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Article: Studies of humoral and cell-mediated immunity in human melanoma.

Mukherji, B / Nathanson, L / Clark, D A

The Yale journal of biology and medicine

1973 Volume 46, Issue 5, Page(s) 681–692

MeSH term(s)	Animals ; Antibodies, Neoplasm/analysis ; Antibody Formation ; Antibody Specificity ; Antigens, Neoplasm/analysis ; Cell Line ; Cell Membrane/immunology ; Cytotoxicity Tests, Immunologic ; Epitopes ; Fluorescent Antibody Technique ; Histocompatibility Antigens/analysis ; Humans ; Hypersensitivity, Delayed ; Immunity, Cellular ; Melanoma/immunology ; Neoplasm Metastasis ; Neoplasm Transplantation ; Phenotype ; Rats ; T-Lymphocytes/immunology ; Transplantation Immunology ; Transplantation, Heterologous
Chemical Substances	Antibodies, Neoplasm ; Antigens, Neoplasm ; Epitopes ; Histocompatibility Antigens
Language	English
Publishing date	1973-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	200515-3
ISSN	1551-4056 ; 0044-0086
ISSN (online)	1551-4056
ISSN	0044-0086
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Article: Halo giant congenital melanocytic nevus: in vitro immunologic studies.

Berman, B / Shaieb, A M / France, D S / Altchek, D D

Journal of the American Academy of Dermatology

1988 Volume 19, Issue 5 Pt 2, Page(s) 954–960

Abstract: ... of melanoma cell growth was detected by the use of the patient's mononuclear cells. Therefore both humoral and ... cells isolated from the pigmented nevus and specifically to cells of a human melanoma line in a complement ... cell-mediated immunity may be involved in nevus cell rejection and halo formation. ...

Abstract	We have assessed in vitro humoral and cell-mediated immune reactions of a patient with a giant congenital melanocytic nevus that showed clinical and histologic evidence of spontaneous regression. Nevus cell-specific antibody was detected in the patient's serum, which was cytotoxic to epidermal cells isolated from the pigmented nevus and specifically to cells of a human melanoma line in a complement-dependent fashion. The presence of epidermal Langerhans cells, known to be antigen-presenting cells, was required for nevus cell-specific activation of the patient's T lymphocytes. Antibody-independent inhibition of melanoma cell growth was detected by the use of the patient's mononuclear cells. Therefore both humoral and cell-mediated immunity may be involved in nevus cell rejection and halo formation.
MeSH term(s)	Child ; Complement C3/analysis ; Cytotoxicity, Immunologic ; DNA, Neoplasm/biosynthesis ; Female ; Fluorescent Antibody Technique ; Humans ; Immunoglobulin G/analysis ; In Vitro Techniques ; Langerhans Cells/immunology ; Neoplasm Regression, Spontaneous ; Nevus, Pigmented/congenital ; Nevus, Pigmented/immunology ; Rosette Formation
Chemical Substances	Complement C3 ; DNA, Neoplasm ; Immunoglobulin G
Language	English
Publishing date	1988-11
Publishing country	United States
Document type	Case Reports ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/s0190-9622(88)70258-3
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Article: In vitro studies of cytokine-mediated interactions between malignant glioma and autologous peripheral blood mononuclear cells.

Jachimczak, P / Schwulera, U / Bogdahn, U

Journal of neurosurgery

1994 Volume 81, Issue 4, Page(s) 579–586

Abstract: The humoral interactions between three malignant glioma early-passage cell cultures and in vitro ... investigated, employing standard and modified (separated by permeable membranes) mixed lymphocyte tumor cell ... and tumor necrosis factor-alpha, which may modulate glioma cell proliferation. None of these cytokines ...

Abstract	The humoral interactions between three malignant glioma early-passage cell cultures and in vitro interleukin (IL)-1 alpha- and IL-2-activated autologous peripheral blood mononuclear cells (PBMC's) were investigated, employing standard and modified (separated by permeable membranes) mixed lymphocyte tumor cell (MLTC) cultures. In modified MLTC's, glioma cells clearly inhibit proliferation of PBMC's (up to 60%), whereas lymphokine-activated PBMC's enhance glioma cell growth up to 12-fold, as determined by 3H-thymidine incorporation assays. Glioma cells produce both stimulatory (IL-6) and inhibitory proteins (transforming growth factor-beta) for PBMC's. Lymphokine-activated PBMC's secrete IL-1 alpha, IL-2, IL-4, IL-6, interferon-gamma, and tumor necrosis factor-alpha, which may modulate glioma cell proliferation. None of these cytokines stimulated glioma cells as intensely as modified MLTC systems. These observations indicate that in vitro lymphokine-activated PBMC's, although suppressed by humoral glioma-derived factors, may enhance glioma cell proliferation with soluble factors secreted into the culture medium. The authors conclude that glioma-lymphocyte growth regulatory networks include stimulatory and inhibitory factors from both cell populations, which may modulate tumor progression. These observations may have relevance for adoptive immunotherapy in patients with gliomas.
MeSH term(s)	Cells, Cultured ; Cytokines/immunology ; Glioblastoma/immunology ; Humans ; Immunity, Cellular/immunology ; Immunohistochemistry ; Leukocytes, Mononuclear/immunology ; Lymphocyte Subsets/classification ; Phenotype ; Tumor Cells, Cultured
Chemical Substances	Cytokines
Language	English
Publishing date	1994-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/jns.1994.81.4.0579
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Article: Experimental studies on bacterial product CANTASTIM derived from Pseudomonas aeruginosa with immunomodulatory properties. IV. Tyrosine phosphorylation as an effect of stimulation on different cell populations.

Onu, A / Stefanescu, M / Matache, C / Salageanu, A / Istrate, N / Szegli, G

Roumanian archives of microbiology and immunology

1997 Volume 56, Issue 1-2, Page(s) 37–45

Abstract: ... could be mentioned: an increase of the activated T cell subpopulations and humoral-mediated immune ... and a monocyte cell line (THP-1). In PBL, the treatment with CANTASTIM renders them more susceptible ... to CD3 stimulation than non-treated cells. In monocytes, CANTASTIM and two phospholipid components ...

Abstract	The bacterial product derived from Pseudomonas aeruginosa (trade mark-CANTASTIM) proved immunomodulatory effects in different systems, both in vitro and in vivo experimental animal models, as well as in clinical trials. Among the results obtained regarding CANTASTIM, the following immunomodulatory properties could be mentioned: an increase of the activated T cell subpopulations and humoral-mediated immune processes, facilitation of phagocytic processes, stimulation of cytotoxic activity reflected in the improvement of the capacity of defense in several tumoral and infectious diseases. To better elucidate the intimate mechanisms by which CANTASTIM modulates the cellular functions on different cellular populations, we used tyrosine phosphorylation as an estimate of cell activation on peripheral blood lymphocytes (PBL) and a monocyte cell line (THP-1). In PBL, the treatment with CANTASTIM renders them more susceptible to CD3 stimulation than non-treated cells. In monocytes, CANTASTIM and two phospholipid components of CANTASTIM modulated in a different manner the cellular adhesion on fibronectin and tyrosine phosphorylation leading to the conclusion that these phospholipid components do not fully explain CANTASTIM modulatory properties on cell adhesion processes.
MeSH term(s)	Adjuvants, Immunologic/pharmacology ; Cell Adhesion/drug effects ; Cell Line ; Humans ; Lymphocyte Activation/drug effects ; Phospholipids ; Phosphorylation ; Pseudomonas aeruginosa/chemistry ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; Tyrosine/metabolism
Chemical Substances	Adjuvants, Immunologic ; Phospholipids ; cantastim ; Tyrosine (42HK56048U)
Language	English
Publishing date	1997-01
Publishing country	Romania
Document type	Journal Article
ZDB-ID	1101928-1
ISSN	1222-3891
ISSN	1222-3891
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Zs.A 86: Show issues

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Article: Preliminary studies of sera and urine from patients with bladder cancer.

Hollinshead, A C

National Cancer Institute monograph

1978 , Issue 49, Page(s) 193–197

Abstract: Some preliminary observations may be helpful as we proceed with studies of the humoral and cellular ... cancer-related cell and urine components. We can study differentiation of such antigens from TAA ... which produce cell-mediated immune responses. ...

Abstract	Some preliminary observations may be helpful as we proceed with studies of the humoral and cellular reactions in body fluids. 1) In the reactions with TAA from primary bladder cancers and from bladder cancer cell lines, we must be aware of complexing when we study sera or tumors from patients with more invasive tumors. 2) Earlier stage patient sera can react to antigens present in urine but may not react with antigens present on tumor cells. These reactions are mainly related to cell sediments or partially insoluble material present in the urine; it is difficult to interpret these reactions in a controlled study. 3) Using sera from patients with different stages of bladder cancer, we can test normal bladder cell lines (e.g., HCV-29, which has no CF reactivity with sera from patients with bladder cancer) for comparison with the patterns of TAA present in cancer cell lines (e.g., RT-4 and T-24). 4) There is no relationship between HSV and bladder TCC. 5) Cytomegalovirus and its components are associated with normal or cancer-related cell and urine components. We can study differentiation of such antigens from TAA, which produce cell-mediated immune responses.
MeSH term(s)	Adult ; Aged ; Antigens, Neoplasm/isolation & purification ; Antigens, Neoplasm/urine ; Antigens, Viral/isolation & purification ; Carcinoma, Transitional Cell/immunology ; Carcinoma, Transitional Cell/urine ; Cell Line ; Complement Fixation Tests ; Cytomegalovirus/immunology ; Female ; Humans ; Male ; Middle Aged ; Neoplasms, Experimental/immunology ; Urinary Bladder Neoplasms/immunology ; Urinary Bladder Neoplasms/urine
Chemical Substances	Antigens, Neoplasm ; Antigens, Viral
Language	English
Publishing date	1978-12
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ISSN	0083-1921
ISSN	0083-1921
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Ud III 1370: Show issues

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Article: In vitro cytotoxicity studies in bladder and renal cell cancer.

Elhilali, M M / Nayak, S K

Urology

1976 Volume 7, Issue 5, Page(s) 488–491

Abstract: ... with success to obtain primary cultures in 25 and long-term cultures in 7. Cell-mediated and humoral immunity ... against target cells obtained from metastatic cancer tissue. Abrogation of cell-mediated immunity by serum ... Attempts to obtain cell lines from bladder and renal cancer patients were done in 42 patients ...

Abstract	Attempts to obtain cell lines from bladder and renal cancer patients were done in 42 patients, with success to obtain primary cultures in 25 and long-term cultures in 7. Cell-mediated and humoral immunity was demonstrated in both tumors by microcytotoxicity in vitro. No cytotoxicity could be deomonstrated against target cells obtained from metastatic cancer tissue. Abrogation of cell-mediated immunity by serum factors was demonstrated. No recurrence was obtained in the group of patients showing positive lymphocytotoxicity during follow-up.
MeSH term(s)	Antibodies, Neoplasm/analysis ; Antigen-Antibody Reactions ; Carcinoma, Transitional Cell/immunology ; Cell Line ; Cells, Cultured ; Complement System Proteins ; Cytotoxicity Tests, Immunologic ; Humans ; Immunity, Cellular ; In Vitro Techniques ; Kidney Neoplasms/immunology ; Lymphocytes/immunology ; Urinary Bladder Neoplasms/immunology
Chemical Substances	Antibodies, Neoplasm ; Complement System Proteins (9007-36-7)
Language	English
Publishing date	1976-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/0090-4295(76)90185-0
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: [Studies on the pathophysiology of paraneoplastic syndromes: both cancer cells and host immune cells are responsible for the pathophysiology of leukocytosis associated with oral cancer].

Nishimura, R

Osaka Daigaku shigaku zasshi] The journal of Osaka University Dental Society

1990 Volume 35, Issue 1, Page(s) 147–179

Abstract: ... squamous cell carcinoma (MH85) and induced leukocytosis and splenomegaly. Leukocytosis and splenomegaly paralleled tumor ... likely that increased secretion of TNF and IL-1 by spleen cells that are stimulated by humoral factors ... weight, indicating an involvement of humoral mediators released by MH85. MH85 cells conditioned medium ...

Abstract	Leukocytosis associated with malignant disease has been known as a paraneoplastic syndrome and occurs occasionally in patients with oral malignancies. In this study, mechanisms underlying leukocytosis associated with malignancy was investigated, using a squamous cell carcinoma of the maxilla from a patient who manifested marked leukocytosis. When the patient's tumor was inoculated into nude mice, it formed squamous cell carcinoma (MH85) and induced leukocytosis and splenomegaly. Leukocytosis and splenomegaly paralleled tumor growth. Surgical excision of MH85 tumor resulted in a dramatic reduction of leukocyte count and spleen weight, indicating an involvement of humoral mediators released by MH85. MH85 cells conditioned medium (MH85CM) were shown to contain granulocyte-colony stimulating factor (G-CSF) activity, which is a potent growth factor specific for granulocytes. These results suggest G-CSF or G-CSF like substance secreted by MH85 cells is responsible for leukocytosis in MH85 bearing nude mice (MH85 mice) and in the patient. MH85 cell growth was stimulated by G-CSF and inhibited by anti-G-CSF antibody, thus suggesting that G-CSF like substance is a autocrine growth factor for MH85 cells. Splenectomized MH85 mice developed less severe leukocytosis than did non-splenectomized mice. This finding indicated that not only G-CSF like substance secreted by MH85 cells but other humoral factors released by the hyperplastic spleen contribute to the development of leukocytosis. Splenic monocytes derived from MH85 mice and MH85CM-stimulated splenic monocytes showed increased secretion of tumor necrosis factor (TNF) and interleukin-1 (IL-1), both of which have been reported to induce neutrophilia in animals. Moreover, injection of anti-TNF-antibody into neutrophilic MH85 mice significantly, although not completely, decreased leukocyte count. Thus, it seemed likely that increased secretion of TNF and IL-1 by spleen cells that are stimulated by humoral factors released from MH85 also contributes to the progression of leukocytosis. In splenectomized mice, enlargement of MH85 tumor was retarded and metastases were impaired compared these in nonsplenectomized mice. Coculture of splenocytes from MH85 mice with normal spleen cells, inhibited blastogenesis in response to mitogen. The result suggests that splenocytes from MH85 mice played as immune suppressive cells. MH85CM conferred immune suppressive activity on normal spleen cells. This suppressor cell-inducing factor (SCIF) in MH85CM was found to have an apparent molecular weight of approximately 25kd, and its biological activity was neutralized by anti-G-CSF antibody. Therefore, SCIF secreted by MH85 cells was likely to be G-CSF like substance.(ABSTRACT TRUNCATED AT 400 WORDS)
MeSH term(s)	Animals ; Carcinoma, Squamous Cell/complications ; Carcinoma, Squamous Cell/secretion ; Granulocyte Colony-Stimulating Factor/physiology ; Humans ; Immune Tolerance ; Interleukin-1/secretion ; Leukocytosis/etiology ; Leukocytosis/immunology ; Maxillary Neoplasms/complications ; Maxillary Neoplasms/secretion ; Mice ; Mice, Nude ; Spleen/immunology ; Spleen/secretion ; Splenectomy ; Tumor Necrosis Factor-alpha/secretion
Chemical Substances	Interleukin-1 ; Tumor Necrosis Factor-alpha ; Granulocyte Colony-Stimulating Factor (143011-72-7)
Language	Japanese
Publishing date	1990-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	632723-0
ISSN	0473-4629
ISSN	0473-4629
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Article: STUDY OF IMMUNO-PATHOGENETIC FEATURES OF PSORIASIS AND ACNE'S COURSE.

Dashko, Marianna / Syzon, Orysya / Voznyak, Iryna / Chaplyk-Chyzho, Iryna

Wiadomosci lekarskie (Warsaw, Poland : 1960)

2022 Volume 75, Issue 2, Page(s) 422–426

Abstract: ... with the depletion of T-cell immunity were found in patients with papular-pustular and pustular acne, and still more ... state T-cell link, amid an adequate humoral immunity have been found. Relationship between the causes ... probable changes in concentrations of stress-response mediators (decreased parameters of cellular immunity ...

Abstract	Objective: The aim: The objective of our work was to improve the diagnostics of common chronic dermatoses (acne, psoriasis, АР) taking into account some indicators of the immune system and features of the disease course to specify their role in pathogenesis of these disease. Patients and methods: Materials and methods: A total of 114 patients with acne and 128 patients with psoriasis were observed. Results: Results: Regardless of the disease duration period, we have detected in blood serum of psoriasis рatients probable changes in concentrations of stress-response mediators (decreased parameters of cellular immunity (CD3+, CD3+CD4+, CD3+CD8+ of T-lymphocytes, CD22+ fraction of B-lymphocytes and compensatory increased CD16+ of T-cells, cytokines - IL-1β, IL-8, IL- 17, IL-22, immunoglobulins IgM, IgG, and CIC), which indicate tension of their stress-induced mechanisms even despite occasional clinical stabilization of skin and articular process. Consequently, most of the patients with acne had varying degrees of changes in rates of systemic immunity. The most significant changes in rates of systemic immunity with the depletion of T-cell immunity were found in patients with papular-pustular and pustular acne, and still more significant - in patients with acne conglobate. Conclusion: Conclusions: In patients with acne and psoriasis, changes in systemic immunity indexes that indicate the formation of secondary immunodeficiency state T-cell link, amid an adequate humoral immunity have been found. Relationship between the causes of changes of systemic immunity has been established.
MeSH term(s)	Acne Vulgaris ; Humans ; Immunity, Cellular ; Psoriasis ; Skin/pathology ; T-Lymphocytes
Language	English
Publishing date	2022-03-17
Publishing country	Poland
Document type	Journal Article
ZDB-ID	414731-5
ISSN	0043-5147 ; 1895-0485 ; 0860-8865
ISSN	0043-5147 ; 1895-0485 ; 0860-8865
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Zs.A 646: Show issues

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Article ; Online: The dynamics of B-cell reconstitution post allogeneic hematopoietic stem cell transplantation: A real-world study.

Zhou, Guangyu / Zhan, Qian / Huang, Lingle / Dou, Xi / Cui, Jin / Xiang, Lin / Qi, Yuhong / Wu, Sicen / Liu, Lin / Xiao, Qing / Chen, Jianbin / Tang, Xiaoqiong / Zhang, Hongbin / Wang, Xin / Luo, Xiaohua / Ren, Guosheng / Yang, Zesong / Liu, Lanxiang / Yan, Xinyu /

Luo, Qin / Pei, Caixia / Dai, Yulian / Zhu, Yu / Zhou, Hao / Ren, Guilin / Wang, Li

Journal of internal medicine

2024 Volume 295, Issue 5, Page(s) 634–650

Abstract: ... B cells play an important role in humoral immunity and immune regulation, but their reconstitution after ... mediation analysis, we proposed the age-B cells-survival axis and found that B-cell reconstitution at month ... in 252 patients who underwent allo-HSCT for 2 years and assessed the impact of factors on B-cell ...

Abstract	Background: The immune reconstitution after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is crucial for preventing infections and relapse and enhancing graft-versus-tumor effects. B cells play an important role in humoral immunity and immune regulation, but their reconstitution after allo-HSCT has not been well studied. Methods: In this study, we analyzed the dynamics of B cells in 252 patients who underwent allo-HSCT for 2 years and assessed the impact of factors on B-cell reconstitution and their correlations with survival outcomes, as well as the development stages of B cells in the bone marrow and the subsets in the peripheral blood. Results: We found that the B-cell reconstitution in the bone marrow was consistent with the peripheral blood (p = 0.232). B-cell reconstitution was delayed by the male gender, age >50, older donor age, the occurrence of chronic and acute graft-versus-host disease, and the infections of fungi and cytomegalovirus. The survival analysis revealed that patients with lower B cells had higher risks of death and relapse. More importantly, we used propensity score matching to obtain the conclusion that post-1-year B-cell reconstitution is better in females. Meanwhile, using mediation analysis, we proposed the age-B cells-survival axis and found that B-cell reconstitution at month 12 posttransplant mediated the effect of age on patient survival (p = 0.013). We also found that younger patients showed more immature B cells in the bone marrow after transplantation (p = 0.037). Conclusion: Our findings provide valuable insights for optimizing the management of B-cell reconstitution and improving the efficacy and safety of allo-HSCT.
MeSH term(s)	Female ; Humans ; Male ; Transplantation, Homologous ; Hematopoietic Stem Cell Transplantation/adverse effects ; Graft vs Host Disease/etiology ; Graft vs Host Disease/prevention & control ; Graft vs Host Disease/epidemiology ; B-Lymphocytes ; Recurrence
Language	English
Publishing date	2024-03-04
Publishing country	England
Document type	Journal Article
ZDB-ID	96274-0
ISSN	1365-2796 ; 0954-6820
ISSN (online)	1365-2796
ISSN	0954-6820
DOI	10.1111/joim.13776
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Ua VI Zs.44: Show issues

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Article ; Online: Transplant rejections associated with immune checkpoint inhibitors: A pharmacovigilance study and systematic literature review.

Nguyen, Lee S / Ortuno, Sofia / Lebrun-Vignes, Bénédicte / Johnson, Douglas B / Moslehi, Javid J / Hertig, Alexandre / Salem, Joe-Elie

European journal of cancer (Oxford, England : 1990)

2021 Volume 148, Page(s) 36–47

Abstract: ... were mostly reported in kidney and liver transplant recipients. Rejections were T-cell mediated ... n = 5). The main indication reported for ICI was malignant melanoma (39/89, 43.8%). The time ... of transplant rejections following ICI were included, including kidney (n = 65), liver (n = 23), cornea (n = 2) and heart ...

Abstract	Background: Solid organ transplant recipients are at increased risk of cancer due to long-term immunosuppression. Immune-checkpoint inhibitors (ICI) showed clinical benefits but increased risk of transplant rejection. Our work aims to assess the main features of reported rejection events. Methods: A disproportionality analysis of the World Health Organisation pharmacovigilance database, VigiBase, to identify drugs associated with rejection events. The estimate of this analysis is the information component for which the lower end of the 95% credibility interval (IC Results: A total of 96 reports of transplant rejections following ICI were included, including kidney (n = 65), liver (n = 23), cornea (n = 2) and heart (n = 5). The main indication reported for ICI was malignant melanoma (39/89, 43.8%). The time to onset between first ICI administration and rejection was 21 [interquartile range: 13; 56] days. Kidney transplant rejection was associated with nivolumab (IC Conclusion: ICI-associated transplant rejections were mostly reported in kidney and liver transplant recipients. Rejections were T-cell mediated with low participation of humoral response.
MeSH term(s)	Graft Rejection/etiology ; Graft Rejection/pathology ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immunosuppression/adverse effects ; Organ Transplantation/adverse effects ; Pharmacovigilance ; Prognosis
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2021-03-12
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2021.01.038
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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