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  1. Article ; Online: Covid-19: Third of people infected have long term symptoms.

    O'Dowd, Adrian

    BMJ (Clinical research ed.)

    2021  Volume 373, Page(s) n1626

    Language English
    Publishing date 2021-06-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.n1626
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Long-term complications after infection with SARS-CoV-1, influenza and MERS-CoV - Lessons to learn in long COVID?

    Løkke, F B / Hansen, K S / Dalgaard, L S / Öbrink-Hansen, K / Schiøttz-Christensen, B / Leth, S

    Infectious diseases now

    2023  Volume 53, Issue 8, Page(s) 104779

    Abstract: ... widely reported symptoms, respectively. Consistent with long-term sequelae from COVID-19, persisting ... Comparing long-term sequelae following COVID-19 to those of other respiratory viruses such as influenza ... the long-term sequelae following COVID-19 are a significant concern, and while long-term sequelae following ...

    Abstract The COVID-19 pandemic has affected millions of people worldwide, and while the mortality rate remains the primary concern, it is becoming increasingly apparent that many COVID-19 survivors experience long-term sequelae, representing a major concern for both themselves and healthcare providers. Comparing long-term sequelae following COVID-19 to those of other respiratory viruses such as influenza, MERS-CoV, and SARS-CoV-1 is an essential step toward understanding the extent and impact of these sequelae. A literature search was carried out using the PubMed. database. Search-terms included "persistent", "long-term", "chronic", and MeSH-terms for SARS-CoV-1, MERS-CoV and Influenza. Only English-language articles were selected. Articles were screened by title/abstract and full-text readings. Key points for comparison were persistent symptoms > 4 weeks, virus type, study design, population size, admission status, methods, and findings. Thirty-one articles were included: 19 on SARS-CoV-1, 10 on influenza, and 2 on MERS-CoV-survivors. Damage to the respiratory system was the main long-term manifestation after the acute phase of infection. Quality of life-related and psychological sequelae were the second and third most widely reported symptoms, respectively. Consistent with long-term sequelae from COVID-19, persisting cardiovascular, neurological, musculoskeletal, gastrointestinal impairments were also reported. In summary, the long-term sequelae following COVID-19 are a significant concern, and while long-term sequelae following influenza, MERS-CoV, and SARS-CoV-1 have also been reported, their prevalence and severity are less clear. It is essential to continue to study and monitor the long-term effects of all respiratory viruses so as to improve our understanding and develop strategies for prevention and treatment.
    MeSH term(s) Humans ; Severe acute respiratory syndrome-related coronavirus ; COVID-19/complications ; Middle East Respiratory Syndrome Coronavirus ; Post-Acute COVID-19 Syndrome ; Influenza, Human/complications ; Influenza, Human/epidemiology ; SARS-CoV-2 ; Pandemics ; Quality of Life
    Language English
    Publishing date 2023-09-09
    Publishing country France
    Document type Journal Article ; Review
    ISSN 2666-9919
    ISSN (online) 2666-9919
    DOI 10.1016/j.idnow.2023.104779
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: COPING WITH COVID-19

    Farooq Naeem / Muhammad Irfan / Afzal Javed

    Khyber Medical University Journal, Vol 12, Iss

    URGENT NEED FOR BUILDING RESILIENCE THROUGH COGNITIVE BEHAVIOUR THERAPY

    2020  Volume 1

    Abstract: ... to emotional health problems.4 It is difficult to predict the long-term physical and mental health consequences ... with health promotional behaviour and quality of life.19 While several Multimedia based or face-to-face programmes have ... At the start of 2020, originating from Wuhan city, coronavirus disease 2019 (COVID-19) started ...

    Abstract At the start of 2020, originating from Wuhan city, coronavirus disease 2019 (COVID-19) started to spread throughout China.1 The World Health Organization has declared this to be a pandemic.2 Both healthcare workers and the general public have been experiencing psychological problems, including anxiety, depression, and stress, as a result of the rapidly increasing numbers of confirmed cases and deaths.3 Isolation strategies are used throughout the world to limit the spread of the virus. While these strategies are essential in protecting lives, isolation might add to the stress and is highly likely to lead to emotional health problems.4 It is difficult to predict the long-term physical and mental health consequences of COVID-19. However, an economic crisis is highly likely to follow that might worsen the mental and emotional health problems across the nations.5. There is a need to develop and test evidence-based interventions that can help build resilient communities to help people cope with the current situation, deal with physical health issues as well as the personal trauma, and most importantly to prevent future emotional and mental health problems. Such intervention should also be low cost, easy to deliver in a variety of formats at a public health scale. We believe Cognitive Behaviour Therapy (CBT) is the ideal interventional tool to build resilience. The philosophical origins of cognitive therapy can be traced back to stoic philosophers. Epictetus famously wrote in “The Enchiridion,”“Men are disturbed not by things but by the view which they take of them.” CBT originated with the formulation of a cognitive model of depressive illness, which evolved from systematic clinical observations and experimental testing.6 CBT is an active, directive, structured, and time-limited approach to treat a variety of problems. It is based on the principle that a person’s emotions and behaviours are primarily determined by the way in which he perceives the world. The cognitions (thoughts) are based on assumptions or attitudes, developed from previous experiences. Therapeutic techniques are used to identify, reality test, and correct distorted thinking patterns and the dysfunctional beliefs underlying these thinking patterns. The therapist helps the patient to think and act more realistically and adaptively about his psychological problems and thus reduce symptoms. The cognitive model postulates three specific concepts to explain the psychological basis of depressive illness; (a) the cognitive triad i.e., what a person thinks about the self, others and the future, (b) dysfunctional beliefs i.e., beliefs that are formed during early development and are triggered when a person faces a challenging situation and the (c) cognitive errors. The common cognitive errors include; black and white thinking, jumping to conclusions, overgeneralization, minimization and magnification, personalization, selective abstraction and catastrophization.6 We all make “cognitive errors”; however, most of us can deal with these. A person with high levels of vulnerability to emotional or mental health problems or facing high levels of stress might fail to address their cognitive errors. It has been suggested that when faced with a challenging situation, a person might catastrophize such as, “This is horrible, I am not going to survive Corona, or “What is the point. We all are going to die”. They might then feel low, experience hopelessness, and stop attempting to keep themselves safe during the pandemic. In CBT, the therapist helps a person in identify their automatic, negative thoughts and unhelpful behaviours, and eventually modify the thoughts and behaviours. They specifically teach them empowering skills to help them manage the situation, help develop healthy coping skills and deal with their concerns such as isolation. However, CBT is not promoting positive emotions. So, rather than saying “don’t worry, everything is going to be fine” the therapist will help the person to examine the current evidence, so that they develop a rational understanding of the situation, such as “yes, it is an uncertain situation, but prevention has saved many lives and the rates of recovery among those infected is very high”. Additionally, the therapist might use normalization, behavioral activation with a particular focus on physical activities, lifestyle changes and stress, and sleep management to help the person. CBT is recommended by the national guidelines to treat mental and emotional health problems in most developed nations.7,8 The effects of CBT have been studied for various disorders and health problems.9,10 There is also evidence to suggest that CBT delivered through the internet can directly help health problems.11 Third wave CBT approaches such as mindfulness and Acceptance and Commitment Therapy (ACT) have also been used to help those with chronic physical conditions.12 CBT has also been adapted for use across cultures and sub-cultures.13,14 Most importantly, evidence from research suggests that CBT can be used to increase resilience.15 Resilience, which is described as the ability to recover readily from adversity and individuals using positive emotions in adverse circumstances have been found to be resilient.16 It is evident from the literature that highly resilient individuals nurture their positive emotionsproactively.16 This certainly has implications for managing stress, boredom, and change. As resilience has been associated with better coping with mental and physical health problems and healthy aging.17 There is evidence to suggest that resilience can act as a protective factor against the development of psychopathology among those facing challenges.18 Resilience impacts both the illness process and outcome in health. According to a systematic review, resilience plays an important role in the treatment of chronic diseases, such as diabetes, rheumatoid arthritis, juvenile idiopathic arthritis, systemic lupus erythematosus, and Chagas disease.19 A negative relationship between resilience and common mental disorders (depression, anxiety, and somatization) has also been suggested in the same systematic review. Another important finding of the review was the inverse correlation between resilience scores and the progression of various illnesses and an association of resilience with health promotional behaviour and quality of life.19 While several Multimedia based or face-to-face programmes have assessed the usefulness of CBT for resilience in a variety of populations,20 it has not been used to build resilience in persons facing challenging situations to help ease their distress and to prevent the development of psychopathology. CBT is an ideal intervention for victims of humanitarian crises such as earthquakes, floods, wars related trauma, and pandemics as it is evidence-based, structured, low cost, and can be delivered in a variety of formats, including online platforms. There is an urgent need to develop and test CBT based programs that focus on building resilience that can be used on a public health level to help persons facing challenges at national or global levels. We, therefore, believe that developing and testing CBT based interventions to build resilience among those facing challenging situations is a need of time.
    Keywords COVID-19 ; COVID-19 pandemic ; 2019 novel coronavirus infection ; coronavirus disease-19 ; Cognitive Behavioral Therapy ; CBT ; Medicine ; R ; covid19
    Subject code 360
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Khyber Medical University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: COPING WITH COVID-19

    Naeem, Farooq / Irfan, Muhammad / Javed, Afzal

    KHYBER MEDICAL UNIVERSITY JOURNAL; Vol 12 No; VOL 12; ISSUE 1 - JAN - MAR; 1-3 ; 2305-2651 ; 2305-2643

    URGENT NEED FOR BUILDING RESILIENCE THROUGH COGNITIVE BEHAVIOUR THERAPY

    2020  Volume 1, Issue : KMUJ 2020

    Abstract: ... to emotional health problems.4 It is difficult to predict the long-term physical and mental health consequences ... 19 While several Multimedia based or face-to-face programmes have assessed the usefulness of CBT ... At the start of 2020, originating from Wuhan city, coronavirus disease 2019 (COVID-19) started ...

    Abstract At the start of 2020, originating from Wuhan city, coronavirus disease 2019 (COVID-19) started to spread throughout China.1 The World Health Organization has declared this to be a pandemic.2 Both healthcare workers and the general public have been experiencing psychological problems, including anxiety, depression, and stress, as a result of the rapidly increasing numbers of confirmed cases and deaths.3 Isolation strategies are used throughout the world to limit the spread of the virus. While these strategies are essential in protecting lives, isolation might add to the stress and is highly likely to lead to emotional health problems.4 It is difficult to predict the long-term physical and mental health consequences of COVID-19. However, an economic crisis is highly likely to follow that might worsen the mental and emotional health problems across the nations.5. There is a need to develop and test evidence-based interventions that can help build resilient communities to help people cope with the current situation, deal with physical health issues as well as the personal trauma, and most importantly to prevent future emotional and mental health problems. Such intervention should also be low cost, easy to deliver in a variety of formats at a public health scale. We believe Cognitive Behaviour Therapy (CBT) is the ideal interventional tool to build resilience. The philosophical origins of cognitive therapy can be traced back to stoic philosophers. Epictetus famously wrote in “The Enchiridion,”“Men are disturbed not by things but by the view which they take of them.” CBT originated with the formulation of a cognitive model of depressive illness, which evolved from systematic clinical observations and experimental testing.6 CBT is an active, directive, structured, and time-limited approach to treat a variety of problems. It is based on the principle that a person’s emotions and behaviours are primarily determined by the way in which he perceives the world. The cognitions (thoughts) are based on assumptions or attitudes, developed from previous experiences. Therapeutic techniques are used to identify, reality test, and correct distorted thinking patterns and the dysfunctional beliefs underlying these thinking patterns. The therapist helps the patient to think and act more realistically and adaptively about his psychological problems and thus reduce symptoms. The cognitive model postulates three specific concepts to explain the psychological basis of depressive illness; (a) the cognitive triad i.e., what a person thinks about the self, others and the future, (b) dysfunctional beliefs i.e., beliefs that are formed during early development and are triggered when a person faces a challenging situation and the (c) cognitive errors. The common cognitive errors include; black and white thinking, jumping to conclusions, overgeneralization, minimization and magnification, personalization, selective abstraction and catastrophization.6 We all make “cognitive errors”; however, most of us can deal with these. A person with high levels of vulnerability to emotional or mental health problems or facing high levels of stress might fail to address their cognitive errors. It has been suggested that when faced with a challenging situation, a person might catastrophize such as, “This is horrible, I am not going to survive Corona, or “What is the point. We all are going to die”. They might then feel low, experience hopelessness, and stop attempting to keep themselves safe during the pandemic. In CBT, the therapist helps a person in identify their automatic, negative thoughts and unhelpful behaviours, and eventually modify the thoughts and behaviours. They specifically teach them empowering skills to help them manage the situation, help develop healthy coping skills and deal with their concerns such as isolation. However, CBT is not promoting positive emotions. So, rather than saying “don’t worry, everything is going to be fine” the therapist will help the person to examine the current evidence, so that they develop a rational understanding of the situation, such as “yes, it is an uncertain situation, but prevention has saved many lives and the rates of recovery among those infected is very high”. Additionally, the therapist might use normalization, behavioral activation with a particular focus on physical activities, lifestyle changes and stress, and sleep management to help the person. CBT is recommended by the national guidelines to treat mental and emotional health problems in most developed nations.7,8 The effects of CBT have been studied for various disorders and health problems.9,10 There is also evidence to suggest that CBT delivered through the internet can directly help health problems.11 Third wave CBT approaches such as mindfulness and Acceptance and Commitment Therapy (ACT) have also been used to help those with chronic physical conditions.12 CBT has also been adapted for use across cultures and sub-cultures.13,14 Most importantly, evidence from research suggests that CBT can be used to increase resilience.15 Resilience, which is described as the ability to recover readily from adversity and individuals using positive emotions in adverse circumstances have been found to be resilient.16 It is evident from the literature that highly resilient individuals nurture their positive emotionsproactively.16 This certainly has implications for managing stress, boredom, and change. As resilience has been associated with better coping with mental and physical health problems and healthy aging.17 There is evidence to suggest that resilience can act as a protective factor against the development of psychopathology among those facing challenges.18 Resilience impacts both the illness process and outcome in health.According to a systematic review, resilience plays an important role in the treatment of chronic diseases, such as diabetes, rheumatoid arthritis, juvenile idiopathic arthritis, systemic lupus erythematosus, and Chagas disease.19 A negative relationship between resilience and common mental disorders (depression, anxiety, and somatization) has also been suggested in the same systematic review. Another important finding of the review was the inverse correlation between resilience scores and the progression of various illnesses and an association of resilience with health promotional behaviour and quality of life.19 While several Multimedia based or face-to-face programmes have assessed the usefulness of CBT for resilience in a variety of populations,20 it has not been used to build resilience in persons facing challenging situations to help ease their distress and to prevent the development of psychopathology. CBT is an ideal intervention for victims of humanitarian crises such as earthquakes, floods, wars related trauma, and pandemics as it is evidence-based, structured, low cost, and can be delivered in a variety of formats, including online platforms. There is an urgent need to develop and test CBT based programs that focus on building resilience that can be used on a public health level to help persons facing challenges at national or global levels. We, therefore, believe that developing and testing CBT based interventions to build resilience among those facing challenging situations is a need of time.
    Keywords COVID-19 ; COVID-19 pandemic ; 2019 novel coronavirus infection ; coronavirus disease-19 ; Cognitive Behavioral Therapy ; CBT ; Pakistan ; Pandemic ; covid19
    Subject code 360
    Language English
    Publishing date 2020-03-31
    Publisher Khyber Medical University (KMU) Peshawar PAKISTAN
    Publishing country us
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Exploring long COVID condition in Latin America: Its impact on patients' activities and associated healthcare use.

    Angarita-Fonseca, Adriana / Torres-Castro, Rodrigo / Benavides-Cordoba, Vicente / Chero, Santos / Morales-Satán, Mauricio / Hernández-López, Bricia / Salazar-Pérez, Rafael / Larrateguy, Santiago / Sanchez-Ramirez, Diana C

    Frontiers in medicine

    2023  Volume 10, Page(s) 1168628

    Abstract: ... symptoms (≥3 months). These were more likely to have COVID-19 earlier in the pandemic, were older, had no ... COVID-19 symptoms during the infectious period. 33% of the respondents visited a primary care provider ... invited to complete a virtual survey. Sociodemographic characteristics, COVID-19 and LCC symptoms ...

    Abstract Background: Studies exploring long COVID condition (LCC) in low- and middle-income countries are scarce. Further characterization of LCC patients experiencing activity limitations and their associated healthcare use is needed. This study aimed to describe LCC patients' characteristics, its impact on activities, and associated healthcare use in Latin America (LATAM).
    Participants: Individuals who (cared for someone or) had COVID-19 and could read, write, and comprehend Spanish and lived in a LATAM country were invited to complete a virtual survey. Sociodemographic characteristics, COVID-19 and LCC symptoms, activity limitations, and healthcare use.
    Results: Data from 2,466 people from 16 countries in LATAM were analyzed (females = 65.9%; mean age of 39.5 ± 53.3 years). 1,178 (48%) of the respondents had LCC symptoms (≥3 months). These were more likely to have COVID-19 earlier in the pandemic, were older, had no COVID vaccines, had more comorbidities, needed supplementary oxygen, and reported significantly more COVID-19 symptoms during the infectious period. 33% of the respondents visited a primary care provider, 13% went to the emergency department, 5% were hospitalized, 21% visited a specialist, and 32% consulted ≥1 therapist for LCC symptoms mainly extreme fatigue, sleep difficulties, headaches, muscle or joint pain, and shortness of breath with activity. The most consulted therapists were respiratory therapists (15%) and psychologists (14%), followed by physical therapists (13%), occupational therapists (3%), and speech pathologists (1%). One-third of LCC respondents decreased their regular activities (e.g., work, school) and 8% needed help with activities of daily living (ADLs). LCC respondents who reduced their activities reported more difficulty sleeping, chest pain with activity, depression, and problems with concentration, thinking, and memory, while those who needed help with ADLs were more likely to have difficulty walking, and shortness of breath at rest. Approximately 60% of respondents who experienced activity limitations sought a specialist and 50% consulted therapists.
    Conclusions and relevance: Results supported previous findings in terms of the LCC demographics, and provided insight into LCC impact on patients' activities and healthcare services used in LATAM. This information is valuable to inform service planning and resource allocation in alignment with the needs of this population.
    Language English
    Publishing date 2023-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1168628
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Covid-19: thuis uitzieken valt niet mee.

    Landsman, J A / Verheij, N P / Alma, M A / van den Boogaard, J / Luning-Koster, M / Evenboer, K E / van der Mei, S F / Reijneveld, S A

    Nederlands tijdschrift voor geneeskunde

    2020  Volume 164

    Abstract: ... of healthcare professionals (HCPs) who tested positive for COVID-19 and were not hospitalized because of mild symptoms, 2 ... fatigue as a long-term symptom, less frequently mentioned were, among other things, feeling physically ... The isolation at home was considered bearable.: Conclusion: A COVID-19 infection has a significant impact ...

    Title translation COVID-19: recovering at home is not easy.
    Abstract Objective: To gain insight into 1) the symptoms and the disease process of healthcare professionals (HCPs) who tested positive for COVID-19 and were not hospitalized because of mild symptoms, 2) the impact on their psychological well-being and 3) the experiences with (after) care and infection prevention measures.
    Design: Explorative mixed-methods study.
    Method: The municipal public health services of Groningen and Fryslân invited all HCPs aged above 18 years who tested positive for COVID-19 between March 18th and April 3rd 2020 to fill out an online questionnaire (n = 109), on average one month after diagnosis. 18 HCPs participated in telephone interviews.
    Results: Almost all HCPs mentioned fatigue as a long-term symptom, less frequently mentioned were, among other things, feeling physically weak and having a cold. Nearly half of them did not have a fever, two-thirds experienced stress. HCPs with comorbidity had more symptoms. The interviews showed that stress in particular occurred in families with children and because of uncertainty about the duration of infectiousness, with lack of good (after)care. Respondents experienced many negative reactions of people in their environment that felt stigmatizing. The isolation at home was considered bearable.
    Conclusion: A COVID-19 infection has a significant impact on physical and mental health, even in HCPs with mild symptoms. Persistent fatigue in particular hinders patients' functioning. The absence of fever in almost half of the respondents is remarkable, as well as the negative impact on psychological well-being. HCPs are also dissatisfied with after-care. Infection prevention measures were relatively well-adhered too.
    MeSH term(s) Adult ; Aftercare/methods ; Aftercare/psychology ; Aftercare/standards ; COVID-19/diagnosis ; COVID-19/physiopathology ; COVID-19/psychology ; COVID-19/rehabilitation ; Diagnostic Self Evaluation ; Fatigue/diagnosis ; Fatigue/etiology ; Female ; Health Personnel/psychology ; Health Personnel/statistics & numerical data ; Humans ; Interviews as Topic ; Male ; Mental Health ; Needs Assessment ; Netherlands/epidemiology ; SARS-CoV-2/isolation & purification ; Stress, Psychological/diagnosis ; Stress, Psychological/etiology
    Language Dutch
    Publishing date 2020-12-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Knowledge, attitudes, practices, and the effects of COVID-19 among the youth in Kenya.

    Karijo, Evalin / Wamugi, Sylvia / Lemanyishoe, Samuel / Njuki, Jenny / Boit, Faith / Kibui, Vania / Karanja, Sarah / Abuya, Timothy

    BMC public health

    2021  Volume 21, Issue 1, Page(s) 1020

    Abstract: ... such as employment status, gender, and education level.: Results: Knowledge on symptoms of COVID-19 was generally high ... reported feeling stressed.: Conclusion: There was high knowledge of COVID-19 symptoms, preventive ... Background: Cases of the Corona Virus Disease of 2019 (COVID-19) in Kenya have continued ...

    Abstract Background: Cases of the Corona Virus Disease of 2019 (COVID-19) in Kenya have continued to increase rapidly, since the first case in the country was confirmed in March 2020. In the wake of the pandemic, the health and socio-economic challenges experienced by the youth in Kenya are likely to be elevated. We assessed knowledge, practices, perceived risk of infection, adoption of recommended behaviour and the effects of COVID-19 among the youth in Kenya.
    Methods: A cross sectional descriptive study was conducted between April 30th to May 7th, 2020 through a combined online survey and phone interviews. A total of 2156 youth across all 47 counties in Kenya completed the responses to the study questions. All survey responses analyzed using Stata version 15 were tabulated by gender, age, and education level to generate basic descriptive tables and tested for differences by category using chi-square tests. Where applicable, linear and logistic regression analysis model was conducted using covariates such as employment status, gender, and education level.
    Results: Knowledge on symptoms of COVID-19 was generally high. Female respondents were more likely to identify more symptoms correctly compared to men (p < 0.001). However, youth reported very low levels of anyone being at risk of infection (7.1%). Most youth have adopted behavior necessary to slow down the infection. There were generally very low reported levels of inability to access health services related to sexual and reproductive health. About 50.0% of respondents reported significant decline in income during the pandemic period, nearly a third reported living in fear while 26.5% reported feeling stressed.
    Conclusion: There was high knowledge of COVID-19 symptoms, preventive strategies, and high adoption of preventive practices. Strategies to sustain behaviors positively adopted among young people will be critical to reduce the spread of COVID-19. Despite the low reported rates of inability to access sexual and reproductive health, response measures should include strategies that facilitate continuity of services among young people. The reported social effects of the pandemic show the need for interventions to meet the health and socio-economic needs of the youth and minimize the long-term consequences of the pandemic.
    MeSH term(s) Adolescent ; COVID-19 ; Cross-Sectional Studies ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Kenya/epidemiology ; Male ; SARS-CoV-2
    Language English
    Publishing date 2021-05-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1471-2458
    ISSN (online) 1471-2458
    DOI 10.1186/s12889-021-11067-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Synopsis of symptoms of COVID-19 during second wave of the pandemic in India.

    Kamble, Prafull / Daulatabad, Vandana / John, Nitin / John, Jyoti

    Hormone molecular biology and clinical investigation

    2021  Volume 43, Issue 1, Page(s) 97–104

    Abstract: ... 19's influence on cognitive function is one of COVID-19's long-term effects. More clinical situations ... symptoms such as anorexia, nausea, vomiting, or diarrhoea had a higher risk of negative outcomes. COVID ... COVID-19 was caused by the original coronavirus, severe acute respiratory syndrome associated ...

    Abstract COVID-19 was caused by the original coronavirus, severe acute respiratory syndrome associated coronavirus-2 (SARS CoV2), which originated in Wuhan, China. COVID-19 had a large breakout of cases in early 2020, resulting in an epidemic that turned into a pandemic. This quickly enveloped the global healthcare system. The principal testing method for COVID-19 detection, according to the WHO, is reverse transcription polymerase chain reaction (RT-PCR). Isolation of patients, quarantine, masking, social distancing, sanitizer use, and complete lockdown were all vital health-care procedures for everyone. With the 'new normal' and vaccination programmes, the number of cases and recovered patients began to rise months later. The easing of restrictions during the plateau phase resulted in a rebound of instances, which hit the people with more ferocity and vengeance towards the start of April 2021. Coronaviruses have evolved to cause respiratory, enteric, hepatic, and neurologic diseases, resulting in a wide range of diseases and symptoms such as fever, cough, myalgia or fatigue, shortness of breath, muscle ache, headache, sore throat, rhinorrhea, hemoptysis, chest pain, nausea, vomiting, diarrhoea, anosmia, and ageusia. Coronavirus infections can be mild, moderate, or severe in intensity. COVID-19 pulmonary dysfunction includes lung edoema, ground-glass opacities, surfactant depletion, and alveolar collapse. Patients who presented with gastrointestinal (GI) symptoms such as anorexia, nausea, vomiting, or diarrhoea had a higher risk of negative outcomes. COVID-19's influence on cognitive function is one of COVID-19's long-term effects. More clinical situations need to be reviewed by healthcare professionals so that an appropriate management protocol may be developed to reduce morbidity and death in future coming third/fourth wave cases.
    MeSH term(s) COVID-19/epidemiology ; Communicable Disease Control ; Gastrointestinal Diseases ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-12-07
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2536635-X
    ISSN 1868-1891 ; 1868-1883
    ISSN (online) 1868-1891
    ISSN 1868-1883
    DOI 10.1515/hmbci-2021-0043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Patterns and descriptors of COVID-19 testing and lab-confirmed COVID-19 incidence in Manitoba, Canada, March 2020-May 2021: A population-based study.

    Righolt, Christiaan H / Zhang, Geng / Sever, Emrah / Wilkinson, Krista / Mahmud, Salaheddin M

    Lancet Regional Health. Americas

    2021  Volume 2, Page(s) 100038

    Abstract: Background: We studied lab-confirmed COVID-19 infection (LCCI) testing, incidence, and severity ... the highest risk of LCCI, 1.3-6x the hazard of those in the highest income quintile. Long-term care (LTC ... testing rate during the second/third wave was 570/1,000 person-years, with an LCCI rate of 50/1,000 person ...

    Abstract Background: We studied lab-confirmed COVID-19 infection (LCCI) testing, incidence, and severity.
    Methods: We included all Manitoba residents and limited our severity analysis to LCCI patients. We calculated testing, incidence and vaccination rates between March 8, 2020 and June 1, 2021. We estimated the association between patient characteristics and testing (rate ratio [RR]; Poisson regression), including the reason for testing (screening, symptomatic, contact/outbreak asymptomatic), incidence (hazard ratio [HR]; Cox regression), and severity (prevalence ratio [PR], Cox regression).
    Findings: The overall testing rate during the second/third wave was 570/1,000 person-years, with an LCCI rate of 50/1,000 person-years. The secondary attack rate during the second/third wave was 16%. Across regions, young children (<10) had the lowest positivity for symptomatic testing, the highest positivity for asymptomatic testing, and the highest risk of LCCI as asymptomatic contact. People in the lowest income quintile had the highest risk of LCCI, 1.3-6x the hazard of those in the highest income quintile. Long-term care (LTC) residents were particularly affected in the second wave with HRs>10 for asymptomatic residents.
    Interpretation: Although the severity of LCCI in children was low, they have a high risk of asymptomatic positivity. The groups most vulnerable to LCCI, who should remain a focus of public health, were residents of Manitoba's North, LTC facilities, and low-income neighbourhoods.
    Funding: Canada Research Chair Program.
    Language English
    Publishing date 2021-08-13
    Publishing country England
    Document type Journal Article
    ISSN 2667-193X
    ISSN (online) 2667-193X
    DOI 10.1016/j.lana.2021.100038
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Post-COVID-19 condition is not only a question of persistent symptoms: structured screening including health-related quality of life reveals two separate clusters of post-COVID.

    Giszas, Benjamin / Trommer, Sabine / Schüßler, Nane / Rodewald, Andrea / Besteher, Bianca / Bleidorn, Jutta / Dickmann, Petra / Finke, Kathrin / Katzer, Katrin / Lehmann-Pohl, Katja / Lemhöfer, Christina / Pletz, Mathias W / Puta, Christian / Quickert, Stefanie / Walter, Martin / Stallmach, Andreas / Reuken, Philipp Alexander

    Infection

    2022  Volume 51, Issue 2, Page(s) 365–377

    Abstract: Purpose: Some patients experience long-term sequelae after infection ... in the analysis. Of those, 643 (70.7%) complained of having experienced persistent symptoms at the time ... of the survey. Cluster analysis based on QoL revealed two subgroups of people with persistent post-COVID ...

    Abstract Purpose: Some patients experience long-term sequelae after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, despite a present post-COVID condition, defined as "any symptom lasting longer than 12 weeks," only a subset of patients search for medical help and therapy.
    Method: We invited all adults with a positive real-time polymerase chain reaction (RT-PCR) for SARS-CoV-2 between March 2020 and September 2021 (n = 4091) in the city of Jena to answer a standardized questionnaire including demographic information, the course of the acute infection and current health status. K-means-clustering of quality of life (QoL) was used to explore post-COVID subgroups.
    Results: A total of 909 participants at a median interval of 367 (IQR 291/403) days after acute infection were included in the analysis. Of those, 643 (70.7%) complained of having experienced persistent symptoms at the time of the survey. Cluster analysis based on QoL revealed two subgroups of people with persistent post-COVID symptoms. Whereas 189/643 participants (29.4%) showed markedly diminished QoL, normal QoL was detected in 454/643 individuals (70.6%).
    Conclusion: Despite persistent symptoms being reported by nearly three quarters of participants, only one-third of these described a significant reduction in QoL (cluster 1), whereas the other two-thirds reported a near-normal QoL (cluster 2), thus indicating a differentiation between "post-COVID disease" and "post-COVID condition". The prevalence of clinically relevant post-COVID disease was at least 20.7%. Health policies should focus on this subset.
    MeSH term(s) Adult ; Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; Quality of Life ; Post-Acute COVID-19 Syndrome ; Real-Time Polymerase Chain Reaction
    Language English
    Publishing date 2022-07-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-022-01886-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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