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  1. Article ; Online: Post-Acute COVID 19 Syndrome, 'Long COVID'.

    O'Keefe, Louise C

    Workplace health & safety

    2023  Volume 71, Issue 5, Page(s) 263

    MeSH term(s) Humans ; COVID-19 ; Post-Acute COVID-19 Syndrome
    Language English
    Publishing date 2023-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649181-3
    ISSN 2165-0969 ; 2165-0799
    ISSN (online) 2165-0969
    ISSN 2165-0799
    DOI 10.1177/21650799231164605
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  2. Article: Neutrophil Gelatinase-Associated Lipocalin as a Biomarker in Post-Acute COVID-19 Syndrome.

    Żmudka, Karol / Gałeczka-Turkiewicz, Alicja / Wroniecka, Aleksandra / Włosowicz, Aleksandra / Sobala-Szczygieł, Barbara / Mrochem-Kwarciak, Jolanta / Czuba, Zenon P / Jaroszewicz, Jerzy

    Journal of clinical medicine

    2024  Volume 13, Issue 7

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13071851
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  3. Article: Serum tryptase levels in patients with post-acute COVID-19 syndrome.

    Hadak, Ana / Premec, Durdica / Perkovic, Marina / Dolenec, Vanja / Bozan, Marina / Nedeljkovic, Vanja / Kelava, Tomislav / Markovic, Ivan

    Bratislavske lekarske listy

    2024  Volume 125, Issue 5, Page(s) 318–321

    Abstract: ... heterogeneous disorder (Tab. 2, Ref. 17). Text in PDF www.elis.sk Keywords: post Acute COVID-19 syndrome ... Objectives: to investigate the difference in serum tryptase levels between post-acute COVID-19 ... syndrome (PACS) patients and controls.: Background: PACS has been defined as symptoms that persist ...

    Abstract Objectives: to investigate the difference in serum tryptase levels between post-acute COVID-19 syndrome (PACS) patients and controls.
    Background: PACS has been defined as symptoms that persist for more than 3 months after the onset of COVID-19. The pathogenesis is still unknown, but mast cell activation has been proposed as one of the mechanisms, and increased serum tryptase levels have been demonstrated in PACS patients.
    Methods: A total number of 133 patients were included: 50 with PACS, 37 asymptomatic COVID-19 convalescents, and 46 controls with a negative history of COVID-19. Serum tryptase levels were determined in all participants.
    Results: There was no significant difference in serum levels of tryptase among the groups.
    Conclusion: the role of mast cell activation in PACS remains unclear and further research is needed to fill the gaps in understanding the pathogenesis of this complex and heterogeneous disorder (Tab. 2, Ref. 17). Text in PDF www.elis.sk Keywords: post Acute COVID-19 syndrome, tryptase, mast cells, lactate dehydrogenase, ferritin.
    MeSH term(s) Humans ; Tryptases ; Post-Acute COVID-19 Syndrome ; COVID-19 ; Mast Cells
    Chemical Substances Tryptases (EC 3.4.21.59)
    Language English
    Publishing date 2024-01-12
    Publishing country Slovakia
    Document type Journal Article
    ZDB-ID 127421-1
    ISSN 0006-9248
    ISSN 0006-9248
    DOI 10.4149/BLL_2024_47
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  4. Article ; Online: The gut microbiome associates with phenotypic manifestations of post-acute COVID-19 syndrome.

    Su, Qi / Lau, Raphaela I / Liu, Qin / Li, Moses K T / Yan Mak, Joyce Wing / Lu, Wenqi / Lau, Ivan S F / Lau, Louis H S / Yeung, Giann T Y / Cheung, Chun Pan / Tang, Whitney / Liu, Chengyu / Ching, Jessica Y L / Cheong, Pui Kuan / Chan, Francis K L / Ng, Siew C

    Cell host & microbe

    2024  Volume 32, Issue 5, Page(s) 651–660.e4

    Abstract: The mechanisms underlying the many phenotypic manifestations of post-acute COVID-19 syndrome (PACS ... specific symptoms. Our processed data covered 585 bacterial species and 500 microbial pathways, explaining ... showed an accuracy of 0.89 in predicting individual symptoms of PACS in the test set and maintained ...

    Abstract The mechanisms underlying the many phenotypic manifestations of post-acute COVID-19 syndrome (PACS) are poorly understood. Herein, we characterized the gut microbiome in heterogeneous cohorts of subjects with PACS and developed a multi-label machine learning model for using the microbiome to predict specific symptoms. Our processed data covered 585 bacterial species and 500 microbial pathways, explaining 12.7% of the inter-individual variability in PACS. Three gut-microbiome-based enterotypes were identified in subjects with PACS and associated with different phenotypic manifestations. The trained model showed an accuracy of 0.89 in predicting individual symptoms of PACS in the test set and maintained a sensitivity of 86% and a specificity of 82% in predicting upcoming symptoms in an independent longitudinal cohort of subjects before they developed PACS. This study demonstrates that the gut microbiome is associated with phenotypic manifestations of PACS, which has potential clinical utility for the prediction and diagnosis of PACS.
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; COVID-19/microbiology ; Post-Acute COVID-19 Syndrome ; Male ; Phenotype ; Female ; Machine Learning ; SARS-CoV-2 ; Middle Aged ; Adult ; Bacteria/classification ; Bacteria/isolation & purification ; Bacteria/genetics ; Aged ; Feces/microbiology ; Feces/virology ; Cohort Studies ; Longitudinal Studies
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2024.04.005
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  5. Article ; Online: Post-acute COVID-19 syndrome.

    Montani, David / Savale, Laurent / Noel, Nicolas / Meyrignac, Olivier / Colle, Romain / Gasnier, Matthieu / Corruble, Emmanuelle / Beurnier, Antoine / Jutant, Etienne-Marie / Pham, Tài / Lecoq, Anne-Lise / Papon, Jean-François / Figueiredo, Samy / Harrois, Anatole / Humbert, Marc / Monnet, Xavier

    European respiratory review : an official journal of the European Respiratory Society

    2022  Volume 31, Issue 163

    Abstract: ... acute COVID-19 syndrome". Most studies have focused on patients hospitalised for severe COVID-19 ... but acute COVID-19 syndrome is not restricted to these patients and exists in outpatients ... evolution of respiratory complications and other organ-related injuries associated with post-acute COVID-19 ...

    Abstract Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic that has resulted in millions of deaths and a major strain on health systems worldwide. Medical treatments for COVID-19 (anticoagulants, corticosteroids, anti-inflammatory drugs, oxygenation therapy and ventilation) and vaccination have improved patient outcomes. The majority of patients will recover spontaneously or after acute-phase management, but clinicians are now faced with long-term complications of COVID-19 including a large variety of symptoms, defined as "post-acute COVID-19 syndrome". Most studies have focused on patients hospitalised for severe COVID-19, but acute COVID-19 syndrome is not restricted to these patients and exists in outpatients. Given the diversity of symptoms and the high prevalence of persistent symptoms, the management of these patients requires a multidisciplinary team approach, which will result in the consumption of large amounts of health resources in the coming months. In this review, we discuss the presentation, prevalence, pathophysiology and evolution of respiratory complications and other organ-related injuries associated with post-acute COVID-19 syndrome.
    MeSH term(s) COVID-19/complications ; Humans ; Lung ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0185-2021
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  6. Article ; Online: Post-acute COVID-19 syndrome in previously hospitalized patients.

    Eo, Yoonsoo / Chang, Sun Ju

    Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing

    2024  

    Abstract: ... sequelae after COVID-19 infection, also known as post-acute COVID-19 syndrome (PCS). The aims of this study ... distress of symptoms shed light on the identification of post-COVID symptoms in detail. To objectively ... Introduction: With the prolongation of the COVID-19 pandemic, more individuals are experiencing ...

    Abstract Introduction: With the prolongation of the COVID-19 pandemic, more individuals are experiencing sequelae after COVID-19 infection, also known as post-acute COVID-19 syndrome (PCS). The aims of this study were to describe the prevalence and characteristics of PCS symptoms such as fatigue, anxiety, and depression and to compare these symptoms according to participant characteristics in patients who had been previously hospitalized due to COVID-19.
    Design: A descriptive cross-sectional study design was used.
    Methods: We included 114 individuals who had been hospitalized for COVID-19 and were discharged from the hospital at least 4 weeks before. Symptoms were assessed using the Fatigue Severity Scale, the Hospital Anxiety-Depression Scale, and the PCS symptom questionnaire developed by the authors. We used descriptive statistics, the Student's t-test, the Wilcoxon rank-sum test, and the Kruskal-Wallis test for statistical analyses.
    Results: The most prevalent symptoms were anxiety (66.7%), fatigue (64.0%), headache (57.9%), and concentration or memory difficulties (57.9%). Concentration or memory difficulties and sleep disturbances had the highest mean frequency. Concentration or memory difficulties were rated with the highest mean severity, and cough, loss of taste, and muscle and joint pain had the highest mean distress scores. Female participants, individuals hospitalized for more than 2 weeks, individuals discharged more than 9 months ago, unvaccinated patients, and those who tried at least one symptom relief method reported higher symptom distress.
    Conclusion: The findings of this investigation into the frequency, severity, and distress of symptoms shed light on the identification of post-COVID symptoms in detail. To objectively evaluate and comprehend the symptom trajectories of PCS, prospective studies about the development of symptom assessment tools and studies with a longitudinal design should be conducted.
    Clinical relevance: A substantial number of respondents reported numerous symptoms and expressed symptom distress; therefore, the development of nursing interventions and treatments to alleviate PCS symptoms is crucial.
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2008214-9
    ISSN 1547-5069 ; 1527-6546
    ISSN (online) 1547-5069
    ISSN 1527-6546
    DOI 10.1111/jnu.12967
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  7. Article ; Online: Sicca symptoms in post-acute COVID-19 syndrome.

    Melo, Thayanara Silva / Beltrão, Renata Cristina / Mendonça, Andréia de Fátima Trindade de / Duarte, Ângela Luzia Branco Pinto / Gueiros, Luiz Alcino

    Oral diseases

    2022  Volume 28 Suppl 2, Page(s) 2620–2621

    MeSH term(s) Humans ; COVID-19 ; Sjogren's Syndrome/complications ; Sjogren's Syndrome/diagnosis ; Arthritis, Rheumatoid
    Language English
    Publishing date 2022-02-23
    Publishing country Denmark
    Document type Letter
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.14159
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  8. Article ; Online: Gastrointestinal post-acute COVID-19 syndrome.

    Meringer, Hadar / Mehandru, Saurabh

    Nature reviews. Gastroenterology & hepatology

    2022  Volume 19, Issue 6, Page(s) 345–346

    MeSH term(s) COVID-19/complications ; Gastrointestinal Tract ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-04-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-022-00611-z
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  9. Article ; Online: The Clinical Impact of Cardiovascular Symptoms on Post-Acute COVID-19 Syndrome.

    Dutra, Giovanni Possamai / Gomes, Bruno Ferraz de Oliveira

    Arquivos brasileiros de cardiologia

    2023  Volume 120, Issue 5, Page(s) e20230282

    Title translation O Impacto Clínico dos Sintomas Cardiovasculares na Síndrome Pós-Aguda de COVID-19.
    MeSH term(s) Humans ; Post-Acute COVID-19 Syndrome ; COVID-19/complications ; Heart Diseases ; Vascular Diseases
    Language Portuguese
    Publishing date 2023-07-04
    Publishing country Brazil
    Document type Editorial ; Comment
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.36660/abc.20230282
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  10. Article ; Online: Gut Microbiome Composition and Dynamics in Hospitalized COVID-19 Patients and Patients with Post-Acute COVID-19 Syndrome.

    Brīvība, Monta / Silamiķele, Laila / Birzniece, Līga / Ansone, Laura / Megnis, Kaspars / Silamiķelis, Ivars / Pelcmane, Līva / Borisova, Daniella / Rozenberga, Maija / Jagare, Lauma / Elbere, Ilze / Kloviņš, Jānis

    International journal of molecular sciences

    2024  Volume 25, Issue 1

    Abstract: ... on the emergence of post-COVID-19 conditions. Involving 146 COVID-19 patients and 110 healthy controls, this study ... 19). We aimed to investigate the dynamics and compositional changes in the gut microbiome of COVID-19 ... month follow-ups. We observed a decline in taxonomic diversity among hospitalized COVID-19 patients ...

    Abstract The gut microbiome plays a pivotal role in the modulation of host responses during viral infections, and recent studies have underscored its significance in the context of coronavirus disease 2019 (COVID-19). We aimed to investigate the dynamics and compositional changes in the gut microbiome of COVID-19 patients, addressing both the acute phase and the recovery process, with a particular focus on the emergence of post-COVID-19 conditions. Involving 146 COVID-19 patients and 110 healthy controls, this study employed a shotgun metagenomics approach for cross-sectional and longitudinal analyses with one- and three-month follow-ups. We observed a decline in taxonomic diversity among hospitalized COVID-19 patients compared to healthy controls, while a subsequent increase in alpha diversity was shown during the recovery process. A notable contribution of
    MeSH term(s) Humans ; COVID-19 ; Gastrointestinal Microbiome ; Cross-Sectional Studies ; Post-Acute COVID-19 Syndrome ; Patients ; Clostridiales
    Language English
    Publishing date 2024-01-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25010567
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