Article ; Online: Endothelial function provides early prognostic information in patients with COVID-19: A cohort study.
2021 Volume 185, Page(s) 106469
Abstract: ... of hospitalization.: Conclusion: Patients hospitalized for COVID-19 present endothelial vascular dysfunction early ... to patients without COVID-19.: Methods: A prospective observational study involving 180 patients ... to COVID-19 have yet to be determined.: Objective: To assess endothelial function characteristics ...
| Abstract | Background: The prothrombotic phenotype and diffuse intravascular coagulation observed in COVID-19 reflect endothelial dysfunction, which is linked to blood flow delivery deficiencies and cardiovascular risk. Assessments of detect vascular deficiencies among newly diagnosed and hospitalized patients due to COVID-19 have yet to be determined. Objective: To assess endothelial function characteristics in relation to length of hospitalization and mortality in patients diagnosed with COVID-19 and compare to patients without COVID-19. Methods: A prospective observational study involving 180 patients with confirmed COVID-19 (COVID-19 group) or suspected and ruled out COVID-19 (Non-COVID-19 group). Clinical evaluation and flow mediated vasodilation (FMD) were performed between the first 24-48 h of hospitalization. Patients were followed until death or discharge. Results: We evaluated 98 patients (COVID-19 group) and 82 (Non-COVID-19 group), COVID-19 group remained hospitalized longer and more deaths occurred compared to the Non-COVID-19 group (p = 0.01; and p < 0.01). Patients in COVID-19 group also had a significantly greater reduction in both FMDmm and FMD% (p < 0.01 in both). We found that absolute FMD≤0.26 mm and relative FMD≤3.43% were the ideal cutoff point to predict mortality and longer hospital stay. In Kaplan Meyer's analysis patients had a high probability of death within a period of up to 10 days of hospitalization. Conclusion: Patients hospitalized for COVID-19 present endothelial vascular dysfunction early, remained hospitalized longer and had a higher number of deaths, when compared with patients without COVID-19. |
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| MeSH term(s) | Brachial Artery/physiopathology ; COVID-19/epidemiology ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/physiopathology ; Comorbidity ; Endothelium, Vascular/physiopathology ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prospective Studies ; Regional Blood Flow/physiology ; SARS-CoV-2 ; United States/epidemiology ; Vasodilation/physiology | |||||
| Language | English | |||||
| Publishing date | 2021-05-23 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 1003348-8 | |||||
| ISSN | 1532-3064 ; 0954-6111 | |||||
| ISSN (online) | 1532-3064 | |||||
| ISSN | 0954-6111 | |||||
| DOI | 10.1016/j.rmed.2021.106469 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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