Artikel ; Online: Association between HLA genotype and ferritin levels in COVID-19 infection: a study of a Saudi cohort.
Infectious diseases (London, England)
2021 Band 53, Heft 12, Seite(n) 891–899
Abstract: ... in COVID-19 infected patients. This study examined the association between patients' HLA genotype and serum ... ferritin levels are associated with an increase in COVID-19 severity, which may be affected by HLA ... ferritin level modulation and also assessed the effect of serum ferritin levels on infection severity ...
| Abstract | Background: An elevation in serum ferritin levels through an unknown mechanism was observed in COVID-19 infected patients. This study examined the association between patients' HLA genotype and serum ferritin level modulation and also assessed the effect of serum ferritin levels on infection severity/mortality. Materials and methods: One hundred and thirty-six COVID-19 Saudi patients were divided into two groups according to their ferritin levels: group 1 (<500 ng/mL, Results: High serum ferritin levels were associated with a significant increase in infection severity, as 75% of ICU patients showed high levels of ferritin compared to 43% of patients with moderate symptoms, Conclusion: High serum ferritin levels are associated with an increase in COVID-19 severity, which may be affected by HLA polymorphism. |
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| Mesh-Begriff(e) | COVID-19 ; Female ; Ferritins ; Genotype ; Humans ; Male ; SARS-CoV-2 ; Saudi Arabia/epidemiology | |||||
| Chemische Substanzen | Ferritins (9007-73-2) | |||||
| Sprache | Englisch | |||||
| Erscheinungsdatum | 2021-07-24 | |||||
| Erscheinungsland | England | |||||
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 2839775-7 | |||||
| ISSN | 2374-4243 ; 2374-4235 | |||||
| ISSN (online) | 2374-4243 | |||||
| ISSN | 2374-4235 | |||||
| DOI | 10.1080/23744235.2021.1955149 | |||||
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| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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