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  1. Article ; Online: Testosterone in COVID-19: Friend or Foe?

    Niemann, Peter J / Goldstein, Heidi V

    Endocrine

    2021  Volume 71, Issue 2, Page(s) 281–282

    MeSH term(s) COVID-19/blood ; Humans ; Male ; Risk Factors ; Testosterone/blood
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2021-01-25
    Publishing country United States
    Document type Letter
    ZDB-ID 1194484-5
    ISSN 1559-0100 ; 1355-008X ; 0969-711X
    ISSN (online) 1559-0100
    ISSN 1355-008X ; 0969-711X
    DOI 10.1007/s12020-021-02623-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3884: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Testosterone in COVID-19 - Foe, Friend or Fatal Victim?

    Kalra, Sanjay / Bhattacharya, Saptarshi / Kalhan, Atul

    European endocrinology

    2020  Volume 16, Issue 2, Page(s) 88–91

    Abstract: ... with low testosterone levels being either a surrogate marker of a poor metabolic state or playing a more ... to be risk factors associated with an increased COVID-19-related case fatality. The precise ... of androgens in transcription of transmembrane protease serine-2, which facilitates COVID-19 anchoring ...

    Abstract The evidence derived from observational studies suggests male gender, diabetes and central obesity to be risk factors associated with an increased COVID-19-related case fatality. The precise pathophysiology behind this gender difference in mortality outcomes remains unclear at this stage, although it is worth exploring a possible role of testosterone as one of the contributory factors. The observed role of androgens in transcription of transmembrane protease serine-2, which facilitates COVID-19 anchoring to angiotensin-converting enzyme 2 cell surface receptors, seems to suggest that higher testosterone levels might be detrimental for outcomes. On the other hand, men with type 2 diabetes mellitus and central obesity have an increased prevalence of hypogonadotropic hypogonadism, with inhibition of gonadotropin-releasing hormone secretion induced by inflammatory cytokines being one of the postulated mechanisms. The increased COVID-19 case fatality in this cohort might perhaps reflect an underlying pro-inflammatory state, with low testosterone levels being either a surrogate marker of a poor metabolic state or playing a more active role in propagation of inflammation and thrombosis.
    Keywords covid19
    Language English
    Publishing date 2020-10-06
    Publishing country England
    Document type Editorial
    ISSN 1758-3780
    ISSN (online) 1758-3780
    DOI 10.17925/EE.2020.16.2.88
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  3. Article: Testosterone in COVID-19 - foe, friend or fatal victim?

    Kalra, S. / Bhattacharya, S. / Kalhan, A.

    European Endocrinology

    Abstract: ... with low testosterone levels being either a surrogate marker of a poor metabolic state or playing a more ... to be risk factors associated with an increased COVID-19-related case fatality The precise ... of androgens in transcription of transmembrane protease serine-2, which facilitates COVID-19 anchoring ...

    Abstract The evidence derived from observational studies suggests male gender, diabetes and central obesity to be risk factors associated with an increased COVID-19-related case fatality The precise pathophysiology behind this gender difference in mortality outcomes remains unclear at this stage, although it is worth exploring a possible role of testosterone as one of the contributory factors The observed role of androgens in transcription of transmembrane protease serine-2, which facilitates COVID-19 anchoring to angiotensin-converting enzyme 2 cell surface receptors, seems to suggest that higher testosterone levels might be detrimental for outcomes On the other hand, men with type 2 diabetes mellitus and central obesity have an increased prevalence of hypogonadotropic hypogonadism, with inhibition of gonadotropin-releasing hormone secretion induced by inflammatory cytokines being one of the postulated mechanisms The increased COVID-19 case fatality in this cohort might perhaps reflect an underlying pro-inflammatory state, with low testosterone levels being either a surrogate marker of a poor metabolic state or playing a more active role in propagation of inflammation and thrombosis
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #875011
    Database COVID19

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