Article ; Online: Systemic thrombosis in a large cohort of COVID-19 patients despite thromboprophylaxis: A retrospective study.
2021 Volume 199, Page(s) 132–142
Abstract: ... Methods: Single-cohort retrospective study of COVID-19 patients admitted, from March 3 to May 3 2020 ... Despite quasi-universal thromboprophylaxis, COVID-19 lead to a myriad of arterial and venous thrombotic ... patients, 80 thrombotic events were diagnosed in 69 patients (6.1% of the entire cohort). Forty-three ...
| Abstract | Background: Incidence of thrombotic events associated to Coronavirus disease-2019 (COVID-19) is difficult to assess and reported rates differ significantly. Optimal thromboprophylaxis is unclear. Objectives: We aimed to analyze the characteristics of patients with a confirmed thrombotic complication including inflammatory and hemostatic parameters, compare patients affected by arterial vs venous events and examine differences between survivors and non-survivors. We reviewed compliance with thromboprophylaxis and explored how the implementation of a severity-adjusted protocol could have influenced outcome. Methods: Single-cohort retrospective study of COVID-19 patients admitted, from March 3 to May 3 2020, to the Infanta Leonor University Hospital in Madrid, epicenter of the Spanish outbreak. Results: Among 1127 patients, 80 thrombotic events were diagnosed in 69 patients (6.1% of the entire cohort). Forty-three patients (62%) suffered venous thromboembolism, 18 (26%) arterial episodes and 6 (9%) concurrent venous and arterial thrombosis. Most patients (90%) with a confirmed thrombotic complication where under low-molecular-weight heparin treatment. Overt disseminated intravascular coagulation (DIC) was rare. Initial ISTH DIC score and pre-event CRP were significantly higher among non-survivors. In multivariate analysis, arterial localization was an independent predictor of mortality (OR = 18, 95% CI: 2.4-142, p < .05). Conclusions: Despite quasi-universal thromboprophylaxis, COVID-19 lead to a myriad of arterial and venous thrombotic events. Considering the subgroup of patients with thrombotic episodes, arterial events appeared earlier in the course of disease and conferred very poor prognosis, and an ISTH DIC score ≥ 3 at presentation was identified as a potential predictor of mortality. Severity-adjusted thromboprophylaxis seemed to decrease the number of events and could have influenced mortality. Randomized controlled trials are eagerly awaited. |
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| MeSH term(s) | Aged ; Aged, 80 and over ; Anticoagulants/therapeutic use ; COVID-19/complications ; Disseminated Intravascular Coagulation/diagnosis ; Disseminated Intravascular Coagulation/drug therapy ; Disseminated Intravascular Coagulation/etiology ; Female ; Heparin, Low-Molecular-Weight/therapeutic use ; Humans ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2/isolation & purification ; Thrombophilia/diagnosis ; Thrombophilia/drug therapy ; Thrombophilia/etiology ; Thrombosis/diagnosis ; Thrombosis/drug therapy ; Thrombosis/etiology ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/etiology | |||||
| Chemical Substances | Anticoagulants ; Heparin, Low-Molecular-Weight | |||||
| Language | English | |||||
| Publishing date | 2021-01-07 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 121852-9 | |||||
| ISSN | 1879-2472 ; 0049-3848 | |||||
| ISSN (online) | 1879-2472 | |||||
| ISSN | 0049-3848 | |||||
| DOI | 10.1016/j.thromres.2020.12.024 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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