's health ; 660 ; 610 ; 620
    Subject code 590
    Language English
    Publishing country de
    Document type Article ; Online
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  7. Article: Organs-on-a-Chip Module: A Review from the Development and Applications Perspective.

    Sosa-Hernández, Juan Eduardo / Villalba-Rodríguez, Angel M / Romero-Castillo, Kenya D / Aguilar-Aguila-Isaías, Mauricio A / García-Reyes, Isaac E / Hernández-Antonio, Arturo / Ahmed, Ishtiaq / Sharma, Ashutosh / Parra-Saldívar, Roberto / Iqbal, Hafiz M N

    Micromachines

    2018  Volume 9, Issue 10

    Abstract: ... recent progress of organs-on-chip research. Herein, we also point out some opportunities for microfluidic ... in vivo models offering new approaches to research in medicine, biology, and pharmacology, among others ... for numerous applications with special reference to bioengineering and biomedical engineering research ...

    Abstract In recent years, ever-increasing scientific knowledge and modern high-tech advancements in micro- and nano-scales fabrication technologies have impacted significantly on various scientific fields. A micro-level approach so-called "microfluidic technology" has rapidly evolved as a powerful tool for numerous applications with special reference to bioengineering and biomedical engineering research. Therefore, a transformative effect has been felt, for instance, in biological sample handling, analyte sensing cell-based assay, tissue engineering, molecular diagnostics, and drug screening, etc. Besides such huge multi-functional potentialities, microfluidic technology also offers the opportunity to mimic different organs to address the complexity of animal-based testing models effectively. The combination of fluid physics along with three-dimensional (3-D) cell compartmentalization has sustained popularity as organ-on-a-chip. In this context, simple humanoid model systems which are important for a wide range of research fields rely on the development of a microfluidic system. The basic idea is to provide an artificial testing subject that resembles the human body in every aspect. For instance, drug testing in the pharma industry is crucial to assure proper function. Development of microfluidic-based technology bridges the gap between in vitro and in vivo models offering new approaches to research in medicine, biology, and pharmacology, among others. This is also because microfluidic-based 3-D niche has enormous potential to accommodate cells/tissues to create a physiologically relevant environment, thus, bridge/fill in the gap between extensively studied animal models and human-based clinical trials. This review highlights principles, fabrication techniques, and recent progress of organs-on-chip research. Herein, we also point out some opportunities for microfluidic technology in the future research which is still infancy to accurately design, address and mimic the in vivo niche.
    Language English
    Publishing date 2018-10-22
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi9100536
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  8. Article ; Online: Advances in Microfluidic Technologies in Organoid Research.

    Liu, Haitao / Gan, Zhongqiao / Qin, Xinyuan / Wang, Yaqing / Qin, Jianhua

    Advanced healthcare materials

    2023  , Page(s) e2302686

    Abstract: Organoids have emerged as major technological breakthroughs and novel organ models that have ... revolutionized biomedical research by recapitulating the key structural and functional complexities ... and microfluidics that lie ahead to accelerate research in organ development, disease studies ...

    Abstract Organoids have emerged as major technological breakthroughs and novel organ models that have revolutionized biomedical research by recapitulating the key structural and functional complexities of their in vivo counterparts. The combination of organoid systems and microfluidic technologies has opened new frontiers in organoid engineering and offers great opportunities to address the current challenges of existing organoid systems and broaden their biomedical applications. In this review, the key features of the existing organoids, including their origins, development, design principles, and limitations, are described. Then the recent progress in integrating organoids into microfluidic systems is highlighted, involving microarrays for high-throughput organoid manipulation, microreactors for organoid hydrogel scaffold fabrication, and microfluidic chips for functional organoid culture. The opportunities in the nascent combination of organoids and microfluidics that lie ahead to accelerate research in organ development, disease studies, drug screening, and regenerative medicine are also discussed. Finally, the challenges and future perspectives in the development of advanced microfluidic platforms and modified technologies for building organoids with higher fidelity and standardization are envisioned.
    Language English
    Publishing date 2023-12-22
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.202302686
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