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Article ; Online: COVID-19 Pneumonia in Patients With HIV: A Case Series.

Okoh, Alexis K / Bishburg, Eliahu / Grinberg, Sagy / Nagarakanti, Sandhya

Journal of acquired immune deficiency syndromes (1999)

2020 Volume 85, Issue 1, Page(s) e4–e5

MeSH term(s)	Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/pathology ; Female ; HIV Infections/complications ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/pathology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000002411
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Article: COVID-19 Pneumonia in Patients With HIV: A Case Series

Okoh, Alexis K / Bishburg, Eliahu / Grinberg, Sagy / Nagarakanti, Sandhya

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #486815
Database	COVID19

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Article ; Online: COVID-19 in patients with HIV: clinical case series.

Blanco, Jose L / Ambrosioni, Juan / Garcia, Felipe / Martínez, Esteban / Soriano, Alex / Mallolas, Josep / Miro, Jose M

The lancet. HIV

2020 Volume 7, Issue 5, Page(s) e314–e316

MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Antiretroviral Therapy, Highly Active ; Antiviral Agents/therapeutic use ; Betacoronavirus ; Bisexuality ; COVID-19 ; Coronavirus ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; Homosexuality, Male ; Humans ; Length of Stay ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Respiratory Tract Infections/etiology ; SARS-CoV-2 ; Sex Workers ; Sexual and Gender Minorities ; Treatment Outcome
Chemical Substances	Anti-Bacterial Agents ; Antiviral Agents
Keywords	covid19
Language	English
Publishing date	2020-04-15
Publishing country	Netherlands
Document type	Letter
ISSN	2352-3018
ISSN (online)	2352-3018
DOI	10.1016/S2352-3018(20)30111-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 Pneumonia in Patients With HIV

Okoh, Alexis K. / Bishburg, Eliahu / Grinberg, Sagy / Nagarakanti, Sandhya

JAIDS Journal of Acquired Immune Deficiency Syndromes

A Case Series

2020 Volume 85, Issue 1, Page(s) e4–e5

Keywords	Pharmacology (medical) ; Infectious Diseases ; covid19
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publishing country	us
Document type	Article ; Online
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/qai.0000000000002411
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hospitalized Patients With COVID-19 and Human Immunodeficiency Virus: A Case Series.

Childs, Kate / Post, Frank A / Norcross, Claire / Ottaway, Zoë / Hamlyn, Elizabeth / Quinn, Killian / Juniper, Thomas / Taylor, Chris

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2020 Volume 71, Issue 8, Page(s) 2021–2022

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; HIV ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-23
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciaa657
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Article ; Online: The COVID-19 pandemic and disruptions to essential health services in Kenya: a retrospective time-series analysis.

Kiarie, Helen / Temmerman, Marleen / Nyamai, Mutono / Liku, Nzisa / Thuo, Wangari / Oramisi, Violet / Nyaga, Lilly / Karimi, Janette / Wamalwa, Phidelis / Gatheca, Gladwell / Mwenda, Valerian / Ombajo, Loice Achieng / Thumbi, S M

The Lancet. Global health

2022 Volume 10, Issue 9, Page(s) e1257–e1267

Abstract: ... 9%), number of HIV tests conducted (45·3%; 23·9-63·0%), patients tested for malaria (31·9%; 16·7-46 ... health-care services, exacerbating health crises. We aimed to assess the effect of the COVID-19 pandemic ... 2021), and the period during the COVID-19-associated health-care workers' strike (from December, 2020 ...

Abstract	Background: Public health emergencies can disrupt the provision of and access to essential health-care services, exacerbating health crises. We aimed to assess the effect of the COVID-19 pandemic on essential health-care services in Kenya. Methods: Using county-level data routinely collected from the health information system from health facilities across the country, we used a robust mixed-effect model to examine changes in 17 indicators of essential health services across four periods: the pre-pandemic period (from January, 2018 to February, 2020), two pandemic periods (from March to November 2020, and February to October, 2021), and the period during the COVID-19-associated health-care workers' strike (from December, 2020 to January, 2021). Findings: In the pre-pandemic period, we observed a positive trend for multiple indicators. The onset of the pandemic was associated with statistically significant decreases in multiple indicators, including outpatient visits (28·7%; 95% CI 16·0-43·5%), cervical cancer screening (49·8%; 20·6-57·9%), number of HIV tests conducted (45·3%; 23·9-63·0%), patients tested for malaria (31·9%; 16·7-46·7%), number of notified tuberculosis cases (26·6%; 14·7-45·1%), hypertension cases (10·4%; 6·0-39·4%), vitamin A supplements (8·7%; 7·9-10·5%), and three doses of the diphtheria, tetanus toxoid, and pertussis vaccine administered (0·9%; 0·5-1·3%). Pneumonia cases reduced by 50·6% (31·3-67·3%), diarrhoea by 39·7% (24·8-62·7%), and children attending welfare clinics by 39·6% (23·5-47·1%). Cases of sexual violence increased by 8·0% (4·3-25·0%). Skilled deliveries, antenatal care, people with HIV infection newly started on antiretroviral therapy, confirmed cases of malaria, and diabetes cases detected were not significantly affected negatively. Although most of the health indicators began to recover during the pandemic, the health-care workers' strike resulted in nearly all indicators falling to numbers lower than those observed at the onset or during the pre-strike pandemic period. Interpretation: The COVID-19 pandemic and the associated health-care workers' strike in Kenya have been associated with a substantial disruption of essential health services, with the use of outpatient visits, screening and diagnostic services, and child immunisation adversely affected. Efforts to maintain the provision of these essential health services during a health-care crisis should target the susceptible services to prevent the exacerbation of associated disease burdens during such health crises. Funding: Bill & Melinda Gates Foundation.
MeSH term(s)	COVID-19/epidemiology ; Child ; Early Detection of Cancer ; Female ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Humans ; Kenya/epidemiology ; Malaria/epidemiology ; Mass Screening ; Pandemics ; Pregnancy ; Retrospective Studies ; Uterine Cervical Neoplasms
Language	English
Publishing date	2022-08-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2723488-5
ISSN	2214-109X ; 2214-109X
ISSN (online)	2214-109X
ISSN	2214-109X
DOI	10.1016/S2214-109X(22)00285-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 in people living with HIV: A multicenter case-series study.

Cabello, Alfonso / Zamarro, Belén / Nistal, Sara / Victor, Virginia / Hernández, Jana / Prieto-Pérez, Laura / Carrillo, Irene / Álvarez, Beatriz / Fernández-Roblas, Ricardo / Hernández-Segurado, Marta / Becares, Javier / Benito, José Miguel / Rallón, Norma / Téllez, Raquel / Castaño, Ángel Luis / Herrero, Antonio / Górgolas, Miguel

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2020 Volume 102, Page(s) 310–315

Abstract: ... with confirmed or suspected COVID-19 were included and compared with COVID-19 patients without HIV infection ... Results: Sixty-three patients with HIV infection and confirmed or suspected COVID-19 were analyzed ... between HIV-related factors and the severity of COVID-19. The rate of COVID-19 in HIV-patients was 1.68 ...

Abstract	Objectives: Information on how COVID-19 affects people living with HIV (PLHIV) remains scarce. Methods: An observational study was conducted in four public hospitals in Madrid. All HIV patients with confirmed or suspected COVID-19 were included and compared with COVID-19 patients without HIV infection. Results: Sixty-three patients with HIV infection and confirmed or suspected COVID-19 were analyzed. The median age was 46 years (IQR: 37-56 years), and 88.9% were men. The median duration of HIV infection was 10.8 years (IQR: 6.5-16.8 years), and 96.8% were on antiretroviral therapy. 84.1% had previous comorbidities. The most common symptoms were fever (66.1%), cough (66.1%) and dyspnea (46.8%). Pneumonia was found in 47.5%, 28.6% of patients had severe disease, and 32.3% were admitted to hospital. The ICU admission rate and the mortality rate were both 3.17%. A significant association was observed between age, arterial hypertension, overweight, and diabetes mellitus and the severity of COVID-19. No association was observed between HIV-related factors and the severity of COVID-19. The rate of COVID-19 in HIV-patients was 1.68%. Similar hospitalization (31.74% vs 32.57%) and ICU admission (3.17% vs 2%) rates were observed with non-HIV infected patients. A lower mortality rate during hospitalization (10% vs 21.37%) and a lower global mortality rate (3.17% vs 6.96%) were also observed. Conclusions: Established poor prognostic factors for COVID-19 patients, such as age and comorbidities, remain the main determinants for PLHIV. Neither the HIV severity nor the type of ARV treatment seem to influence the outcome of COVID-19. Large prospective cohorts are needed in order to establish the differences between HIV-positive and HIV-negative patients.
MeSH term(s)	Adult ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/therapy ; Comorbidity ; Female ; HIV Infections/complications ; HIV Infections/epidemiology ; HIV Infections/mortality ; Hospitalization ; Humans ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Prospective Studies
Keywords	covid19
Language	English
Publishing date	2020-10-27
Publishing country	Canada
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2020.10.060
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Article ; Online: Descriptive Analysis of Patients Living With HIV Affected by COVID-19.

Gudipati, Smitha / Brar, Indira / Murray, Shannon / McKinnon, John E / Yared, Nicholas / Markowitz, Norman

Journal of acquired immune deficiency syndromes (1999)

2020 Volume 85, Issue 2, Page(s) 123–126

Abstract: ... known if patients living with HIV (PLWH) are at a higher risk of severe COVID-19 or ... 2020, and April 30, 2020.: Results: Fourteen PLWH were diagnosed with COVID-19. Twelve patients were ... that HIV-positive patients with SARS-CoV-2 infection are not at a greater risk of severe disease or death ...

Abstract	Background: COVID-19 disease has spread globally and was declared a pandemic on March 11, 2020, by the World Health Organization. On March 10, the State of Michigan confirmed its first 2 cases of COVID-19, and the number of confirmed cases has reached 47,182 as of May 11, 2020, with 4555 deaths. Setting: Currently, little is known if patients living with HIV (PLWH) are at a higher risk of severe COVID-19 or if their antiretrovirals are protective. This study presents epidemiologic and clinical features of COVID-19 infected PLWH in Detroit, Michigan. Methods: This is a case series that included 14 PLWH with laboratory-confirmed COVID-19 infection who were evaluated at Henry Ford Hospital in Detroit, Michigan, between March 20, 2020, and April 30, 2020. Results: Fourteen PLWH were diagnosed with COVID-19. Twelve patients were men and 2 were women; 13 patients were virally suppressed. Eight patients were hospitalized, and 6 patients were told to self-quarantine at home after their diagnoses. Three patients who were admitted expired during their hospital stay. No patient required bilevel positive airway pressure or nebulizer use in the emergency department, and none developed acute respiratory distress syndrome, pulmonary embolism, deep venous thrombosis, or a cytokine storm while on therapy for COVID-19. Conclusion: Although the clinical spectrum of COVID-19 among PLWH cannot be fully ascertained by this report, it adds to the data that suggest that HIV-positive patients with SARS-CoV-2 infection are not at a greater risk of severe disease or death as compared to HIV-negative patients.
MeSH term(s)	African Americans ; COVID-19 ; Comorbidity ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/ethnology ; Female ; HIV Infections/complications ; HIV Infections/epidemiology ; HIV Infections/ethnology ; Hispanic Americans ; Humans ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/ethnology
Keywords	covid19
Language	English
Publishing date	2020-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	645053-2
ISSN	1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
ISSN (online)	1944-7884 ; 1077-9450
ISSN	0897-5965 ; 0894-9255 ; 1525-4135
DOI	10.1097/QAI.0000000000002450
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Article ; Online: AKI and Collapsing Glomerulopathy Associated with COVID-19 and

Wu, Huijuan / Larsen, Christopher P / Hernandez-Arroyo, Cesar F / Mohamed, Muner M B / Caza, Tiffany / Sharshir, Moh'd / Chughtai, Asim / Xie, Liping / Gimenez, Juan M / Sandow, Tyler A / Lusco, Mark A / Yang, Haichun / Acheampong, Ellen / Rosales, Ivy A / Colvin, Robert B / Fogo, Agnes B / Velez, Juan Carlos Q

Journal of the American Society of Nephrology : JASN

2020 Volume 31, Issue 8, Page(s) 1688–1695

Abstract: ... molecular features in six Black patients with COVID-19 presenting with AKI and : Results: This case ... series included six Black patients with COVID-19 (four men, two women), mean age 55 years. At biopsy day ... Background: Kidney involvement is a feature of COVID-19 and it can be severe in Black patients ...

Abstract	Background: Kidney involvement is a feature of COVID-19 and it can be severe in Black patients. Previous research linked increased susceptibility to collapsing glomerulopathy, including in patients with HIV-associated nephropathy, to apo L1 ( Methods: To investigate genetic, histopathologic, and molecular features in six Black patients with COVID-19 presenting with AKI and Results: This case series included six Black patients with COVID-19 (four men, two women), mean age 55 years. At biopsy day, mean serum creatinine was 6.5 mg/dl and mean urine protein-creatinine ratio was 11.5 g. Kidney biopsy specimens showed collapsing glomerulopathy, extensive foot process effacement, and focal/diffuse acute tubular injury. Three patients had endothelial reticular aggregates. We found no evidence of viral particles or SARS-CoV-2 RNA. NanoString showed elevated chemokine gene expression and changes in expression of genes associated with acute tubular injury compared with controls. All six patients had an Conclusions: Collapsing glomerulopathy in Black patients with COVID-19 was associated with high-risk
MeSH term(s)	Acute Kidney Injury/complications ; Acute Kidney Injury/genetics ; Adult ; Aged ; Alleles ; Apolipoprotein L1/genetics ; Biopsy ; Black People ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/genetics ; Creatinine/blood ; Female ; Genotype ; Humans ; Kidney/pathology ; Kidney Glomerulus/physiopathology ; Kidney Glomerulus/virology ; Kidney Tubules/pathology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/genetics ; Risk
Chemical Substances	APOL1 protein, human ; Apolipoprotein L1 ; Creatinine (AYI8EX34EU)
Keywords	covid19
Language	English
Publishing date	2020-06-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1085942-1
ISSN	1533-3450 ; 1046-6673
ISSN (online)	1533-3450
ISSN	1046-6673
DOI	10.1681/ASN.2020050558
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Article ; Online: Post-mortem examination of Hospital Inpatient COVID-19 Deaths in Lusaka, Zambia - A Descriptive Whole-body Autopsy Series.

Himwaze, Cordilia Maria / Telendiy, Viktor / Maate, Fred / Mupeta, Songwe / Chitalu, Chanda / Chanda, Duncan / Julius, Peter / Mumba, Chibamba / Marimo, Clemence / Hamukale, Amos / Mulenga, Llyod / Shibemba, Aaron Lunda / Zumla, Alimuddin / Mucheleng'anga, Luchenga Adam

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2021 Volume 108, Page(s) 363–369

Abstract: ... and COVID-19 pneumonia (7/29, 25%). 22/29 (76%) had co-morbidities. Common co-morbidities included HIV ... Zambia - the first large autopsy case series from Africa.: Methods: We performed a descriptive ... Background: Since information on the pathology of COVID-19 from sub-Saharan Africa (SSA) remains ...

Abstract	Background: Since information on the pathology of COVID-19 from sub-Saharan Africa (SSA) remains scarce, the objective of our study was to define the gross pathology and histological features of COVID-19. We report data from 29 whole-body autopsies of COVID-19 deaths occurring in hospitals in Lusaka, Zambia - the first large autopsy case series from Africa. Methods: We performed a descriptive post-mortem examination study of inpatient COVID-19 related deaths at two hospitals in Lusaka, Zambia. Whole-body autopsies were conducted according to Standard Operating Procedures. Gross and histopathological examinations of all organs were performed. Patient demographics, history, co-morbidities, autopsy gross and microscopic findings, and cause(s) of death were recorded and analyzed using STATA version 14. Variables were grouped and presented as frequencies and percentages. Findings: Autopsies were performed on 29 decedents (mean age = 44 ± 15.8years; age range = 19-82; 17/29 [58.8%] males). 22/29 [75.9%] cases were <55 years of age. A spectrum of pathological manifestations of COVID-19 were seen in all organs. The commonest causes of death were pulmonary thromboembolism (13/29, 45%), Diffuse Alveolar Damage (9/29, 31%), and COVID-19 pneumonia (7/29, 25%). 22/29 (76%) had co-morbidities. Common co-morbidities included HIV (8/29, 28%), Hypertension (6/29, 20%) Tuberculosis (3/29, 10%), Diabetes (3/29, 10%). Conclusions: A spectrum of gross anatomical and histopathological findings are seen in COVID-19 deaths in hospitalized decedents. These appear broadly similar to those reported from China, Europe and USA. Differences include a younger age group, and co-morbidities of HIV and TB co-infection which require further investigation.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Autopsy ; COVID-19 ; Hospitals ; Humans ; Inpatients ; Lung ; Male ; Middle Aged ; SARS-CoV-2 ; Young Adult ; Zambia/epidemiology
Language	English
Publishing date	2021-06-17
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2021.06.013
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