Article: Impact of Chronic RAAS Use in Elderly COVID-19 Patients: A Retrospective Analysis.
2021 Volume 10, Issue 14
Abstract: ... that these medications might increase the risk of mortality by COVID-19. This is a retrospective cohort of 346 patients ... 113, 32.7%). Ninety-eight patients (28.3%) had chronic kidney disease and almost half of the patients ... old. Most patients had arterial hypertension (n = 279, 80.6%), almost half (n = 161, 46.5%) had ...
| Abstract | Corona Virus Disease-19 (COVID-19) recently emerged as a global pandemic. Advanced age is the most important risk factor for increased virus susceptibility and worse outcomes. Many older adults are currently treated with renin-angiotensin-aldosterone system (RAAS) inhibitors and there is concern that these medications might increase the risk of mortality by COVID-19. This is a retrospective cohort of 346 patients older than 65 years with COVID-19, at the Department of Medicine of the Centro Hospitalar Universitário Lisboa Norte, in Portugal, hospitalized between March 2020 and August 2020. Mean age was 80.9 ± 8.7 years old. Most patients had arterial hypertension (n = 279, 80.6%), almost half (n = 161, 46.5%) had cardiovascular disease and approximately one-third of patients had heart failure (n = 127, 36.7%) or diabetes Mellitus (n = 113, 32.7%). Ninety-eight patients (28.3%) had chronic kidney disease and almost half of the patients (49.4%) were chronically under renin-angiotensin-aldosterone system (RAAS) inhibitors. Twenty percent of patients died during hospitalization. In a multivariate analysis, older age (OR 1.11, 95% CI 1.04, 1.18, |
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| Language | English |
| Publishing date | 2021-07-16 |
| Publishing country | Switzerland |
| Document type | Journal Article |
| ZDB-ID | 2662592-1 |
| ISSN | 2077-0383 |
| ISSN | 2077-0383 |
| DOI | 10.3390/jcm10143147 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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