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Article ; Online: COVID-19 platform trial delivers.

Mullard, Asher

2020 Volume 19, Issue 8, Page(s) 501

Keywords	covid19
Language	English
Publishing date	2020-07-07
Publishing country	England
Document type	News
ZDB-ID	2062954-0
ISSN	1474-1784 ; 1474-1776
ISSN (online)	1474-1784
ISSN	1474-1776
DOI	10.1038/d41573-020-00128-7
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Article: COVID-19 platform trial delivers

Mullard, Asher

Nat Rev Drug Discov

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #636519
Database	COVID19

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Article ; Online: COVID-19 platform trial delivers

Mullard, Asher

Nature Reviews Drug Discovery

2020 Volume 19, Issue 8, Page(s) 501–501

Keywords	Pharmacology ; Drug Discovery ; General Medicine ; covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
ZDB-ID	2062954-0
ISSN	1474-1784 ; 1474-1776
ISSN (online)	1474-1784
ISSN	1474-1776
DOI	10.1038/d41573-020-00128-7
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The impact of COVID-19 on clinical research

Louise Larkin / Audrey C Tierney / Norelee Kennedy / Stephen Gallagher / Anusha Moses / Bente Appel Esbensen / Liam Glynn / Anne Griffin / Tala Raad / Alexander Fraser

HRB Open Research, Vol

the PIPPRA and MEDRA experience [version 2; peer review: 2 approved]

2023 Volume 4

Abstract: ... immunosuppressed and thus at a higher risk for COVID-19. The decision-making processes of both trials is outlined ... Background Coronavirus disease 2019 (COVID-19) has had a significant impact on clinical research ... This paper aims to provide an insight into how the COVID-19 pandemic, associated public health restrictions ...

Abstract	Background Coronavirus disease 2019 (COVID-19) has had a significant impact on clinical research. This paper aims to provide an insight into how the COVID-19 pandemic, associated public health restrictions and international guidance on the conduct of clinical research impacted two clinical rheumatology research trials - the Physiotherapist-led Intervention to Promote Physical Activity in Rheumatoid Arthritis (PIPPRA) and the MEDiterranean diet in Rheumatoid Arthritis (MEDRA) projects. Methods The March 2019 public health restrictions imposed to mitigate the risk of COVID-19 occurred at a time when PIPPRA was in the process of delivering assessment and intervention on a face-to-face basis (n=48) and MEDRA had commenced recruitment. Participants in PIPPRA and MEDRA had a diagnosis of rheumatoid arthritis, with some being immunosuppressed and thus at a higher risk for COVID-19. The decision-making processes of both trials is outlined to demonstrate the required amendments to continue in the context of the COVID-19 pandemic. Results Amendments to PIPPRA and MEDRA trial protocols were agreed and received ethical and funder approval. Both trials switched from a face-to-face delivery to a telehealth using online platforms. The PIPPRA study was paused for five months (April-August 2020), resulting in n=33 (60%) negative deviations from assessment protocol. MEDRA switched from face-to-face to online recruitment with 20% (n=35/44) negative deviations in recruitment. Of the n=18 participants who consented to participating in a face-to-face trial, just n=2 (11%) opted to engage with telehealth delivery of the intervention. MEDRA assessment and intervention deviations were 100% as no sessions were completed as planned in 2020. Conclusions The COVID-19 pandemic has severely impacted the PIPPRA and MEDRA clinical trials. Moving face-to-face clinical research to telehealth delivery may not be the panacea it is purported to be. Our experiences may be of benefit to researchers, clinicians, and funders in seeking to continue ...
Keywords	Clinical research ; rheumatology ; COVID-19 ; pandemic ; feasibility ; eng ; Medicine ; R
Subject code	170
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	F1000 Research Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The impact of COVID-19 on the clinical trial.

Chen, Zhimin / Chen, Liran / Chen, Huafang

PloS one

2021 Volume 16, Issue 5, Page(s) e0251410

Abstract: ... of follow-up, delivery of clinical trial drugs by express, additional workload caused by screening ... with clinical trial staff and clinical trial subjects were surveyed by questionnaire in this study. The results ... platforms, telemedicine and follow-up by video, A large number of deviations from protocol and losses ...

Abstract	The objective of this study was to explore the impact of the coronavirus disease 2019 epidemic on ongoing and upcoming drug clinical trials. Qualitative semi-structured interviews were conducted with clinical trial staff and clinical trial subjects were surveyed by questionnaire in this study. The results of interviews and questionnaire showed that coronavirus disease 2019 pandemic has led to many changes in the implementation of drug clinical trials, including: a variety of meetings being held online webinars using various platforms, telemedicine and follow-up by video, A large number of deviations from protocol and losses of follow-up, delivery of clinical trial drugs by express, additional workload caused by screening for coronavirus, and anxiety of subjects. These results suggest that the coronavirus disease 2019 outbreak has hindered the progress and damaged the quality of clinical trials. The online meeting, remote follow-up, express delivery of drugs and remote monitoring in the epidemic environment can ensure the progress of clinical trials to a certain extent, but they cannot fully guarantee the quality as before.
MeSH term(s)	Adult ; Antiviral Agents/therapeutic use ; Anxiety/etiology ; COVID-19/drug therapy ; COVID-19/epidemiology ; COVID-19/pathology ; COVID-19/virology ; Clinical Trials as Topic ; Humans ; Interviews as Topic ; Middle Aged ; Pandemics ; Patients/psychology ; Research Personnel/psychology ; SARS-CoV-2/isolation & purification ; Surveys and Questionnaires ; Telemedicine ; Young Adult
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-05-11
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0251410
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The effect of COVID-19 on surgical training.

Lund, Jon / Sadler, Paul / McLarty, Esther

Surgery (Oxford, Oxfordshire)

2021 Volume 39, Issue 12, Page(s) 829–833

Abstract: The COVID-19 pandemic has had a huge impact on society, healthcare in general and also on training ... simulation and conferencing platforms to finally be widely accepted and the importance of the wider surgical ... COVID ARCP outcomes have helped recognize the impact of the pandemic on progression and significant ...

Abstract	The COVID-19 pandemic has had a huge impact on society, healthcare in general and also on training in surgery. Cancellation of elective procedures, redeployment and establishment of green sites have combined with other factors to create significant gaps in training experience in operative and all other areas of surgery. There are nearly a million cases which have been lost to training since March 2020 and recovery means that tens of thousands of extra training cases have to be performed every month to recover that experience. There are pressures to address huge waiting list backlogs which may squeeze out time for training unless training is considered at the heart of any recovery plan. #NoTrainingTodayNoSurgeonsTomorrow. New, no blame, COVID ARCP outcomes have helped recognize the impact of the pandemic on progression and significant trainee and trainer organizations are united in raising the profile of the training crisis and offering a suite of suggestions on how to speed recovery. Disruption caused by the pandemic has allowed existing simulation and conferencing platforms to finally be widely accepted and the importance of the wider surgical team in supporting surgical training to be realized. New, outcomes-based curricula, with better feedback at their centre, will speed recovery of training trajectories. We should embrace the opportunity for change to help short and medium term recovery and improve the delivery of surgical training into the future.
Language	English
Publishing date	2021-09-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2180570-2
ISSN	1878-1764 ; 0263-9319
ISSN (online)	1878-1764
ISSN	0263-9319
DOI	10.1016/j.mpsur.2021.09.003
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Article ; Online: Mobilizing faith-based COVID-19 health ambassadors to address COVID-19 health disparities among African American older adults in under-resourced communities: A hybrid, community-based participatory intervention.

Adinkrah, Edward K / Bazargan, Shahrzad / Cobb, Sharon / Kibe, Lucy W / Vargas, Roberto / Waller, Joe / Sanchez, Humberto / Bazargan, Mohsen

PloS one

2024 Volume 19, Issue 2, Page(s) e0285963

Abstract: Introduction: The COVID-19 pandemic disproportionately affected older adults, particularly ... a faith-based lay health advisor model (COVID-19 Health Ambassador Program (CHAP)). We recruited COVID-19 ... medication-related challenges, encouraged COVID-19 vaccination, reduced psychological stress and addressed ...

Abstract	Introduction: The COVID-19 pandemic disproportionately affected older adults, particularly those with pre-existing chronic health conditions. To address the health disparity and challenges faced by under-resourced African American older adults in South Los Angeles during this period, we implemented a hybrid (virtual/in-person), pre-post, community-based participatory intervention research project utilizing a faith-based lay health advisor model (COVID-19 Health Ambassador Program (CHAP)). We recruited COVID-19 Health Ambassadors (CHAs) and African American older adults (participants) from faith-based organizations who partook in CHA-led meetings and follow-ups that educated and supported the participants. This paper seeks to evaluate this intervention's implementation using the Consolidated Framework for Implementation Research (CFIR) as a reporting tool with an emphasis on fidelity, challenges, and adaptations based on data collected via stakeholder interviews and surveys. Results: CHAP was delivered to 152 participants by 19 CHAs from 17 faith-based organizations. CHAs assisted with chronic disease management, resolved medication-related challenges, encouraged COVID-19 vaccination, reduced psychological stress and addressed healthcare avoidance behaviors such as COVID-19 vaccine hesitancy among the participants. Challenges encountered include ensuring participant engagement and retention in the virtual format and addressing technological barriers for CHAs and participants. Adaptations made to better suit the needs of participants included providing communication tools and additional training to CHAs to improve their proficiency in using virtual platforms in addition to adapting scientific/educational materials to suit our participants' diverse cultural and linguistic needs. Conclusion: The community-centered hybrid approach in addition to our partnership with faith-based organizations and their respective COVID-19 health ambassadors proved to be essential in assisting underserved African American older adults manage chronic health conditions and address community-wide health disparities during the COVID-19 pandemic. Adaptability, cultural sensitivity, and teamwork are key to implementing health interventions especially in underserved populations.
MeSH term(s)	Aged ; Humans ; Black or African American ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Health Inequities ; Pandemics ; Community-Based Participatory Research
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2024-02-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0285963
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Telerehabilitation for patients who have been hospitalised with covid-19: a qualitative study.

Killingback, Clare / Thompson, Mark / Nettleton, Marion / Hyde, Lucy / Marshall, Phil / Shepherdson, Joanne / Crooks, Michael G / Green, Angela / Simpson, Andrew J

Disability and rehabilitation

2023 Volume 46, Issue 1, Page(s) 150–158

Abstract: ... telerehabilitation programme as part of the Covid-19 journey; the telerehabilitation programme design and delivery ... based, supervised, telerehabilitation programme, following discharge from hospital with Covid-19 ... programme following Covid-19 after discharge from an acute hospital. Data were transcribed verbatim and ...

Abstract	Purpose: The aim of this qualitative study was to explore the views of participants of a group-based, supervised, telerehabilitation programme, following discharge from hospital with Covid-19. This study was part of a single-centre, fast-track (wait-list), randomised, mixed-methods, feasibility trial of telerehabilitation (Registration: Clinicaltrials.gov reference:285205). Methods: Semi-structured interviews were conducted over a virtual teleconference platform with 10 participants who took part in a telerehabilitation programme following Covid-19 after discharge from an acute hospital. Data were transcribed verbatim and analysed using thematic analysis. Results: Five themes were important from the participant perspective: telerehabilitation programme as part of the Covid-19 journey; the telerehabilitation programme design and delivery; peer aspects; the role of the instructor; and the role of technology and online delivery. Conclusions: Overall, the telerehabilitation programme was a positive experience for participants. The instructors were central to this positive view as was the group nature of the programme. The group aspect was particularly important in supporting the broader perceived wellbeing gains, such as the sense of enjoyment and reduced social isolation. Several participants would have liked to have continued with the exercises beyond the six-week intervention indicating that the programme could be a way to help people sustain a physically active lifestyle.IMPLICATIONS FOR REHABILITATIONParticipants who were recovering from Covid-19 following hospital admission perceived the telerehabilitation to be a positive experience overall.The group aspect of the telerehabilitation programme was important in supporting the broader perceived wellbeing gains such as the sense of enjoyment and reduced social isolation.Telerehabilitation programmes for Covid-19 may need to include pathways for participants to continue to engage in exercise beyond the time-limited six-week intervention to support ongoing self-management.
MeSH term(s)	Humans ; Telerehabilitation/methods ; COVID-19/epidemiology ; Exercise Therapy ; Qualitative Research ; Exercise
Language	English
Publishing date	2023-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1104775-6
ISSN	1464-5165 ; 0963-8288
ISSN (online)	1464-5165
ISSN	0963-8288
DOI	10.1080/09638288.2022.2159075
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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Impact of COVID-19 on distance learning practical design courses.

Fewella, Lina Nageb

International journal of technology and design education

2023 , Page(s) 1–24

Abstract: This paper explores the impact of COVID-19 on higher education practical design courses in Egypt ... during the COVID-19 pandemic. This paper examines strategies that are the most feasible for teaching ... practical courses during or after a pandemic through distance learning (on online platforms ...

Abstract	This paper explores the impact of COVID-19 on higher education practical design courses in Egypt. Because of inadequate resources and preparedness, Egyptian colleges have struggled to adopt digital teaching methods during the COVID-19 pandemic. This paper examines strategies that are the most feasible for teaching practical courses during or after a pandemic through distance learning (on online platforms). An action research project was set up to deliver two studio-based design courses, one on architectural drawing and the other on furniture design via distance learning (online mode). This approach used a suite of technologies and synchronous and asynchronous delivery mechanisms, such as Zoom and Google Classroom. Student perceptions about the impact of these changes were evaluated using questionnaires. A psychological effect of the conditions caused by the pandemic on students has been the loss of interest in academics. The research results partially support the use of online platforms to teach practical courses. However, more needs to be done to improve the delivery of online courses in Egypt. Further, holding competitions was found to boost students' motivation levels. A future strategy for teaching practical courses in applied arts and engineering is proposed in this paper.
Language	English
Publishing date	2023-01-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2016164-5
ISSN	1573-1804 ; 0957-7572
ISSN (online)	1573-1804
ISSN	0957-7572
DOI	10.1007/s10798-023-09806-0
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Article ; Online: The impact of COVID-19 on clinical research: the PIPPRA and MEDRA experience.

Larkin, Louise / Raad, Tala / Moses, Anusha / Fraser, Alexander / Gallagher, Stephen / Appel Esbensen, Bente / Glynn, Liam / Griffin, Anne / Tierney, Audrey C / Kennedy, Norelee

HRB open research

2023 Volume 4, Page(s) 55

Abstract: ... immunosuppressed and thus at a higher risk for COVID-19. The decision-making processes of both trials is outlined ... Both trials switched from a face-to-face delivery to a telehealth using online platforms. The PIPPRA study was ... Background: Coronavirus disease 2019 (COVID-19) has had a significant impact on clinical research ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) has had a significant impact on clinical research. This paper aims to provide an insight into how the COVID-19 pandemic, associated public health restrictions and international guidance on the conduct of clinical research impacted two clinical rheumatology research trials - the Physiotherapist-led Intervention to Promote Physical Activity in Rheumatoid Arthritis (PIPPRA) and the MEDiterranean diet in Rheumatoid Arthritis (MEDRA) projects. Methods: The March 2019 public health restrictions imposed to mitigate the risk of COVID-19 occurred at a time when PIPPRA was in the process of delivering assessment and intervention on a face-to-face basis (n=48) and MEDRA had commenced recruitment. Participants in PIPPRA and MEDRA had a diagnosis of rheumatoid arthritis, with some being immunosuppressed and thus at a higher risk for COVID-19. The decision-making processes of both trials is outlined to demonstrate the required amendments to continue in the context of the COVID-19 pandemic. Results: Amendments to PIPPRA and MEDRA trial protocols were agreed and received ethical and funder approval. Both trials switched from a face-to-face delivery to a telehealth using online platforms. The PIPPRA study was paused for five months (April-August 2020), resulting in n=33 (60%) negative deviations from assessment protocol. MEDRA switched from face-to-face to online recruitment with 20% (n=35/44) negative deviations in recruitment. Of the n=18 participants who consented to participating in a face-to-face trial, just n=2 (11%) opted to engage with telehealth delivery of the intervention. MEDRA assessment and intervention deviations were 100% as no sessions were completed as planned in 2020. Conclusions: The COVID-19 pandemic has severely impacted the PIPPRA and MEDRA clinical trials. Moving face-to-face clinical research to telehealth delivery may not be the panacea it is purported to be. Our experiences may be of benefit to researchers, clinicians, and funders in seeking to continue clinical research during a global pandemic.
Language	English
Publishing date	2023-11-10
Publishing country	Ireland
Document type	Journal Article
ISSN	2515-4826
ISSN (online)	2515-4826
DOI	10.12688/hrbopenres.13283.2
Database	MEDical Literature Analysis and Retrieval System OnLINE

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