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  1. Book ; Thesis: Die Rolle von Beta-Interferon und der zelltypspezifischen Aktivierung des Typ I Interferon-Signalweges in der Pathogenese der murinen Theilervirus-Enzephalomyelitis

    Bühler, Melanie

    2021  

    Author's details vorgelegt von Melanie Bühler
    Language German
    Size 167 Seiten, Illustrationen, Diagramme
    Publisher DVG Service GmbH
    Publishing place Gießen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Gießen, 2021
    HBZ-ID HT021011278
    ISBN 978-3-86345-576-7 ; 9783863455736 ; 3-86345-576-2 ; 3863455738
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 A 961 available for loan (reading room) Lesesaal EG

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  2. Book ; Thesis: Typ I Interferon-Antworten in naiven B-Zellen von Patienten mit variablem Immundefekt

    Kanne, Christian

    2020  

    Author's details vorgelegt von Christian Friedrich Heinrich Kanne
    Language German
    Size 102 Seiten, Diagramme, 30 cm
    Publishing place Freiburg im Breisgau
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Albert-Ludwigs-Universität Freiburg im Breisgau, 2020
    HBZ-ID HT020624928
    Database Catalogue ZB MED Medicine, Health

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    2020 E 1459 order for loan Magazin

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  3. Article ; Online: A Single-Atom Manganese Nanozyme Mn-N/C Promotes Anti-Tumor Immune Response via Eliciting Type I Interferon Signaling.

    Qiao, Wen / Chen, Jingqi / Zhou, Huayuan / Hu, Cegui / Dalangood, Sumiya / Li, Hanjun / Yang, Dandan / Yang, Yu / Gui, Jun

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  Volume 11, Issue 14, Page(s) e2305979

    Abstract: ... are a new type of nanozyme with incredible catalytic efficiency. Here, a single-atom manganese (Mn)-N ...

    Abstract Tumor microenvironment (TME)-induced nanocatalytic therapy is a promising strategy for cancer treatment, but the low catalytic efficiency limits its therapeutic efficacy. Single-atom catalysts (SACs) are a new type of nanozyme with incredible catalytic efficiency. Here, a single-atom manganese (Mn)-N/C nanozyme is constructed. Mn-N/C catalyzes the conversion of cellular H
    MeSH term(s) Humans ; Manganese ; Hydrogen Peroxide ; Signal Transduction ; Neoplasms/drug therapy ; Interferon Type I ; Immunity ; Tumor Microenvironment
    Chemical Substances Manganese (42Z2K6ZL8P) ; Hydrogen Peroxide (BBX060AN9V) ; Interferon Type I
    Language English
    Publishing date 2024-02-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202305979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Type I interferon activation in RAS-associated autoimmune leukoproliferative disease (RALD).

    Papa, Riccardo / Rusmini, Marta / Schena, Francesca / Traggiai, Elisabetta / Coccia, Maria Cristina / Caorsi, Roberta / Arrigo, Serena / Pasetti, Francesco / Signa, Sara / Barone, Patrizia / Santamaria, Giuseppe / Spirito, Giovanni / Sanges, Remo / Vozzi, Diego / Cavalli, Andrea / Gustincich, Stefano / Ravelli, Angelo / Gattorno, Marco / Ceccherini, Isabella /
    Volpi, Stefano

    Clinical immunology (Orlando, Fla.)

    2021  Volume 231, Page(s) 108837

    Abstract: ... of type I interferon pathway was observed in peripheral blood. Since 18 years of age, the patient ... dysregulation and type I interferon activation. ...

    Abstract RAS-associated autoimmune leukoproliferative disease (RALD) is a rare immune dysregulation syndrome caused by somatic gain-of-function mutations of either NRAS or KRAS gene in hematopoietic cells. We describe a 27-year-old patient presenting at 5 months of age with recurrent infections and generalized lymphadenopathy who developed a complex multi-organ autoimmune syndrome with hypogammaglobulinemia, partially controlled with oral steroids, hydroxichloroquine, mofetil mycophenolate and IVIG prophylaxis. Activation of type I interferon pathway was observed in peripheral blood. Since 18 years of age, the patient developed regenerative nodular hyperplasia of the liver evolving into hepatopulmonary syndrome. Whole exome sequencing analysis of the peripheral blood DNA showed the NRAS p.Gly13Asp mutation validated as somatic. Our report highlights the possibility of detecting somatic NRAS gene mutations in patients with inflammatory immune dysregulation and type I interferon activation.
    MeSH term(s) Adult ; Autoimmune Lymphoproliferative Syndrome/complications ; Autoimmune Lymphoproliferative Syndrome/genetics ; Autoimmune Lymphoproliferative Syndrome/immunology ; GTP Phosphohydrolases/genetics ; Humans ; Interferon Type I/immunology ; Liver Diseases/genetics ; Liver Diseases/immunology ; Membrane Proteins/genetics ; Mutation
    Chemical Substances Interferon Type I ; Membrane Proteins ; GTP Phosphohydrolases (EC 3.6.1.-) ; NRAS protein, human (EC 3.6.1.-)
    Language English
    Publishing date 2021-08-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1459903-x
    ISSN 1521-7035 ; 1521-6616
    ISSN (online) 1521-7035
    ISSN 1521-6616
    DOI 10.1016/j.clim.2021.108837
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 880: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Type I interferon dysregulation in Systemic Sclerosis.

    Skaug, Brian / Assassi, Shervin

    Cytokine

    2019  Volume 132, Page(s) 154635

    Abstract: ... Type I interferons (IFNs), a family of cytokines with essential roles in the immune response ... in this edition). Polymorphisms in interferon-regulatory factors confer an increased risk of SSc, and IFN excess ... of Type I IFN dysregulation in SSc, revealed predominately by genetics and gene expression profiling ...

    Abstract Systemic Sclerosis (Scleroderma, SSc) is a multifaceted disease characterized by autoimmunity, vasculopathy, and fibrosis affecting the skin and internal organs. Despite advances in the understanding and treatment of SSc in recent years, SSc continues to cause reduced quality of life and premature mortality. Type I interferons (IFNs), a family of cytokines with essential roles in the immune response to microbial infection, play a pathogenic role in certain autoimmune diseases (reviewed elsewhere in this edition). Polymorphisms in interferon-regulatory factors confer an increased risk of SSc, and IFN excess is evident in the blood and skin of a large percentage of SSc patients. Here we describe the evidence of Type I IFN dysregulation in SSc, revealed predominately by genetics and gene expression profiling. We also discuss evidence regarding mechanisms by which Type I IFN might contribute to SSc pathogenesis, mechanisms driving excess Type I IFN production in SSc, and the potential roles of Type I IFNs as biomarkers and therapeutic targets in SSc.
    Language English
    Publishing date 2019-01-23
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1018055-2
    ISSN 1096-0023 ; 1043-4666
    ISSN (online) 1096-0023
    ISSN 1043-4666
    DOI 10.1016/j.cyto.2018.12.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2840: Show issues Location:
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  6. Article ; Conference proceedings: Steuerung der Typ I Interferon Antwort durch den cGAS-STING Signalweg und das NLRP3 Inflammasom bei Tuberkulose

    Gottschalk, C / Theobald, S / Lange, D / Keck, K / Rybniker, J

    Pneumologie

    2024  Volume 78, Issue S 01

    Event/congress 64. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e. V., Mannheim, 2024-03-20
    Language German
    Publishing date 2024-03-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/s-0044-1778799
    Database Thieme publisher's database

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    Uh II Zs.142: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 54: Show issues

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  7. Article ; Online: RelB suppresses type I Interferon signaling in dendritic cells.

    Saha, Irene / Jaiswal, Hemant / Mishra, Richa / Nel, Hendrik J / Schreuder, Jaring / Kaushik, Monika / Singh Chauhan, Kuldeep / Singh Rawat, Bhupendra / Thomas, Ranjeny / Naik, Shalin / Kumar, Himanshu / Tailor, Prafullakumar

    Cellular immunology

    2020  Volume 349, Page(s) 104043

    Abstract: Type I Interferon (IFN) signaling plays a critical role in dendritic cell (DC) development and ... functions. Inhibition of hyper type I IFN signaling promotes cDC2 subtype development. Relb is essential ... to development of cDC2 subtype and here we analyzed its effect on type I IFN signaling in DCs. We show that Relb ...

    Abstract Type I Interferon (IFN) signaling plays a critical role in dendritic cell (DC) development and functions. Inhibition of hyper type I IFN signaling promotes cDC2 subtype development. Relb is essential to development of cDC2 subtype and here we analyzed its effect on type I IFN signaling in DCs. We show that Relb suppresses the homeostatic type I IFN signaling in cDC2 cultures. TLR stimulation of FL-DCs led to RelB induction coinciding with fall in IFN signatures; conforming with the observation Relb expression reduced TLR stimulated IFN induction along with decrease in ISGs. Towards understanding mechanism, we show that effects of RelB are mediated by increased levels of IκBα. We demonstrate that RelB dampened antiviral responses by lowering ISG levels and the defect in cDC2 development in RelB null mice can be rescued in Ifnar1
    MeSH term(s) Amino Acid Sequence ; Animals ; Cell Differentiation ; Cells, Cultured ; Crosses, Genetic ; Dendritic Cells/classification ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Gene Expression Regulation/immunology ; Interferon Type I/immunology ; Mice ; NF-KappaB Inhibitor alpha/physiology ; NIH 3T3 Cells ; Newcastle disease virus/immunology ; Peptides/pharmacology ; Receptor, Interferon alpha-beta/deficiency ; Receptor, Interferon alpha-beta/genetics ; Receptor, Interferon alpha-beta/physiology ; Signal Transduction/immunology ; Spleen/cytology ; Transcription Factor RelB/deficiency ; Transcription Factor RelB/genetics ; Transcription Factor RelB/physiology ; Viral Load
    Chemical Substances Ifnar1 protein, mouse ; Interferon Type I ; Peptides ; Relb protein, mouse ; SN52 peptide ; NF-KappaB Inhibitor alpha (139874-52-5) ; Transcription Factor RelB (147337-75-5) ; Receptor, Interferon alpha-beta (156986-95-7)
    Language English
    Publishing date 2020-01-27
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80094-6
    ISSN 1090-2163 ; 0008-8749
    ISSN (online) 1090-2163
    ISSN 0008-8749
    DOI 10.1016/j.cellimm.2020.104043
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 417: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Book ; Thesis: Type-I interferon signaling in the regulation of monocyte and macrophage responses during infection in patients with decompensated cirrhosis

    Rooney, Michael / Bruns, Tony / Bauer, Michael / Trebicka, Jonel

    2023  

    Institution Friedrich-Schiller-Universität Jena
    Author's details by M.Sc. Michael Rooney
    Language English
    Size 141 Seiten, Illustrationen, Diagramme, 30 cm
    Publishing place Jena
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Friedrich-Schiller-Universität Jena, 2023
    Note Tag der Verteidigung: 18.04.2023
    HBZ-ID HT030351990
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 1249 order for loan Magazin

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  9. Book ; Thesis: Regulation der induzierbaren Stickstoffmonoxidsynthase durch Typ I Interferon

    Mattner, Jochen

    2002  

    Author's details vorgelegt von Jochen Mattner
    Language German
    Size 92 Bl., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 2002
    HBZ-ID HT013323879
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 E 1147 order for loan Magazin

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  10. Article ; Online: Type I Interferon in Malaria: A Balancing Act.

    Mooney, Jason Paul / Wassmer, Samuel Crocodile / Hafalla, Julius Clemence

    Trends in parasitology

    2017  Volume 33, Issue 4, Page(s) 257–260

    Abstract: Type I interferons (IFN-Is) can now be considered as the wedge that balances clinical protection ... network leading to the dampening of proinflammatory responses, expansion of type 1 regulatory (Tr1) cells ...

    Abstract Type I interferons (IFN-Is) can now be considered as the wedge that balances clinical protection to malaria. New studies recently highlighted a central role for IFN-Is in orchestrating an immunoregulatory network leading to the dampening of proinflammatory responses, expansion of type 1 regulatory (Tr1) cells, and restriction of humoral immunity during malaria blood stage infection. Plasmacytoid dendritic cells (pDCs) were identified as the major source of IFN-Is. Here, we integrate the findings and provide a model for the mechanisms involved.
    MeSH term(s) Animals ; Cell Proliferation ; Dendritic Cells/immunology ; Humans ; Immunity, Humoral/immunology ; Interferon Type I/metabolism ; Malaria/immunology ; Models, Biological ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Interferon Type I
    Language English
    Publishing date 2017-01-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2036227-4
    ISSN 1471-5007 ; 1471-4922
    ISSN (online) 1471-5007
    ISSN 1471-4922
    DOI 10.1016/j.pt.2016.12.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2898: Show issues Location:
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    Zs.MG 16: Show issues
    Zs.MO 251: Show issues

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