Article ; Online: TRPM7 is involved in acid-induced necrotic cell death in a manner sensitive to progesterone in human cervical cancer cells.
2019 Volume 7, Issue 13, Page(s) e14157
Abstract: ... on cervical cancer cells. Recently, in response to strong acidosis, human cervical cancer HeLa cells were shown ... to exhibit necrosis after showing persistent cell swelling induced by Cl ... Because intravaginal pH is strongly acidic, it is important to investigate the effects of acidosis ...
| Abstract | Because intravaginal pH is strongly acidic, it is important to investigate the effects of acidosis on cervical cancer cells. Recently, in response to strong acidosis, human cervical cancer HeLa cells were shown to exhibit necrosis after showing persistent cell swelling induced by Cl |
|---|---|
| MeSH term(s) | Apoptosis ; Cell Proliferation/drug effects ; Chlorides/metabolism ; Chlorides/pharmacology ; Female ; HEK293 Cells ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Necrosis ; Progesterone/pharmacology ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism ; Uterine Cervical Neoplasms/metabolism |
| Chemical Substances | Chlorides ; TRPM Cation Channels ; Progesterone (4G7DS2Q64Y) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; TRPM7 protein, human (EC 2.7.11.1) |
| Language | English |
| Publishing date | 2019-07-10 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2724325-4 |
| ISSN | 2051-817X ; 2051-817X |
| ISSN (online) | 2051-817X |
| ISSN | 2051-817X |
| DOI | 10.14814/phy2.14157 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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