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  1. Article ; Online: Covid-19 in end-stage renal disease patients with renal replacement therapies: A systematic review and meta-analysis.

    Nopsopon, Tanawin / Kittrakulrat, Jathurong / Takkavatakarn, Kullaya / Eiamsitrakoon, Thanee / Kanjanabuch, Talerngsak / Pongpirul, Krit

    PLoS neglected tropical diseases

    2021  Volume 15, Issue 6, Page(s) e0009156

    Abstract: ... End-stage renal disease (ESRD) patients with renal replacement therapy (RRT) might have a higher prevalence and CFR due ... This meta-analysis suggested high COVID-19 prevalence and CFR in ESRD patients with RRT. ESRD patients with RRT ... meta-analysis up to June 30, 2020, to evaluate the prevalence and case fatality rate (CFR) of the COVID-19 ...

    Abstract Background: The novel coronavirus (COVID-19), caused by SARS-CoV-2, showed various prevalence and case-fatality rates (CFR) among patients with different pre-existing chronic conditions. End-stage renal disease (ESRD) patients with renal replacement therapy (RRT) might have a higher prevalence and CFR due to reduced immune function from uremia and kidney tropism of SARS-CoV-2, but there was a lack of systematic study on the infection and mortality of the SARS-CoV-2 infection in ESRD patients with various RRT.
    Methodology/principal findings: We searched five electronic databases and performed a systematic review and meta-analysis up to June 30, 2020, to evaluate the prevalence and case fatality rate (CFR) of the COVID-19 infection among ESRD patients with RRT. The global COVID-19 data were retrieved from the international database on June 30, 2020, for estimating the prevalence and CFR of the general population as referencing points. Of 3,272 potential studies, 34 were eligible studies consisted of 1,944 COVID-19 confirmed cases in 21,873 ESRD patients with RRT from 12 countries in four WHO regions. The overall pooled prevalence in ESRD patients with RRT was 3.10% [95% confidence interval (CI) 1.25-5.72] which was higher than referencing 0.14% global average prevalence. The overall estimated CFR of COVID-19 in ESRD patients with RRT was 18.06% (95% CI 14.09-22.32) which was higher than the global average at 4.98%.
    Conclusions: This meta-analysis suggested high COVID-19 prevalence and CFR in ESRD patients with RRT. ESRD patients with RRT should have their specific protocol of COVID-19 prevention and treatment to mitigate excess cases and deaths.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/prevention & control ; Humans ; Intensive Care Units ; Kidney Failure, Chronic/therapy ; Prevalence ; Renal Replacement Therapy ; Respiration, Artificial ; SARS-CoV-2
    Language English
    Publishing date 2021-06-15
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0009156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Covid-19 in end-stage renal disease patients with renal replacement therapies: a systematic review and meta-analysis

    Nopsopon, Tanawin / Kittrakulrat, Jathurong / Takkavatakarn, Kullaya / Eiamsitrakoon, Thanee / Kanjanabuch, Talerngsak / Pongpirul, Krit

    medRxiv

    Abstract: ... End-stage renal disease (ESRD) patients with renal replacement therapy (RRT) might have a higher prevalence and CFR due ... five electronic databases and performed a systematic review and meta-analysis up to June 30, 2020 ... to evaluate the prevalence and case fatality rate (CFR) of the COVID-19 infection among ESRD patients with RRT ...

    Abstract Introduction The novel coronavirus (COVID-19), caused by SARS-CoV-2, showed various prevalence and case-fatality rates (CFR) among patients with differentpre-existing chronic conditions. End-stage renal disease (ESRD) patients with renal replacement therapy (RRT) might have a higher prevalence and CFR due to reduced immune function from uremia and kidney tropism of SARS-CoV-2, but there was no systematic study on the infection and mortality of the SARS-CoV-2 infection in ESRD patients who are on RRT. Methods We searched five electronic databases and performed a systematic review and meta-analysis up to June 30, 2020, to evaluate the prevalence and case fatality rate (CFR) of the COVID-19 infection among ESRD patients with RRT. The global COVID-19 data were retrieved from the international database on June 30, 2020, for estimating the prevalence and CFR of the general population as referencing points. Results Of 3,272 potential studies, 34 were eligible studies consisted of 1,944 COVID-19 confirmed cases in 21,873 ESRD patients with RRT from 12 countries in four WHO regions. The overall pooled prevalence in ESRD patients with RRT was 3.10% [95% confidence interval (CI) 1.25-5.72] which was higher than referencing 0.14% global average prevalence. The overall estimated CFR of COVID-19 in ESRD patients with RRT was 18.06% (95% CI 14.09-22.32) which was higher than the global average at 4.98%. Conclusions This meta-analysis suggested high COVID-19 prevalence and CFR in ESRD patients with RRT. ESRD patients with RRT should have their specific protocol of COVID-19 prevention and treatment to mitigate excess cases and deaths.
    Keywords covid19
    Language English
    Publishing date 2021-01-26
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.01.25.21250454
    Database COVID19

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  3. Book ; Online: Renal Complications in COVID-19

    Kunutsor, SK / Laukkanen, JA

    A Systematic Review and Meta-Analysis

    2020  

    Abstract: ... renal complications in COVID-19 patients were sought from MEDLINE, Embase and the Cochrane Library ... of COVID-19 and their incidence using a systematic meta-analysis. Design Observational studies reporting ... Conclusions Frequent renal complications reported among hospitalized COVID-19 patients are electrolyte ...

    Abstract Purpose Emerging data suggest that coronavirus disease 2019 (COVID-19) has extrapulmonary manifestations but its renal manifestations are not clearly defined. We aimed to evaluate renal complications of COVID-19 and their incidence using a systematic meta-analysis. Design Observational studies reporting renal complications in COVID-19 patients were sought from MEDLINE, Embase and the Cochrane Library from 2019 to June 2020. The nine-star Newcastle-Ottawa Scale was used to evaluate methodological quality. Incidence with 95% confidence intervals (CIs) were pooled using random-effects models. Results We included 22 observational cohort studies comprising of 17,391 COVID-19 patients. Quality scores of studies ranged from 4 to 6. The pooled prevalence of pre-existing chronic kidney disease (CKD) and end-stage kidney disease was 5.2% (2.8–8.1) and 2.3% (1.8–2.8), respectively. The pooled incidence over follow-up of 2–28 days was 12.5% (10.1–15.0) for electrolyte disturbance (e.g. hyperkalaemia), 11.0% (7.4–15.1) for acute kidney injury (AKI) and 6.8% (1.0–17.0) for renal replacement therapy (RRT). In subgroup analyses, there was a higher incidence of AKI in US populations and groups with higher prevalence of pre-existing CKD. Conclusions Frequent renal complications reported among hospitalized COVID-19 patients are electrolyte disturbance, AKI and RRT. Aggressive monitoring and management of these renal complications may help in the prediction of favourable outcomes.

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    Keywords renal complications ; acute kidney injury ; COVID-19 ; meta-analysis ; covid19
    Language englanti
    Publishing date 2020-11-12T11:37:34Z
    Publisher Informa UK Limited
    Publishing country fi
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Renal complications in COVID-19: a systematic review and meta-analysis.

    Kunutsor, Setor K / Laukkanen, Jari A

    Annals of medicine

    2020  Volume 52, Issue 7, Page(s) 345–353

    Abstract: ... reporting renal complications in COVID-19 patients were sought from MEDLINE, Embase and the Cochrane Library ... of COVID-19 and their incidence using a systematic meta-analysis.: Design: Observational studies ... Conclusions: Frequent renal complications reported among hospitalized COVID-19 patients are electrolyte ...

    Abstract Purpose: Emerging data suggest that coronavirus disease 2019 (COVID-19) has extrapulmonary manifestations but its renal manifestations are not clearly defined. We aimed to evaluate renal complications of COVID-19 and their incidence using a systematic meta-analysis.
    Design: Observational studies reporting renal complications in COVID-19 patients were sought from MEDLINE, Embase and the Cochrane Library from 2019 to June 2020. The nine-star Newcastle-Ottawa Scale was used to evaluate methodological quality. Incidence with 95% confidence intervals (CIs) were pooled using random-effects models.
    Results: We included 22 observational cohort studies comprising of 17,391 COVID-19 patients. Quality scores of studies ranged from 4 to 6. The pooled prevalence of pre-existing chronic kidney disease (CKD) and end-stage kidney disease was 5.2% (2.8-8.1) and 2.3% (1.8-2.8), respectively. The pooled incidence over follow-up of 2-28 days was 12.5% (10.1-15.0) for electrolyte disturbance (e.g. hyperkalaemia), 11.0% (7.4-15.1) for acute kidney injury (AKI) and 6.8% (1.0-17.0) for renal replacement therapy (RRT). In subgroup analyses, there was a higher incidence of AKI in US populations and groups with higher prevalence of pre-existing CKD.
    Conclusions: Frequent renal complications reported among hospitalized COVID-19 patients are electrolyte disturbance, AKI and RRT. Aggressive monitoring and management of these renal complications may help in the prediction of favourable outcomes.
    MeSH term(s) Acute Kidney Injury/epidemiology ; Acute Kidney Injury/virology ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Humans ; Incidence ; Kidney Failure, Chronic/complications ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Prevalence ; Renal Insufficiency, Chronic/complications ; Water-Electrolyte Imbalance/epidemiology ; Water-Electrolyte Imbalance/virology
    Keywords covid19
    Language English
    Publishing date 2020-07-10
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2020.1790643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: COVID-19 and maintenance hemodialysis: a systematic scoping review of practice guidelines.

    Akbarialiabad, Hossein / Kavousi, Shahin / Ghahramani, Aria / Bastani, Bahar / Ghahramani, Nasrollah

    BMC nephrology

    2020  Volume 21, Issue 1, Page(s) 470

    Abstract: ... management of patients with End Stage Renal Disease (ESRD) and COVID-19. ... to patients with end stage renal disease faced challenges in safeguarding patients and staff while providing ... research.: Methods: Using the terms: "Dialysis" OR "RRT" OR "Renal replacement therapy" AND "SARS-COV-2" OR "COVID ...

    Abstract Background: Coronavirus Disease 2019 (COVID-19) has substantially impacted the provision of medical services. During the pandemic, many medical services, including facilities providing care to patients with end stage renal disease faced challenges in safeguarding patients and staff while providing clinical care. This study aims to identify the extent, range, and nature of articles related to COVID-19 and maintenance hemodialysis to understand the research gaps and propose recommendations for future research.
    Methods: Using the terms: "Dialysis" OR "RRT" OR "Renal replacement therapy" AND "SARS-COV-2" OR "COVID-19" OR "novel coronavirus" OR "2019-nCov", we performed a multi-step systematic search of the literature in the English language in Pubmed, Scopus, Embase, and Web of Science published from December 1, 2019, to May 13, 2020. Two authors separately screened the title and abstracts of the documents and ruled out irrelevant articles. We obtained a full report of the papers that met our inclusion criteria and screened the full texts. We conducted a descriptive analysis of the characteristics of the included articles and performed a narrative synthesis of the results. We conducted this scoping review in accordance with the PRISMA-ScR Checklist.
    Results: We included 22 articles in this scoping review. Perspectives (n = 9), editorials (n = 4), and case series (n = 5) were the most common types of articles. Most articles were from Italy and the United States. Seventeen (77.3%) of the articles focused on the topic of recommendation for outpatient hemodialysis units. While many of the recommendations overlapped in several articles, there were also many unique recommendations.
    Conclusions: most of the articles are based on single-center experience, which spontaneously developed best practices. Many of these practices have formed the basis for policies and guidelines that will guide future prevention of infection and management of patients with End Stage Renal Disease (ESRD) and COVID-19.
    MeSH term(s) Adult ; Betacoronavirus ; Body Temperature ; COVID-19 ; COVID-19 Testing ; Child ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Friends ; Health Personnel/education ; Hemodialysis, Home ; Humans ; Kidney Failure, Chronic/therapy ; Pandemics/prevention & control ; Patient Education as Topic ; Personal Protective Equipment ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Practice Guidelines as Topic ; Quarantine/methods ; Renal Dialysis/standards ; Renal Replacement Therapy ; SARS-CoV-2 ; Symptom Assessment
    Keywords covid19
    Language English
    Publishing date 2020-11-10
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-020-02143-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Covid-19 in end-stage renal disease patients with renal replacement therapies

    Tanawin Nopsopon / Jathurong Kittrakulrat / Kullaya Takkavatakarn / Thanee Eiamsitrakoon / Talerngsak Kanjanabuch / Krit Pongpirul

    PLoS Neglected Tropical Diseases, Vol 15, Iss 6, p e

    A systematic review and meta-analysis.

    2021  Volume 0009156

    Abstract: ... End-stage renal disease (ESRD) patients with renal replacement therapy (RRT) might have a higher prevalence and CFR due ... This meta-analysis suggested high COVID-19 prevalence and CFR in ESRD patients with RRT. ESRD patients with RRT ... meta-analysis up to June 30, 2020, to evaluate the prevalence and case fatality rate (CFR) of the COVID-19 ...

    Abstract Background The novel coronavirus (COVID-19), caused by SARS-CoV-2, showed various prevalence and case-fatality rates (CFR) among patients with different pre-existing chronic conditions. End-stage renal disease (ESRD) patients with renal replacement therapy (RRT) might have a higher prevalence and CFR due to reduced immune function from uremia and kidney tropism of SARS-CoV-2, but there was a lack of systematic study on the infection and mortality of the SARS-CoV-2 infection in ESRD patients with various RRT. Methodology/principal findings We searched five electronic databases and performed a systematic review and meta-analysis up to June 30, 2020, to evaluate the prevalence and case fatality rate (CFR) of the COVID-19 infection among ESRD patients with RRT. The global COVID-19 data were retrieved from the international database on June 30, 2020, for estimating the prevalence and CFR of the general population as referencing points. Of 3,272 potential studies, 34 were eligible studies consisted of 1,944 COVID-19 confirmed cases in 21,873 ESRD patients with RRT from 12 countries in four WHO regions. The overall pooled prevalence in ESRD patients with RRT was 3.10% [95% confidence interval (CI) 1.25-5.72] which was higher than referencing 0.14% global average prevalence. The overall estimated CFR of COVID-19 in ESRD patients with RRT was 18.06% (95% CI 14.09-22.32) which was higher than the global average at 4.98%. Conclusions This meta-analysis suggested high COVID-19 prevalence and CFR in ESRD patients with RRT. ESRD patients with RRT should have their specific protocol of COVID-19 prevention and treatment to mitigate excess cases and deaths.
    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Subject code 616 ; 610
    Language English
    Publishing date 2021-06-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Renal complications in COVID-19:A systematic review and meta-analysis

    Kunutsor, Setor K / Laukkanen, Jari A

    Kunutsor , S K & Laukkanen , J A 2020 , ' Renal complications in COVID-19 : A systematic review and meta-analysis ' , Annals of Medicine , vol. 52 , no. 7 . https://doi.org/10.1080/07853890.2020.1790643

    2020  

    Abstract: ... renal complications in COVID-19 patients were sought from MEDLINE, Embase and the Cochrane Library ... of COVID-19 and their incidence using a systematic meta-analysis. Design: Observational studies reporting ... Conclusions: Frequent renal complications reported among hospitalised COVID-19 patients are electrolyte ...

    Abstract Purpose: Emerging data suggests coronavirus disease 2019 (COVID-19) has extrapulmonary manifestations but its renal manifestations are not clearly defined. We aimed to evaluate renal complications of COVID-19 and their incidence using a systematic meta-analysis. Design: Observational studies reporting renal complications in COVID-19 patients were sought from MEDLINE, Embase and the Cochrane Library from 2019 to June 2020. The nine-star Newcastle-Ottawa Scale was used to evaluate methodological quality. Incidence with 95% confidence intervals (CIs) were pooled using random-effects models. Results: We included 22 observational cohort studies comprising of 17,391 COVID-19 patients. Quality scores of studies ranged from 4-6. The pooled prevalence of pre-existing chronic kidney disease (CKD) and end-stage kidney disease was 5.2% (2.8-8.1) and 2.3% (1.8-2.8) respectively. The pooled incidence over follow-up of 2-28 days was 12.5% (10.1-15.0) for electrolyte disturbance (eg, hyperkalaemia), 11.0% (7.4-15.1) for acute kidney injury (AKI) and 6.8% (1.0-17.0) for renal replacement therapy (RRT). In subgroup analyses, there was a higher incidence of AKI in US populations and groups with higher prevalence of pre-existing CKD. Conclusions: Frequent renal complications reported among hospitalised COVID-19 patients are electrolyte disturbance, AKI and RRT. Aggressive monitoring and management of these renal complications may help in the prediction of favourable outcomes.
    Keywords /dk/atira/pure/core/keywords/uob_covid19 ; Covid19 ; COVID-19 ; Renal complications ; acute kidney injury ; meta-analysis ; /dk/atira/pure/researchoutput/pubmedpublicationtype/D016428 ; Journal Article ; /dk/atira/pure/researchoutput/pubmedpublicationtype/D013485 ; Research Support ; Non-U.S. Gov't ; /dk/atira/pure/researchoutput/pubmedpublicationtype/D017418 ; /dk/atira/pure/researchoutput/pubmedpublicationtype/D000078182 ; Systematic Review ; covid19
    Language English
    Publishing date 2020-07-10 ; info:eu-repo/date/embargoEnd/2021-07-10
    Publishing country uk
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Renal complications in COVID-19: a systematic review and meta-analysis

    Kunutsor, Setor K / Laukkanen, Jari A

    Ann Med

    Abstract: ... renal complications in COVID-19 patients were sought from MEDLINE, Embase and the Cochrane Library ... of COVID-19 and their incidence using a systematic meta-analysis. DESIGN: Observational studies reporting ... CONCLUSIONS: Frequent renal complications reported among hospitalized COVID-19 patients are electrolyte ...

    Abstract PURPOSE: Emerging data suggest that coronavirus disease 2019 (COVID-19) has extrapulmonary manifestations but its renal manifestations are not clearly defined. We aimed to evaluate renal complications of COVID-19 and their incidence using a systematic meta-analysis. DESIGN: Observational studies reporting renal complications in COVID-19 patients were sought from MEDLINE, Embase and the Cochrane Library from 2019 to June 2020. The nine-star Newcastle-Ottawa Scale was used to evaluate methodological quality. Incidence with 95% confidence intervals (CIs) were pooled using random-effects models. RESULTS: We included 22 observational cohort studies comprising of 17,391 COVID-19 patients. Quality scores of studies ranged from 4 to 6. The pooled prevalence of pre-existing chronic kidney disease (CKD) and end-stage kidney disease was 5.2% (2.8-8.1) and 2.3% (1.8-2.8), respectively. The pooled incidence over follow-up of 2-28 days was 12.5% (10.1-15.0) for electrolyte disturbance (e.g. hyperkalaemia), 11.0% (7.4-15.1) for acute kidney injury (AKI) and 6.8% (1.0-17.0) for renal replacement therapy (RRT). In subgroup analyses, there was a higher incidence of AKI in US populations and groups with higher prevalence of pre-existing CKD. CONCLUSIONS: Frequent renal complications reported among hospitalized COVID-19 patients are electrolyte disturbance, AKI and RRT. Aggressive monitoring and management of these renal complications may help in the prediction of favourable outcomes. Systematic review registration: PROSPERO 2020: CRD42020186873 KEY MESSAGES COVID-19 affects multiple organs apart from the respiratory system; however, its renal manifestations are not clearly defined. In this systematic meta-analysis of 22 observational cohort studies, the prevalence of pre-existing chronic kidney disease (CKD) in COVID-19 patients was 5.2%. The most frequent renal complication was electrolyte disturbance (particularly hyperkalaemia) with an incidence of 12.5% followed by acute kidney injury (AKI) with an incidence of 11.0%; US populations and groups with higher prevalence of CKD had higher incidence of AKI.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #640131
    Database COVID19

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  9. Article: COVID-19 and maintenance hemodialysis: a systematic scoping review of practice guidelines

    Akbarialiabad, Hossein / Kavousi, Shahin / Ghahramani, Aria / Bastani, Bahar / Ghahramani, Nasrollah

    BMC Nephrol

    Abstract: ... and management of patients with End Stage Renal Disease (ESRD) and COVID-19. ... with end stage renal disease faced challenges in safeguarding patients and staff while providing clinical care. This study aims ... Dialysis" OR "RRT" OR "Renal replacement therapy" AND "SARS-COV-2" OR "COVID-19" OR "novel coronavirus" OR ...

    Abstract BACKGROUND: Coronavirus Disease 2019 (COVID-19) has substantially impacted the provision of medical services. During the pandemic, many medical services, including facilities providing care to patients with end stage renal disease faced challenges in safeguarding patients and staff while providing clinical care. This study aims to identify the extent, range, and nature of articles related to COVID-19 and maintenance hemodialysis to understand the research gaps and propose recommendations for future research. METHODS: Using the terms: "Dialysis" OR "RRT" OR "Renal replacement therapy" AND "SARS-COV-2" OR "COVID-19" OR "novel coronavirus" OR "2019-nCov", we performed a multi-step systematic search of the literature in the English language in Pubmed, Scopus, Embase, and Web of Science published from December 1, 2019, to May 13, 2020. Two authors separately screened the title and abstracts of the documents and ruled out irrelevant articles. We obtained a full report of the papers that met our inclusion criteria and screened the full texts. We conducted a descriptive analysis of the characteristics of the included articles and performed a narrative synthesis of the results. We conducted this scoping review in accordance with the PRISMA-ScR Checklist. RESULTS: We included 22 articles in this scoping review. Perspectives (n = 9), editorials (n = 4), and case series (n = 5) were the most common types of articles. Most articles were from Italy and the United States. Seventeen (77.3%) of the articles focused on the topic of recommendation for outpatient hemodialysis units. While many of the recommendations overlapped in several articles, there were also many unique recommendations. CONCLUSIONS: most of the articles are based on single-center experience, which spontaneously developed best practices. Many of these practices have formed the basis for policies and guidelines that will guide future prevention of infection and management of patients with End Stage Renal Disease (ESRD) and COVID-19.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #917922
    Database COVID19

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