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  1. Article ; Online: Neurodegenerative disorders and nanoformulated drug development.

    Nowacek, Ari / Kosloski, Lisa M / Gendelman, Howard E

    Nanomedicine (London, England)

    2009  Volume 4, Issue 5, Page(s) 541–555

    Abstract: ... neurocognitive disorders. These are common, debilitating and, unfortunately, hold few therapeutic options. In recent years ... pharmacokinetics and drug delivery specifically to CNS-diseased areas. In addition, nanomedical advances are ... leading to therapies that target CNS pathobiology and as such, can interrupt disordered protein ...

    Abstract Degenerative and inflammatory diseases of the CNS include, but are not limited to, Alzheimer's and Parkinson's disease, amyotrophic lateral sclerosis, stroke, multiple sclerosis and HIV-1-associated neurocognitive disorders. These are common, debilitating and, unfortunately, hold few therapeutic options. In recent years, the application of nanotechnologies as commonly used or developing medicines has served to improve pharmacokinetics and drug delivery specifically to CNS-diseased areas. In addition, nanomedical advances are leading to therapies that target CNS pathobiology and as such, can interrupt disordered protein aggregation, deliver functional neuroprotective proteins and alter the oxidant state of affected neural tissues. This article focuses on the pathobiology of common neurodegenerative disorders with a view towards how nanomedicine may be used to improve the clinical course of neurodegenerative disorders.
    MeSH term(s) Animals ; Drug Design ; Humans ; Nanoparticles ; Neurodegenerative Diseases/drug therapy
    Language English
    Publishing date 2009-07-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2277839-1
    ISSN 1748-6963 ; 1743-5889
    ISSN (online) 1748-6963
    ISSN 1743-5889
    DOI 10.2217/nnm.09.37
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6617: Show issues Location:
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  2. Article ; Online: Harnessing Lysosomal pH through PLGA Nanoemulsion as a Treatment of Lysosomal-Related Neurodegenerative Diseases.

    Prévot, Geoffrey / Soria, Federico N / Thiolat, Marie-Laure / Daniel, Jonathan / Verlhac, Jean Baptiste / Blanchard-Desce, Mireille / Bezard, Erwan / Barthélémy, Philippe / Crauste-Manciet, Sylvie / Dehay, Benjamin

    Bioconjugate chemistry

    2018  Volume 29, Issue 12, Page(s) 4083–4089

    Abstract: Most neurodegenerative disorders are characterized by deposits of misfolded proteins and neuronal ... development aiming at restoring lysosomal function represents a novel, precise, and promising strategy ... Overall, these results suggest the feasibility and the therapeutic potential of this new nanoformulation ...

    Abstract Most neurodegenerative disorders are characterized by deposits of misfolded proteins and neuronal degeneration in specific brain regions. Growing evidence indicates that lysosomal impairment plays a primary pathogenic role in these diseases, in particular, the occurrence of increased lysosomal pH. Thus, therapeutic development aiming at restoring lysosomal function represents a novel, precise, and promising strategy for the treatment of these pathologies. Herein we demonstrate that acidic oil-in-water nanoemulsions loaded with poly(dl-lactide- co-glycolide) (PLGA) are able to rescue impaired lysosomal pH in genetic cellular models of Parkinson's disease. For in vivo assays, nanoemulsions were labeled with an original synthetic hydrophobic far red-emitting dye to allow fluorescence monitoring. Following stereotaxic injection in the mouse brain, widespread diffusion of the nanocarrier was observed, up to 500 μm from the injection site, as well as internalization into the lysosomal compartment in brain cells. Finally, promising preliminary assays of systemic administration demonstrate that a fraction of the formulation crosses the blood brain barrier, penetrates the brain parenchyma, is internalized by cells, and colocalizes with lysosomal markers. Overall, these results suggest the feasibility and the therapeutic potential of this new nanoformulation as an effective drug delivery tool to the brain, with the potential to rescue pathological lysosomal deficits.
    MeSH term(s) Animals ; Blood-Brain Barrier ; Cell Line, Tumor ; Drug Carriers ; Emulsions ; Endocytosis ; Humans ; Hydrogen-Ion Concentration ; Lysosomes/metabolism ; Mice ; Nanoparticles ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/metabolism ; Polylactic Acid-Polyglycolic Acid Copolymer/administration & dosage ; Polylactic Acid-Polyglycolic Acid Copolymer/pharmacokinetics ; Polylactic Acid-Polyglycolic Acid Copolymer/therapeutic use
    Chemical Substances Drug Carriers ; Emulsions ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS)
    Language English
    Publishing date 2018-11-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1024041-x
    ISSN 1520-4812 ; 1043-1802
    ISSN (online) 1520-4812
    ISSN 1043-1802
    DOI 10.1021/acs.bioconjchem.8b00697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (2.OG)
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