Article ; Online: Association between coronary artery calcifications and 6-month mortality in hospitalized patients with COVID-19.
Diagnostic and interventional imaging
2021 Volume 102, Issue 12, Page(s) 717–725
Abstract: ... independently associated with 6-month mortality in patients hospitalized for severe COVID-19 pneumonia. ... CAC) visual score and 6-month mortality in patients with coronavirus disease 2019 (COVID-19 ... consecutive hospitalized patients between March 13 and April 1, 2020, and follow-up for 6-months. A four-level ...
| Abstract | Purpose: The purpose of this study was to evaluate the association between coronary artery calcium (CAC) visual score and 6-month mortality in patients with coronavirus disease 2019 (COVID-19). Material and methods: A single-center prospective observational cohort was conducted in 169 COVID-19 consecutive hospitalized patients between March 13 and April 1, 2020, and follow-up for 6-months. A four-level visual CAC scoring was assessed by analyzing images obtained after the first routine non-ECG-gated CT performed to detect COVID-19 pneumonia. Results: Among 169 confirmed COVID-19 patients (118 men, 51 women; mean age, 65.6 ± 18.8 [SD] years; age range: 30-95 years) 63 (37%) presented with either moderate (n = 26, 15.3%) or heavy (n = 37, 21.8%) CAC detected by CT and 20 (11.8%) had history of cardiovascular disease requiring specific preventive treatment. At six months, mortality rate (45/169; 26.6%) increased with magnitude of CAC and was 7/64 (10.9%), 11/42 (26.2%), 10/26 (38.5%), 17/37 (45.9%) for no-CAC, mild-CAC, moderate-CAC and heavy-CAC groups, respectively (P = 0.001). Compared to the no CAC group, risk of death increased after adjustment with magnitude of CAC (HR: 2.23, 95% CI: 0.73-6.87, P = 0.16; HR: 2.78, 95% CI: 0.85-9.07, P0.09; HR: 5.38, 95% CI: 1.57-18.40, P = 0.007; in mild CAC, moderate and heavy CAC groups, respectively). In patients without previous coronary artery disease (154/169; 91%), mortality increased from 10.9% to 45.8% (P = 0.001) according to the magnitude of CAC categories. After adjustment, presence of moderate or heavy CAC was associated with higher mortality (HR: 2.26, 95% CI: 1.09-4.69, P = 0.03). Conclusion: By using non-ECG-gated CT during the initial pulmonary assessment of COVID-19, heavy CAC is independently associated with 6-month mortality in patients hospitalized for severe COVID-19 pneumonia. |
|---|---|
| MeSH term(s) | Adult ; Aged ; Aged, 80 and over ; COVID-19 ; Coronary Angiography ; Coronary Artery Disease/diagnostic imaging ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Risk Assessment ; Risk Factors ; SARS-CoV-2 ; Vascular Calcification/diagnostic imaging |
| Language | English |
| Publishing date | 2021-07-13 |
| Publishing country | France |
| Document type | Journal Article ; Observational Study |
| ZDB-ID | 2648283-6 |
| ISSN | 2211-5684 ; 2211-5684 |
| ISSN (online) | 2211-5684 |
| ISSN | 2211-5684 |
| DOI | 10.1016/j.diii.2021.06.007 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
Full text online
More links
Kategorien
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.