Artikel ; Online: Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19.
2021 Band 36, Heft 3, Seite(n) 109414
Abstract: ... numbers of SARS-CoV-2-specific T cells capable of homeostatic proliferation. In contrast, fatal COVID-19 ... immunity, little is known about the phenotypic features of SARS-CoV-2-specific T cells associated ... with recovery from severe coronavirus disease 2019 (COVID-19). We analyze T cells from 34 individuals with COVID ...
| Abstract | Although T cells are likely players in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity, little is known about the phenotypic features of SARS-CoV-2-specific T cells associated with recovery from severe coronavirus disease 2019 (COVID-19). We analyze T cells from 34 individuals with COVID-19 with severity ranging from mild (outpatient) to critical, culminating in death. Relative to individuals who succumbed, individuals who recovered from severe COVID-19 harbor elevated and increasing numbers of SARS-CoV-2-specific T cells capable of homeostatic proliferation. In contrast, fatal COVID-19 cases display elevated numbers of SARS-CoV-2-specific regulatory T cells and a time-dependent escalation in activated bystander CXCR4 |
|---|---|
| Sprache | Englisch |
| Erscheinungsdatum | 2021-06-29 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2649101-1 |
| ISSN | 2211-1247 ; 2211-1247 |
| ISSN (online) | 2211-1247 |
| ISSN | 2211-1247 |
| DOI | 10.1016/j.celrep.2021.109414 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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